| Name | cyclin |
|---|---|
| Synonyms | Cyclin; DNA polymerase delta auxillary protein; PCNA; Proliferating cell nuclear antigen; DNA polymerase delta auxillary proteins; Proliferating cell nuclear antigens |
| Name | kinetin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17243097 | Zhu Z, Zhang Q, Yu Z, Zhang L, Tian D, Zhu S, Bu B, Xie M, Wang W: Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo. Glia. 2007 Apr 1;55(5):546-58. In the cultured astrocytes, hypoxia induced a cell cycle activation that was associated with upregulation of the proliferating cell nuclear marker (PCNA). |
3(0,0,0,3) | Details |
| 16759516 | Tian DS, Wang W, Xu YL, Yu ZY, Xie MJ, Wang P, Zhang GB: [Effects of cyclin dependent protein kinase inhibitor olomoucine on the microenvironment of axonal regeneration after spinal cord injury: an experiment with rats]. Zhonghua Yi Xue Za Zhi. 2006 Apr 4;86(13):901-5. Western blotting was used to detect the expression of the cell cycle related proteins, cyclin A, cyclin B, cyclin E, and proliferating cell nuclear antigen (PCNA). |
2(0,0,0,2) | Details |
| 9030780 | De Azevedo WF, Leclerc S, Meijer L, Havlicek L, Strnad M, Kim SH: Inhibition of cyclin-dependent kinases by analogues: crystal structure of human cdk2 complexed with roscovitine. Eur J Biochem. 1997 Jan 15;243(1-2):518-26. A potent inhibitor of cdks, roscovitine [2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurin e], was identified by screening a series of C2,N6,N9-substituted adenines on purified cdc2/cyclin B. |
2(0,0,0,2) | Details |
| 11434907 | Harmse L, van Zyl R, Gray N, Schultz P, Leclerc S, Meijer L, Doerig C, Havlik I: Structure-activity relationships and inhibitory effects of various derivatives on the in vitro growth of Plasmodium falciparum. Biochem Pharmacol. 2001 Aug 1;62(3):341-8. Our results show considerable variation in the sensitivity of P. falciparum to the different purines, as well as a general independence from their effect on purified starfish CDK1/cyclin B activity, which has been the standard assay used to identify CDK-specific inhibitors. |
2(0,0,0,2) | Details |
| 9514874 | Nuckolls FJ, Khan AS, Butler R, Katula KS: Differential response of the human cyclin B1 promoter to inhibitors of the cell cycle in NIH3T3 cells. Biochem Biophys Res Commun. 1998 Mar 6;244(1):280-4. In this study, NIH3T3 cells stably transfected with a cyclin B1-luciferase reporter vector were utilized to investigate if cyclin B1 promoter activity is linked to either DNA replication or the activities of various cyclin-cyclin dependent kinases (cdks). |
2(0,0,0,2) | Details |
| 9030781 | Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, Inagaki M, Delcros JG, Moulinoux JP: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem. 1997 Jan 15;243(1-2):527-36. Among a series of C2, N6, N9-substituted adenines tested on purified cdc2/cyclin B, 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine) displays high efficiency and high selectivity towards some cyclin-dependent kinases. |
2(0,0,0,2) | Details |
| 10840869 | Flament S, Bodart JF, Bertout M, Browaeys E, Rousseau A, Vilain JP: Differential effects of 6- olomoucine and roscovitine on Xenopus oocytes and eggs. Zygote. 2000 Feb;8(1):3-14. The inhibitory properties of 6- olomoucine and roscovitine towards p34cdc2-cyclin B isolated from Xenopus eggs revealed K-IC50 values of 300, 40 and 10 microM respectively. |
1(0,0,0,1) | Details |
| 11516150 | Teo WL, Kumar P, Goh CJ, Swarup S: The expression of Brostm, a KNOTTED1-like gene, marks the cell type and timing of in vitro shoot induction in Brassica oleracea. Plant Mol Biol. 2001 Jul;46(5):567-80. Shoot meristem cells and dividing cells were marked from very early stages using in situ hybridization studies with Brostm, a Brassica homologue of the Arabidopsis SHOOTMERISTEMLESS (STM) gene, and a cyclin box-derived probe, Brocyc, respectively. |
1(0,0,0,1) | Details |
| 19368812 | Fei XF, Qin ZH, Xiang B, Li LY, Han F, Fukunaga K, Liang ZQ: Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of Brain Res. 2009 Apr 6;1264:85-97. Epub 2009 Feb 6. Using immunocytochemistry and real-time PCR we demonstrated that cyclin D1, cyclin B1 and proliferating cell nuclear antigen (PCNA) were aberrantly expressed in some dopaminergic neurons after 6-OHDA infusion. |
