| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | dimethoate |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16833148 | Long SM, Dawson A, Shore RF: A comparison of the effects of single and repeated exposure to an organophosphate insecticide on acetylcholinesterase activity in mammals. Environ Toxicol Chem. 2006 Jul;25(7):1857-63. Cytochrome P450 enzyme activity (CYP2B) was inhibited in the dimethoate-dosed mice. |
87(1,1,2,2) | Details |
| 18384757 | Eyer P, Radtke M, Worek F: Reactions of isodimethoate with human red cell acetylcholinesterase. . Biochem Pharmacol. 2008 May 15;75(10):2045-53. Epub 2008 Feb 26. Isodimethoate shows an inhibition rate constant towards human red blood cell acetylcholinesterase (AChE) of 2.3x10 (3) M (-1) min (-1) (pH 7.4, 37 degrees C), indicating a somewhat higher potency than found with omethoate, the CYP450-mediated active metabolite of pure dimethoate. |
81(1,1,1,1) | Details |
| 16112789 | Sharma Y, Bashir S, Irshad M, Nag TC, Dogra TD: Dimethoate-induced effects on antioxidant status of liver and brain of rats following subchronic exposure. Toxicology. 2005 Nov 15;215(3):173-81. Epub 2005 Aug 19. This study concludes that oxidative stress due to dimethoate may be ascribed to induction of Cytochrome P450, inhibition of AChE and disturbance in activities of GSH and GST enzymes causing lipid peroxidation and histological and electron microscopic changes in liver and brain. |
32(0,1,1,2) | Details |
| 1816087 | Siddiqui MK, Anjum F, Mehboob M, Mustafa M: Effect of dimethoate on hepatic cytochrome P-450 and glutathione S-transferase activity in pigeon and rat. Indian J Exp Biol. 1991 Nov;29(11):1071-3. |
12(0,0,2,2) | Details |
| 7481747 | Johnston G: The study of interactive effects of pollutants: a biomarker approach. Sci Total Environ. 1995 Oct 27;171(1-3):205-12. The mechanism of increased activation of malathion due to induction of cytochrome P-450 by prochloraz is reviewed. Birds pretreated with prochloraz showed a trend towards greater inhibition of serum BuChE activity at most time points following dosing with the OPs dimethoate and chlorpyriphos. |
1(0,0,0,1) | Details |
| 10964798 | Walsh LP, McCormick C, Martin C, Stocco DM: Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression. Environ Health Perspect. 2000 Aug;108(8):769-76. We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein. StAR protein mediates the rate-limiting and acutely regulated step in steroidogenesis, the transfer of from the outer to the inner mitochondrial membrane where the cytochrome P450 side chain cleavage (P450scc) enzyme initiates the synthesis of all steroid hormones. |
1(0,0,0,1) | Details |
| 15590108 | Sharma Y, Bashir S, Irshad M, Gupta SD, Dogra TD: Effects of acute dimethoate administration on antioxidant status of liver and brain of experimental rats. Toxicology. 2005 Jan 5;206(1):49-57. The results indicated an increase in hepatic cytochrome P450, lipid peroxidation, catalase, superoxide dismutase, peroxidase, glutathione reductase in liver and brain at 90 and 75 mg/kg doses. |
1(0,0,0,1) | Details |