| Name | CDK1 |
|---|---|
| Synonyms | CDC 2; CDC2; CDC28A; CDK 1; CDK1; Cdc2 kinase; Cell cycle controller CDC2; Cell division control protein 2 homolog… |
| Name | kinetin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16029936 | Sirotkin AV, Grossmann R: The role of protein kinase A and cyclin-dependent (CDC2) kinase in the control of basal and IGF-II-induced proliferation and secretory activity of chicken ovarian cells. Anim Reprod Sci. 2006 Mar;92(1-2):169-81. Epub 2005 Jul 18. |
6(0,0,0,6) | Details |
| 9344580 | Schutte B, Nieland L, van Engeland M, Henfling ME, Meijer L, Ramaekers FC: The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics. Exp Cell Res. 1997 Oct 10;236(1):4-15. Similarly, roscovitine, another CDK inhibitor with a 10-fold higher efficiency for both CDK1 and CDK2 as compared to olomoucine, showed the same effects at a 10-fold lower concentration. |
3(0,0,0,3) | Details |
| 9122166 | Kwon YG, Lee SY, Choi Y, Greengard P, Nairn AC: Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2168-73. |
3(0,0,0,3) | Details |
| 11726805 | Milton NG: Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase. Neuroreport. 2001 Dec 4;12(17):3839-44. |
3(0,0,0,3) | Details |
| 10896313 | Furet P, Zimmermann J, Capraro HG, Meyer T, Imbach P: Structure-based design of potent CDK1 inhibitors derived from olomoucine. J Comput Aided Mol Des. 2000 Jul;14(5):403-9. |
2(0,0,0,2) | Details |
| 14754904 | Longshaw VM, Chapple JP, Balda MS, Cheetham ME, Blatch GL: Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases. J Cell Sci. 2004 Feb 15;117(Pt 5):701-10. The mSTI1 protein can be phosphorylated in vitro by cell cycle kinases proximal to a putative nuclear localization signal (NLS), which substantiated a predicted casein kinase II (CKII)-cdc2 kinase-NLS (CcN) motif at position 180-239 and suggested that mSTI1 might move between the cytoplasm and the nucleus under certain cell cycle conditions. |
2(0,0,0,2) | Details |
| 11896531 | Vermeulen K, Strnad M, Krystof V, Havlicek L, Van der Aa A, Lenjou M, Nijs G, Rodrigus I, Stockman B, van Onckelen H, Van Bockstaele DR, Berneman ZN: Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases. Leukemia. 2002 Mar;16(3):299-305. In this study, analogues of olomoucine, a previously described plant cytokinin analogue with cyclin-dependent kinase (CDK) inhibitory activity, were investigated for effect on CDK1 and CDK2 and for effect on cell proliferation. |
2(0,0,0,2) | Details |
| 11434907 | Harmse L, van Zyl R, Gray N, Schultz P, Leclerc S, Meijer L, Doerig C, Havlik I: Structure-activity relationships and inhibitory effects of various derivatives on the in vitro growth of Plasmodium falciparum. Biochem Pharmacol. 2001 Aug 1;62(3):341-8. Our results show considerable variation in the sensitivity of P. falciparum to the different purines, as well as a general independence from their effect on purified starfish CDK1/cyclin B activity, which has been the standard assay used to identify CDK-specific inhibitors. |
2(0,0,0,2) | Details |
| 10465404 | Legraverend M, Ludwig O, Bisagni E, Leclerc S, Meijer L, Giocanti N, Sadri R, Favaudon V: Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors. Bioorg Med Chem. 1999 Jul;7(7):1281-93. Novel C-2, C-6, N-9 trisubstituted purines derived from the olomoucine/roscovitine lead structure were synthesized and evaluated for their ability to inhibit starfish oocyte CDK1/cyclin B, neuronal CDK5/p35 and erk1 kinases in purified extracts. |
2(0,0,0,2) | Details |
| 9990463 | Imbach P, Capraro HG, Furet P, Mett H, Meyer T, Zimmermann J: 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. Bioorg Med Chem Lett. 1999 Jan 4;9(1):91-6. |
2(0,0,0,2) | Details |
| 12392733 | Krystof V, Lenobel R, Havlicek L, Kuzma M, Strnad M: Synthesis and biological activity of olomoucine II. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3283-6. Based on our previous experiences with synthesis of purines, novel 2,6,9-trisubstituted derivatives were prepared and assayed for the ability to inhibit CDK1/cyclin B kinase. |
2(0,0,0,2) | Details |
