| Name | cyclin A |
|---|---|
| Synonyms | CCN 1; CCN1; CCNA; CCNA 2; CCNA2; Cyclin A; Cyclin A2; Cyclin As… |
| Name | kinetin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9552377 | Meijer L: Chemical inhibitors of cyclin-dependent kinases. . Prog Cell Cycle Res. 1995;1:351-63. The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk's), constituted of at least two subunits, a catalytic subunit (cdk1-7) associated with a regulatory subunit (cyclin A-H). |
1(0,0,0,1) | Details |
| 9705226 | Moreau JL, Marques F, Barakat A, Schatt P, Lozano JC, Peaucellier G, Picard A, Geneviere AM: Cdk2 activity is dispensable for the onset of DNA replication during the first mitotic cycles of the sea urchin early embryo. Dev Biol. 1998 Aug 15;200(2):182-97. We show that Cdk2 as well as its potential partner cyclin A are present in the nucleus in G1 and S phase and therefore available for DNA replication. |
1(0,0,0,1) | Details |
| 10542199 | Choi KS, Eom YW, Kang Y, Ha MJ, Rhee H, Yoon JW, Kim SJ: Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. J Biol Chem. 1999 Nov 5;274(45):31775-83. TGF-beta1 induced a transient increase in the expression of Cdc2, cyclin A, cyclin B, and cyclin D1 at an early phase of apoptosis. |
1(0,0,0,1) | Details |
| 10602500 | David-Pfeuty T: Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells. Oncogene. 1999 Dec 9;18(52):7409-22. At concentrations equal or superior to respectively 30- and 20-fold their in vitro IC50 values for cyclin B/Cdk1, cyclin A/Cdk2 and cyclin E/Cdk2, the Cdk inhibitors precipitately induce a dramatic nuclear accumulation of wt p53 and a delocalization of nucleolin from the nucleolus in all interphase cells, whatever their cell cycle status, acting in this way like the DNA-damaging drug, mitomycin C (7 microg/ml). |
1(0,0,0,1) | Details |
| 7549905 | Abraham RT, Acquarone M, Andersen A, Asensi A, Belle R, Berger F, Bergounioux C, Brunn G, Buquet-Fagot C, Fagot D, et al.: Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. . Biol Cell. 1995;83(2-3):105-20. Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. |
1(0,0,0,1) | Details |
| 10234573 | Zhang W, Lee JC, Kumar S, Gowen M: ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. J Bone Miner Res. 1999 Apr;14(4):528-35. Cyclin A was complexed with Cdk2 in unstimulated MG63 cells, but Cdk2 kinase activity in the complex was up-regulated only in IGF-1-treated cells. |
1(0,0,0,1) | Details |
| 10884382 | Jin YH, Yoo KJ, Lee YH, Lee SK: Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. J Biol Chem. 2000 Sep 29;275(39):30256-63. |
7(0,0,0,7) | Details |
| 11237594 | Haidweger E, Novy M, Rotheneder H: Modulation of Sp1 activity by a cyclin A/CDK complex. . J Mol Biol. 2001 Feb 16;306(2):201-12. |
6(0,0,0,6) | Details |
| 12387751 | Dietrich C, Faust D, Budt S, Moskwa M, Kunz A, Bock KW, Oesch F: 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent release from contact inhibition in WB-F344 cells: involvement of cyclin A. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):117-26. |
5(0,0,0,5) | Details |
| 16759516 | Tian DS, Wang W, Xu YL, Yu ZY, Xie MJ, Wang P, Zhang GB: [Effects of cyclin dependent protein kinase inhibitor olomoucine on the microenvironment of axonal regeneration after spinal cord injury: an experiment with rats]. Zhonghua Yi Xue Za Zhi. 2006 Apr 4;86(13):901-5. Western blotting was used to detect the expression of the cell cycle related proteins, cyclin A, cyclin B, cyclin E, and proliferating cell nuclear antigen (PCNA). |
2(0,0,0,2) | Details |