| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | kinetin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18162289 | Choi BH, Kim W, Wang QC, Kim DC, Tan SN, Yong JW, Kim KT, Yoon HS: Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Lett. 2008 Mar 8;261(1):37-45. Epub 2007 Dec 26. |
7(0,0,1,2) | Details |
| 11313870 | Kim SG, Kim SN, Jong HS, Kim NK, Hong SH, Kim SJ, Bang YJ: Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells. Oncogene. 2001 Mar 8;20(10):1254-65. Of note, caspase-3 was activated in accordance with TGF-beta1-induced G1 arrest. |
4(0,0,0,4) | Details |
| 10884382 | Jin YH, Yoo KJ, Lee YH, Lee SK: Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. J Biol Chem. 2000 Sep 29;275(39):30256-63. |
3(0,0,0,3) | Details |
| 20139069 | Choi BH, Feng L, Yoon HS: FKBP38 protects Bcl-2 from caspase-dependent degradation. . J Biol Chem. 2010 Mar 26;285(13):9770-9. Epub 2010 Feb 5. In caspase-3-activated cells, the knockdown of endogenous FKBP38 by small interfering RNA resulted in Bcl-2 down-regulation as well, which was significantly recovered by the treatment with caspase inhibitors or overexpression of FKBP38. We showed that the overexpression of FKBP38 attenuates reduction rate of Bcl-2, thus resulting in an increment of the intracellular Bcl-2 level, contributing to the resistance of apoptotic cell death induced by the treatment of kinetin riboside, an anticancer drug. |
2(0,0,0,2) | Details |
| 16155345 | Yu X, Caltagarone J, Smith MA, Bowser R: DNA damage induces cdk2 protein levels and histone H2B phosphorylation in SH-SY5Y neuroblastoma cells. J Alzheimers Dis. 2005 Sep;8(1):7-21. Olomucine concurrently delayed histone H2B phosphorylation, caspase-3 activation and cell death. |
2(0,0,0,2) | Details |
| 15827328 | Jiang H, Zhang L, Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Hunter TJ, Corcoran GB, Seidman MD, Levine RA: -induced apoptotic death in human U251 glioma cells. Mol Cancer Ther. 2005 Apr;4(4):554-61. induces activation of caspase-3 and increases the cleavage of the downstream caspase substrate, poly (ADP- polymerase. |
1(0,0,0,1) | Details |
| 10871858 | Edamatsu H, Gau CL, Nemoto T, Guo L, Tamanoi F: Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene. 2000 Jun 22;19(27):3059-68. The released cytochrome c then induces events leading to the activation of caspase-3. |
1(0,0,0,1) | Details |
| 10851267 | Atienza C Jr, Elliott MJ, Dong YB, Yang HL, Stilwell A, Liu TJ, McMasters KM: Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors. Int J Mol Med. 2000 Jul;6(1):55-63. Caspase 3/CPP32 activation and PARP cleavage in response to E2F-1 overexpression, alone and in combination with roscovitine, implicate the caspase cascade in E2F-1-mediated apoptosis of gastric cancer cells. |
1(0,0,0,1) | Details |
| 15130771 | Monaco EA 3rd, Beaman-Hall CM, Mathur A, Vallano ML: Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. Biochem Pharmacol. 2004 May 15;67(10):1947-64. Based on several criteria, including delayed time course and establishment of an irreversible commitment point of death, pyknotic cell and nuclear morphology, and caspase-3 cleavage, the death process is apoptotic. |
1(0,0,0,1) | Details |
| 19081935 | Cheong J, Goh D, Yong JW, Tan SN, Ong ES: Inhibitory effect of kinetin riboside in human heptamoa, HepG2. Mol Biosyst. 2009 Jan;5(1):91-8. Epub 2008 Nov 25. |
0(0,0,0,0) | Details |