1(0,0,0,1) | Details |
| 10066178 | Riou-Khamlichi C, Huntley R, Jacqmard A, Murray JA: Cytokinin activation of Arabidopsis cell division through a D-type cyclin. . Science. 1999 Mar 5;283(5407):1541-4. |
2(0,0,0,2) | Details |
| 11052627 | Lu K, Shih C, Teicher BA: Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents. Cancer Chemother Pharmacol. 2000;46(4):293-304. |
1(0,0,0,1) | Details |
| 10717301 | Waters NC, Woodard CL, Prigge ST: Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparum. Mol Biochem Parasitol. 2000 Mar 15;107(1):45-55. This is the first indication that Plasmodial CDKs are partially regulated by cyclin subunits, as are human CDKs. |
1(0,0,0,1) | Details |
| 10336073 | Bossenmeyer-Pourie C, Chihab R, Schroeder H, Daval JL: Transient hypoxia may lead to neuronal proliferation in the developing mammalian brain: from apoptosis to cell cycle completion. Neuroscience. 1999;91(1):221-31. Morphological features of apoptosis, necrosis and mitosis were scored under fluorescence microscopy after nuclear staining with 4,6-diamidino-2-phenylindole, and the expression profile of proliferating cell nuclear antigen, a cofactor for DNA polymerase, was analysed by immunohistochemistry. |
1(0,0,0,1) | Details |
| 10980711 | Smits VA, Klompmaker R, Arnaud L, Rijksen G, Nigg EA, Medema RH: Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol. 2000 Sep;2(9):672-6. They contribute to the activation of cyclin B/Cdc2 and are involved in centrosome maturation and bipolar spindle formation at the onset of mitosis. |
1(0,0,0,1) | Details |
| 16000586 | Raynaud FI, Whittaker SR, Fischer PM, McClue S, Walton MI, Barrie SE, Garrett MD, Rogers P, Clarke SJ, Kelland LR, Valenti M, Brunton L, Eccles S, Lane DP, Workman P: In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res. 2005 Jul 1;11(13):4875-87. Molecular biomarkers, including RB phosphorylation and cyclin expression, were assessed by Western blotting. |
1(0,0,0,1) | Details |
| 19944738 | Choi HS, Chung SH: Roscovitine increases intracellular release and capacitative entry in PC12 cells. Neurosci Lett. 2010 Jan 18;469(1):141-4. Epub 2009 Nov 26. Cyclin-dependent kinase 5 (Cdk5), which is activated by the non-cyclin regulator p35 or p39, is a -directed serine/threonine kinase that is implicated in many physiological and pathological processes. |
1(0,0,0,1) | Details |
| 16029936 | Sirotkin AV, Grossmann R: The role of protein kinase A and cyclin-dependent (CDC2) kinase in the control of basal and IGF-II-induced proliferation and secretory activity of chicken ovarian cells. Anim Reprod Sci. 2006 Mar;92(1-2):169-81. Epub 2005 Jul 18. |
1(0,0,0,1) | Details |
| 9046330 | Havlicek L, Hanus J, Vesely J, Leclerc S, Meijer L, Shaw G, Strnad M: Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds. J Med Chem. 1997 Feb 14;40(4):408-12. Olomoucine (6-(benzylamino)-2-[(2-hydroxyethyl) amino]-9-methylpurine, OC), roscovitine (6-(benzylamino)-2 (R)-[[1-(hydroxymethyl) propyl] amino]-9-isopropylpur ine), and other N6,2,9-trisubstituted adenines were found to exert a strong inhibitory effect on the p34cdc2/cyclin B kinase. |
1(0,0,0,1) | Details |
| 9523556 | Maas JW Jr, Horstmann S, Borasio GD, Anneser JM, Shooter EM, Kahle PJ: Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase/mitogen-activated protein kinase inhibitors. J Neurochem. 1998 Apr;70(4):1401-10. Olomoucine inhibits multiple cyclin-dependent and mitogen-activated protein kinases with similar potency. |
1(0,0,0,1) | Details |
| 10465404 | Legraverend M, Ludwig O, Bisagni E, Leclerc S, Meijer L, Giocanti N, Sadri R, Favaudon V: Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors. Bioorg Med Chem. 1999 Jul;7(7):1281-93. Novel C-2, C-6, N-9 trisubstituted purines derived from the olomoucine/roscovitine lead structure were synthesized and evaluated for their ability to inhibit starfish oocyte CDK1/cyclin B, neuronal CDK5/p35 and erk1 kinases in purified extracts. |
1(0,0,0,1) | Details |
| 10542199 | Choi KS, Eom YW, Kang Y, Ha MJ, Rhee H, Yoon JW, Kim SJ: Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. J Biol Chem. 1999 Nov 5;274(45):31775-83. TGF-beta1 induced a transient increase in the expression of Cdc2, cyclin A, cyclin B, and cyclin D1 at an early phase of apoptosis. |
