| Name | caspase (protein family or complex) |
|---|---|
| Synonyms | caspase; caspases |
| Name | kinetin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15051486 | Ribas J, Boix J: Cell differentiation, caspase inhibition, and macromolecular synthesis blockage, but not BCL-2 or BCL-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs. Exp Cell Res. 2004 Apr 15;295(1):9-24. However, a partial protective effect was detected when cells were treated with a general inhibitor of caspases (zVADfmk), cycloheximide (CHX), or actinomycin D (DAct). |
1(0,0,0,1) | Details |
| 18761330 | Wesierska-Gadek J, Hajek SB, Sarg B, Wandl S, Walzi E, Lindner H: Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells. Biochem Pharmacol. 2008 Dec 1;76(11):1503-14. Epub 2008 Aug 12. Moreover, ROSC induces in human MCF-7 cells phosphorylation of p53 protein at Ser-46 which in turn initiates caspase-independent apoptosis. |
1(0,0,0,1) | Details |
| 19138471 | Zhou Y, Guo YJ, Liu X, Mei YW: Cell cycle inhibitor enhances the resolution of HSV-1-induced proinflammatory response in murine microglial cells. Neurol Res. 2009 Nov;31(9):910-6. Epub 2009 Jan 9. RESULTS: The following are the results of this work: (1) olomoucine reduced HSV-1-induced proliferation associated cyclin D1 expression; (2) olomoucine also induced microglial cells apoptosis early at 24 hours post-infection and inhibited the release of proinflammatory cytokine and chemokine, including tumor necrosis factor alpha and monocyte chemoattractant protein 1; and (3) olomoucine-induced apoptosis was caspase-dependent, and it also reduced the antiapoptotic protein Mcl-1. |
1(0,0,0,1) | Details |
| 16530228 | Appert-Collin A, Hugel B, Levy R, Niederhoffer N, Coupin G, Lombard Y, Andre P, Poindron P, Gies JP: Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons. Life Sci. 2006 Jun 27;79(5):484-90. Epub 2006 Mar 10. Similarly, release of apoptotic microparticles and activation of caspases-3 and -9 were observed within the first hours following neurotrophic factor withdrawal. |
1(0,0,0,1) | Details |
| 11708719 | Hipkiss AR: On the "struggle between chemistry and biology during aging"--implications for DNA repair, apoptosis and proteolysis, and a novel route of intervention. Biogerontology. 2001;2(3):173-8. Spontaneous racemization and isomerization of aspartic acid and deamidation of to four possible forms of aspartic acid in caspases and their substrates could profoundly alter apoptotic activity. Finally, it is pointed out that three recently described agents that delay senescence in cultured cells (aminoguanidine, N-t-butylhydroxylamine and kinetin) resemble in that they are also likely to react with glycoxidised proteins, as well as possess anti-oxidant activity. |
1(0,0,0,1) | Details |
| 12685824 | Honma Y, Ishii Y: Differentiation of human myeloid leukemia cells by plant redifferentiation-inducing hormones. Leuk Lymphoma. 2002 Sep;43(9):1729-35. Cytokinins such as kinetin, isopentenyladenine (IPA) and benzyladenine were very effective at inducing nitroblue tetrazolium (NBT) reduction and morphological changes in human myeloid leukemia cells into mature granulocytes. When the cells were incubated with cytokinin ribosides in the presence of an O2- scavenger, antioxidant or caspase inhibitor, apoptosis was significantly reduced and differentiation was greatly enhanced. |
1(0,0,0,1) | Details |
| 20139069 | Choi BH, Feng L, Yoon HS: FKBP38 protects Bcl-2 from caspase-dependent degradation. . J Biol Chem. 2010 Mar 26;285(13):9770-9. Epub 2010 Feb 5. We showed that the overexpression of FKBP38 attenuates reduction rate of Bcl-2, thus resulting in an increment of the intracellular Bcl-2 level, contributing to the resistance of apoptotic cell death induced by the treatment of kinetin riboside, an anticancer drug. |
4(0,0,0,4) | Details |
| 11303913 | Nagano M, Ui-Tei K, Suzuki H, Piao Z, Miyata Y: CDK inhibitors suppress apoptosis induced by chemicals and by excessive expression of a cell death gene, reaper, in Drosophila cells. Apoptosis. 2000 Dec;5(6):543-50. Increases of caspase activity induced by actinomycin D, cycloheximide, H-7 or A23187 in a Drosophila neuronal cell line, ML-DmBG2-c2, and induced by excessive expression of a Drosophila cell death gene, reaper, in Drosophila S2 cells were suppressed by 24-h pretreatment of each CDK inhibitor. |
3(0,0,0,3) | Details |
| 11313870 | Kim SG, Kim SN, Jong HS, Kim NK, Hong SH, Kim SJ, Bang YJ: Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells. Oncogene. 2001 Mar 8;20(10):1254-65. |
2(0,0,0,2) | Details |
| 15827328 | Jiang H, Zhang L, Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Hunter TJ, Corcoran GB, Seidman MD, Levine RA: -induced apoptotic death in human U251 glioma cells. Mol Cancer Ther. 2005 Apr;4(4):554-61. induces activation of caspase-3 and increases the cleavage of the downstream caspase substrate, poly (ADP- polymerase. |
1(0,0,0,1) | Details |
| 16082214 | Cernak I, Stoica B, Byrnes KR, Di Giovanni S, Faden AI: Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle. 2005 Sep;4(9):1286-93. Epub 2005 Sep 15. In mitotic cells, such as astroglia and microglia, they induce proliferation, whereas in post-mitotic cells such as neurons they initiate caspase-related apoptosis. |
1(0,0,0,1) | Details |
| 11801528 | Ishii Y, Hori Y, Sakai S, Honma Y: Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones. Cell Growth Differ. 2002 Jan;13(1):19-26. Cytokinins such as kinetin, isopentenyladenine, and benzyladenine were very effective in inducing nitroblue tetrazolium reduction and morphological changes in the cells into mature granulocytes. When the cells were incubated with cytokinin ribosides in the presence of O (2)(-) scavenger, antioxidant or caspase inhibitor, apoptosis was significantly reduced and differentiation was greatly enhanced. |
1(0,0,0,1) | Details |