| Name | P27 |
|---|---|
| Synonyms | FAM14D; p27; IFI27; ISG12; ISG12(a) protein; Interferon alpha induced 11.5 kDa protein; Interferon alpha inducible protein 27; ISG12(a) proteins… |
| Name | kinetin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11438580 | Katchanov J, Harms C, Gertz K, Hauck L, Waeber C, Hirt L, Priller J, von Harsdorf R, Bruck W, Hortnagl H, Dirnagl U, Bhide PG, Endres M: Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death. J Neurosci. 2001 Jul 15;21(14):5045-53. Loss of p27 (Kip1), another Cdk inhibitor, precedes cell death in neocortical neurons subjected to - deprivation in vitro. |
1(0,0,0,1) | Details |
| 17006629 | Akashiba H, Matsuki N, Nishiyama N: p27 small interfering RNA induces cell death through elevating cell cycle activity in cultured cortical neurons: a proof-of-concept study. Cell Mol Life Sci. 2006 Oct;63(19-20):2397-404. |
4(0,0,0,4) | Details |
| 11313870 | Kim SG, Kim SN, Jong HS, Kim NK, Hong SH, Kim SJ, Bang YJ: Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells. Oncogene. 2001 Mar 8;20(10):1254-65. Activated caspase-3 is targeted to cleave p21 (cip1), p27 (kip1), and Rb, which play important roles in TGF-beta-induced G1 arrest, into inactive fragments. |
3(0,0,0,3) | Details |
| 10597222 | Baldassarre G, Barone MV, Belletti B, Sandomenico C, Bruni P, Spiezia S, Boccia A, Vento MT, Romano A, Pepe S, Fusco A, Viglietto G: Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation. Oncogene. 1999 Nov 4;18(46):6241-51. Conversely, constitutive expression of p27 into NT2/D1 cells induced a marked reduction in the growth potential of these cells and partially reproduced -induced modification of surface antigen expression (down-regulation of SSEA-3 expression and up-regulation of VINIS-53 expression). |
2(0,0,0,2) | Details |
| 12147712 | Mad'arova J, Lukesova M, Hlobilkova A, Strnad M, Vojtesek B, Lenobel R, Hajduch M, Murray PG, Perera S, Kolar Z: Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines. Mol Pathol. 2002 Aug;55(4):227-34. METHODS: The effects of olomoucine and bohemine were studied on the following parameters: (1) cell proliferation, by measurement of DNA content; (2) viability, by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium and/or XTT (2,3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide) test; and (3) the expression of p53, pRB, Bcl-2, Bax, p16, p21, p27, cyclins A, B, D1, E, p34 (cdc2), and the androgen receptor (AR), by western blot analysis. |
1(0,0,0,1) | Details |
| 10884382 | Jin YH, Yoo KJ, Lee YH, Lee SK: Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. J Biol Chem. 2000 Sep 29;275(39):30256-63. In contrast, another Cdk inhibitory protein, p27 (KIP1), which is associated with cyclin A-Cdk2 and cyclin E-Cdk2 complexes, remained unaltered during apoptosis. |
1(0,0,0,1) | Details |