Protein Information

Name cyclin B1
Synonyms CCNB; CCNB 1; CCNB1; Cyclin B1; G2/mitotic specific cyclin B1; Cyclin B1s; G2/mitotic specific cyclin B1s

Compound Information

Name kinetin
CAS

Reference List

PubMed Abstract RScore(About this table)
9514874 Nuckolls FJ, Khan AS, Butler R, Katula KS: Differential response of the human cyclin B1 promoter to inhibitors of the cell cycle in NIH3T3 cells. Biochem Biophys Res Commun. 1998 Mar 6;244(1):280-4.

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17925171 Du XP, Sun MZ, Yu ZY, Chen HX, Tian DS, Xie MJ, Wang W: [Effects of cyclin dependent protein kinase inhibitor olomoucine on the neuronal apoptosis after status epilepticus: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2007 Aug 7;87(29):2025-9.


Immunofluorescence (IF) staining was used to detect the expression of neuronal nuclear nucleoprotein (NeuN) and cyclin B1.
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10567774 Fan S, Duba DE, O'Connor PM: Cellular effects of olomoucine in human lymphoma cells differing in p53 function. Chemotherapy. 1999 Nov-Dec;45(6):437-45.


In this study we investigated the cellular effects of olomoucine in two human Burkitt's lymphoma cell lines, WMN (containing wild-type p53) and CA46 (containing mutant p53), and found that in consistency with its ability to block the activity of cyclin E/Cdk2 and cyclin B1/Cdc2 kinases, olomoucine caused cell cycle arrest at both G1/S and G2/S boundaries.
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19368812 Fei XF, Qin ZH, Xiang B, Li LY, Han F, Fukunaga K, Liang ZQ: Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine. Brain Res. 2009 Apr 6;1264:85-97. Epub 2009 Feb 6.


Using immunocytochemistry and real-time PCR we demonstrated that cyclin D1, cyclin B1 and proliferating cell nuclear antigen (PCNA) were aberrantly expressed in some dopaminergic neurons after 6-OHDA infusion.
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9268294 Trzepacz C, Lowy AM, Kordich JJ, Groden J: Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34. J Biol Chem. 1997 Aug 29;272(35):21681-4.


We also show that APC is a substrate for recombinant human p34 (cdc2)-cyclin B1.
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