Protein Information

Name involucrin
Synonyms IVL; Involucrin; Involucrins

Compound Information

Name kinetin
CAS

Reference List

PubMed Abstract RScore(About this table)
16804007 Berge U, Kristensen P, Rattan SI: Kinetin-induced differentiation of normal human keratinocytes undergoing aging in vitro. Ann N Y Acad Sci. 2006 May;1067:332-6.

The combination of calcium and 40 microM kinetin led to a decrease by 23% in the K14 level, to an increase in the level of K10 by 55%, and to a two-fold rise in the involucrin level.
8(0,0,1,3) Details
18262743 Berge U, Kristensen P, Rattan SI: Hormetic modulation of differentiation of normal human epidermal keratinocytes undergoing replicative senescence in vitro. Exp Gerontol. 2008 Jul;43(7):658-62. Epub 2008 Jan 10.

Using this experimental model system, we have studied age-related changes in the ability of serially passaged NHEK to enter into differentiation in the presence of calcium, as measured by the levels of differentiation markers involucrin, p38 and Hsp27.
The results obtained in these studies show that calcium-induced differentiation of NHEK becomes progressively delayed during cellular aging in vitro, which can be modulated by treatments such as mild heat stress, kinetin and curcumin.
1(0,0,0,1) Details