| Name | cyclin D1 |
|---|---|
| Synonyms | B cell CLL/lymphoma 1; B cell leukemia 1; BCL 1; BCL 1 oncogene; BCL1; CCND 1; CCND1; Cyclin D1… |
| Name | kinetin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18431519 | Tiedemann RE, Mao X, Shi CX, Zhu YX, Palmer SE, Sebag M, Marler R, Chesi M, Fonseca R, Bergsagel PL, Schimmer AD, Stewart AK: Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity. J Clin Invest. 2008 May;118(5):1750-64. Kinetin riboside induced marked suppression of CCND2 transcription and rapidly suppressed cyclin D1 and D2 protein expression in primary myeloma cells and tumor lines, causing cell-cycle arrest, tumor cell-selective apoptosis, and inhibition of myeloma growth in xenografted mice. |
69(0,2,3,4) | Details |
| 17243097 | Zhu Z, Zhang Q, Yu Z, Zhang L, Tian D, Zhu S, Bu B, Xie M, Wang W: Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo. Glia. 2007 Apr 1;55(5):546-58. To demonstrate further that cell cycle regulation impacts on astrogliosis, cyclin D1 gene knockout mice (cyclin D1 (-/-)) were subjected to ischemia, and we found that the percentage of Ki67-positive astrocytes in these mice was markedly reduced in the boundary zone. |
2(0,0,0,2) | Details |
| 19138471 | Zhou Y, Guo YJ, Liu X, Mei YW: Cell cycle inhibitor enhances the resolution of HSV-1-induced proinflammatory response in murine microglial cells. Neurol Res. 2009 Nov;31(9):910-6. Epub 2009 Jan 9. The expression change of cyclin D1 and myeloid cell leukemia 1 (Mcl-1) in microglia were detected by Western blot analysis. |
2(0,0,0,2) | Details |
| 16530228 | Appert-Collin A, Hugel B, Levy R, Niederhoffer N, Coupin G, Lombard Y, Andre P, Poindron P, Gies JP: Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons. Life Sci. 2006 Jun 27;79(5):484-90. Epub 2006 Mar 10. Recent evidence suggests that apoptosis in post-mitotic neurons involves an aborted attempt of cells to re-enter the cell cycle which is characterized by increased expression of cyclins, such as cyclin D1, prior to death. |
2(0,0,0,2) | Details |
| 11438580 | Katchanov J, Harms C, Gertz K, Hauck L, Waeber C, Hirt L, Priller J, von Harsdorf R, Bruck W, Hortnagl H, Dirnagl U, Bhide PG, Endres M: Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death. J Neurosci. 2001 Jul 15;21(14):5045-53. The loss of Cdk inhibitors is followed by upregulation of cyclin D1, activation of Cdk2, and subsequent cytoskeletal disintegration. |
1(0,0,0,1) | Details |
| 11052627 | Lu K, Shih C, Teicher BA: Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents. Cancer Chemother Pharmacol. 2000;46(4):293-304. Expression of pRb, cyclin D1, cdk4, cyclin E, cdk2, E2F1 and DP-1 was determined in MCF-7 and MDA-MB-468 breast carcinoma cells, H460 and Calu-6 non-small cell lung carcinoma cells, H82 and SW2 small cell lung carcinoma cells, HCT116 and HT29 colon carcinoma cells and LNCaP and DU-145 prostate carcinoma cells. |
1(0,0,0,1) | Details |
| 10542199 | Choi KS, Eom YW, Kang Y, Ha MJ, Rhee H, Yoon JW, Kim SJ: Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. J Biol Chem. 1999 Nov 5;274(45):31775-83. TGF-beta1 induced a transient increase in the expression of Cdc2, cyclin A, cyclin B, and cyclin D1 at an early phase of apoptosis. |
1(0,0,0,1) | Details |
| 19368812 | Fei XF, Qin ZH, Xiang B, Li LY, Han F, Fukunaga K, Liang ZQ: Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of Brain Res. 2009 Apr 6;1264:85-97. Epub 2009 Feb 6. Using immunocytochemistry and real-time PCR we demonstrated that cyclin D1, cyclin B1 and proliferating cell nuclear antigen (PCNA) were aberrantly expressed in some dopaminergic neurons after 6-OHDA infusion. |
1(0,0,0,1) | Details |
| 15640940 | Knillova J, Bouchal J, Hlobilkova A, Strnad M, Kolar Z: Synergic effects of the cyclin-dependent kinase (CDK) inhibitor olomoucine and androgen-antagonist bicalutamide on prostatic cancer cell lines. Neoplasma. 2004;51(5):358-67. The proliferation arrest was accompanied by a decrease in cyclin D1 expression and the activation of p21Waf1/Cip1 and p27Kip1 pathways in both cell lines. |
1(0,0,0,1) | Details |