| 8987615 | Zhang K, Letham DS, John PC: Cytokinin controls the cell cycle at mitosis by stimulating the dephosphorylation and activation of p34cdc2-like H1 histone kinase. Planta. 1996;200(1):2-12. In suspension-cultured N. plumbaginifolia Viv., cytokinin (kinetin) was stringently required only in late G2 phase of the cell division cycle (cdc) and cells lacking kinetin arrested in G2 phase with inactive p34cdc2-like H1 histone kinase. Control of the Cdc2 kinase by inhibitory phosphorylation was indicated by high phosphotyrosine in the inactive enzyme of arrested pith and suspension cells. |
1(0,0,0,1) | Details |
| 9779816 | Cheng TJ, Lai YK: Identification of mitogen-activated protein kinase-activated protein kinase-2 as a vimentin kinase activated by okadaic acid in 9L rat brain tumor cells. J Cell Biochem. 1998 Nov 1;71(2):169-81. With specific protein kinase inhibitors, we show the possible involvement of the cdc2 kinase- and p38 mitogen-activated protein kinase (p38MAPK)-mediated pathways in this process. |
1(0,0,0,1) | Details |
| 9288122 | Iseki H, Ko TC, Xue XY, Seapan A, Hellmich MR, Townsend CM Jr: Cyclin-dependent kinase inhibitors block proliferation of human gastric cancer cells. Surgery. 1997 Aug;122(2):187-94; discussion 194-5. The purpose of this study was to determine (1) whether olomoucine and roscovitine inhibit Cdk2 and cdc2 kinase activities of the human gastric cancer cell line SIIA and (2) whether olomoucine and roscovitine block cell proliferation and cell cycle progression. |
1(0,0,0,1) | Details |
| 7523194 | Glab N, Labidi B, Qin LX, Trehin C, Bergounioux C, Meijer L: Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions. FEBS Lett. 1994 Oct 17;353(2):207-11. |
1(0,0,0,1) | Details |
| 10567774 | Fan S, Duba DE, O'Connor PM: Cellular effects of olomoucine in human lymphoma cells differing in p53 function. Chemotherapy. 1999 Nov-Dec;45(6):437-45. In this study we investigated the cellular effects of olomoucine in two human Burkitt's lymphoma cell lines, WMN (containing wild-type p53) and CA46 (containing mutant p53), and found that in consistency with its ability to block the activity of cyclin E/Cdk2 and cyclin B1/Cdc2 kinases, olomoucine caused cell cycle arrest at both G1/S and G2/S boundaries. |
1(0,0,0,1) | Details |
| 11237594 | Haidweger E, Novy M, Rotheneder H: Modulation of Sp1 activity by a cyclin A/CDK complex. . J Mol Biol. 2001 Feb 16;306(2):201-12. Addition of olomoucine, a specific inhibitor of CDK2 and CDC2 activity on the other hand reduces the expression of the reporter. |
1(0,0,0,1) | Details |
| 9398433 | Eckberg WR: MAP and cdc2 kinase activities at germinal vesicle breakdown in Chaetopterus. Dev Biol. 1997 Nov 15;191(2):182-90. |
1(0,0,0,1) | Details |
| 10495356 | Gray N, Detivaud L, Doerig C, Meijer L: ATP-site directed inhibitors of cyclin-dependent kinases. . Curr Med Chem. 1999 Sep;6(9):859-75. Cyclin-dependent kinases trigger and coordinate transitions between different phases the cell division cycle (CDK1, 2, 3, 4, 6, 7). |
1(0,0,0,1) | Details |
| 15709490 | Milton NG: Phosphorylated amyloid-beta: the toxic intermediate in alzheimer's disease neurodegeneration. Subcell Biochem. 2005;38:381-402. Using an anti-sense peptide approach the human cyclin-dependent kinase-1 (CDK-1) was identified as being responsible for Abeta phosphorylation. |
1(0,0,0,1) | Details |
| 9917063 | Walker J, Minshall N, Hake L, Richter J, Standart N: The clam 3' UTR masking element-binding protein p82 is a member of the CPEB family. RNA. 1999 Jan;5(1):14-26. Two short N-terminal islands of sequence, of unknown function, are common to vertebrate CPEBs and clam p82. p82 undergoes rapid phosphorylation either directly or indirectly by cdc2 kinase after fertilization in meiotically maturing clam oocytes, prior to its degradation during the first cell cleavage. |
1(0,0,0,1) | Details |
| 7549905 | Abraham RT, Acquarone M, Andersen A, Asensi A, Belle R, Berger F, Bergounioux C, Brunn G, Buquet-Fagot C, Fagot D, et al.: Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. . Biol Cell. 1995;83(2-3):105-20. Taken together the results of this Noah's Ark approach show that olomoucine arrests cells both at the G1/S and the G2/M boundaries, consistent with the hypothesis of a prevalent effect on the cdk2 and cdc2 kinases, respectively. |
1(0,0,0,1) | Details |