1(0,0,0,1) | Details |
| 10602500 | David-Pfeuty T: Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells. Oncogene. 1999 Dec 9;18(52):7409-22. At concentrations equal or superior to respectively 30- and 20-fold their in vitro IC50 values for cyclin B/Cdk1, cyclin A/Cdk2 and cyclin E/Cdk2, the Cdk inhibitors precipitately induce a dramatic nuclear accumulation of wt p53 and a delocalization of nucleolin from the nucleolus in all interphase cells, whatever their cell cycle status, acting in this way like the DNA-damaging drug, mitomycin C (7 microg/ml). |
1(0,0,0,1) | Details |
| 11254958 | Gomez EB, Santori MI, Laria S, Engel JC, Swindle J, Eisen H, Szankasi P, Tellez-Inon MT: Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins. Mol Biochem Parasitol. 2001 Mar;113(1):97-108. Lastly, using the yeast two-hybrid system we identified three novel cyclin-like proteins able to associate with TzCRK1, and demonstrate that two of these cyclins also bind the T. cruzi CRK3 protein, indicating that these two CRKs are cyclin-dependent kinases. |
1(0,0,0,1) | Details |
| 9917063 | Walker J, Minshall N, Hake L, Richter J, Standart N: The clam 3' UTR masking element-binding protein p82 is a member of the CPEB family. RNA. 1999 Jan;5(1):14-26. Activation of the oocyte by fertilization leads to translational activation of the abundant cyclin and ribonucleotide reductase mRNAs at a time when they undergo cytoplasmic polyadenylation. |
1(0,0,0,1) | Details |
| 12392733 | Krystof V, Lenobel R, Havlicek L, Kuzma M, Strnad M: Synthesis and biological activity of olomoucine II. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3283-6. Based on our previous experiences with synthesis of purines, novel 2,6,9-trisubstituted derivatives were prepared and assayed for the ability to inhibit CDK1/cyclin B kinase. |
1(0,0,0,1) | Details |
| 7549905 | Abraham RT, Acquarone M, Andersen A, Asensi A, Belle R, Berger F, Bergounioux C, Brunn G, Buquet-Fagot C, Fagot D, et al.: Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. . Biol Cell. 1995;83(2-3):105-20. Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. |
1(0,0,0,1) | Details |
| 18431519 | Tiedemann RE, Mao X, Shi CX, Zhu YX, Palmer SE, Sebag M, Marler R, Chesi M, Fonseca R, Bergsagel PL, Schimmer AD, Stewart AK: Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity. J Clin Invest. 2008 May;118(5):1750-64. Mechanistically, kinetin riboside upregulated expression of transcription repressor isoforms of cAMP-response element modulator (CREM) and blocked both trans-activation of CCND2 by various myeloma oncogenes and cis-activation of translocated CCND1, suggesting induction of an overriding repressor activity that blocks multiple oncogenic pathways targeting cyclin D genes. |
35(0,1,1,5) | Details |
| 16713279 | Lee H, Auh CK, Kim D, Lee TK, Lee S: Exogenous cytokinin treatment maintains cyclin homeostasis in rice seedlings that show changes of cyclin expression when the photoperiod is rapidly changed. Plant Physiol Biochem. 2006 Apr;44(4):248-52. Epub 2006 Apr 25. Similarly, seedlings grown in the dark had decreased expression of the cyclin genes, except Os;cycB2;2, after transfer to the light, a decrease that was prevented by kinetin treatment. |
35(0,1,1,5) | Details |
| 15545295 | Sanchez Mde L, Gurusinghe SH, Bradford KJ, Vazquez-Ramos JM: Differential response of PCNA and Cdk-A proteins and associated kinase activities to benzyladenine and abscisic acid during maize seed germination. J Exp Bot. 2005 Feb;56(412):515-23. Epub 2004 Nov 15. |
6(0,0,0,6) | Details |
| 11986377 | Furukawa T, Ogura T, Zheng YJ, Tsuchiya H, Nakaya H, Katayama Y, Inagaki N: Phosphorylation and functional regulation of ClC-2 channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase. J Physiol. 2002 May 1;540(Pt 3):883-93. We show here that the volume-sensitive Cl (-) channel, ClC-2 is regulated by the M-phase-specific cyclin-dependent kinase, p34 (cdc2)/cyclin B. |
5(0,0,0,5) | Details |
| 14593798 | Gomez Roig E, Vazquez-Ramos JM: Maize DNA polymerase alpha is phosphorylated by a PCNA-associated cyclin/Cdk complex: effect of benzyladenine. J Plant Physiol. 2003 Sep;160(9):983-90. |
3(0,0,0,3) | Details |