Protein Information

Name monoamine oxidase
Synonyms Adrenalin oxidase; Amine oxidase; Amine oxidase [flavin containing] B; MAO B; MAOB; Monoamine oxidase; Monoamine oxidase B; Monoamine oxidase type B…

Compound Information

Name chlordimeform
CAS

Reference List

PubMed Abstract RScore(About this table)
7235738 Kaloyanova F, Bainova A, Zaprianov Z: Inhibition of monoamine oxidase activity after combined action of chlordimeform with the antidepressant nialamide. Arch Environ Contam Toxicol. 1981;10(1):1-8.
112(1,2,2,2) Details
4058679 Boyes WK, Moser VC, MacPhail RC, Dyer RS: Monoamine oxidase inhibition cannot account for changes in visual evoked potentials produced by chlordimeform. Neuropharmacology. 1985 Sep;24(9):853-60.
112(1,2,2,2) Details
4701207 Aziz SA, Knowles CO: Inhibition of monoamine oxidase by the pesticide chlordimeform and related compounds. Nature. 1973 Apr 6;242(5397):417-8.
81(1,1,1,1) Details
428001 Hollingworth RM, Leister J, Ghali G: Mode of action of formamidine pesticides: an evaluation of monoamine oxidase as the target. Chem Biol Interact. 1979 Jan;24(1):35-49.

The ability of formamidine pesticide, chlordimeform (N'-(4-chloro-o-toyl)-N,N-dimethylformamidine) (CDM), and several of its major metabolites to inhibit monoamine oxidase (MAO) in mouse tissues in vitro and in vivo was examined, and related to the hypothesis that inhibition of MAO is responsible for the lethal effects of CDM.
81(1,1,1,1) Details
144803 Robinson CP, Smith PW: Lack of involvement of monoamine oxidase inhibition in the lethality of acute poisoning by chlordimeform. J Toxicol Environ Health. 1977 Oct;3(3):565-8.
81(1,1,1,1) Details
632437 Maitre L, Felner A, Waldmeier P, Kehr W: Monoamine oxidase inhibition in brain and liver of rats treated with chlordimeform. J Agric Food Chem. 1978 Mar-Apr;26(2):442-6.
81(1,1,1,1) Details
976227 Matsumura F, Beeman RW: Biochemical and physiological effects of chlordimeform. . Environ Health Perspect. 1976 Apr;14:71-82.

Specifically, chlordimeform causes a build-up of the amines 5-hydroxytryptamine and to a lesser extent norepinephrine in the rat brain in vivo, antagonizes the in vivo action of reserpine in the rat (reserpine depletes amine stores in the CNS), inhibits monoamine oxidase from rat liver in vitro, and causes hypotension in rabbits.
31(0,1,1,1) Details
406057 Gripois D, Moreteau B, Ramade F: [Monoamine oxidase activity of the brain of Locusta migratoria in normal conditions and after intoxication by two insecticides: chlordimeform and dieldrin]. C R Acad Sci Hebd Seances Acad Sci D. 1977 Mar 21;284(12):1079-82.
6(0,0,1,1) Details
7773544 Alemany R, Olmos G, Garcia-Sevilla JA: The effects of phenelzine and other monoamine oxidase inhibitor antidepressants on brain and liver I2 imidazoline-preferring receptors. Br J Pharmacol. 1995 Feb;114(4):837-45.

In contrast, chronic treatment (7 days) with the reversible MAO-A inhibitors, moclobemide (1 and 10 mg kg-1, i.p.) or chlordimeform (10 mg kg-1, i.p.) or with the reversible MAO-B inhibitor Ro 16-6491 (1 and 10 mg kg-1, i.p.) did not alter the density of I2 imidazoline-preferring receptors in the rat brain and liver; except for the higher dose of Ro 16-6491 which only decreased the density of these putative receptors in the liver (38%). 3.
2(0,0,0,2) Details
836412 Neumann R, Voss G: MAO inhibition, an unlikely mode of action for chlordimeform. . Experientia. 1977 Jan 15;33(1):23-4.

Inhibition constants of several formamidines, their corresponding formanilides and other representatives of compounds derived from aniline, such as phenylureas, N-phenyl-carbamates and acylanilides, were determined for rat liver monoamine oxidase.
1(0,0,0,1) Details
6251379 Evans PD, Gee JD: Action of formamidine pesticides on octopamine receptors. . Nature. 1980 Sep 4;287(5777):60-2.


We report here that the formamidine acaricide/insecticide, chlordimeform (CDM), and its demethylated deivative can mimic the actions of octopamine at the locust neuromuscular junctions.
0(0,0,0,0) Details