Protein Information

Name p34
Synonyms CAK; p37; p34; CCNH; CDK activating kinase; Cyclin H; Cyclin dependent kinase activating kinase; MO15 associated protein…

Compound Information

Name kinetin
CAS

Reference List

PubMed Abstract RScore(About this table)
11986377 Furukawa T, Ogura T, Zheng YJ, Tsuchiya H, Nakaya H, Katayama Y, Inagaki N: Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase. J Physiol. 2002 May 1;540(Pt 3):883-93.


We show here that the volume-sensitive Cl (-) channel, ClC-2 is regulated by the M-phase-specific cyclin-dependent kinase, p34 (cdc2)/cyclin B.
5(0,0,0,5) Details
9268294 Trzepacz C, Lowy AM, Kordich JJ, Groden J: Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34. J Biol Chem. 1997 Aug 29;272(35):21681-4.

4(0,0,0,4) Details
11684672 Corellou F, Brownlee C, Kloareg B, Bouget FY: Cell cycle-dependent control of polarised development by a cyclin-dependent kinase-like protein in the Fucus zygote. Development. 2001 Nov;128(21):4383-92.


We have previously demonstrated that, in Fucus zygotes, various aspects of cell cycle progression are tightly controlled by cyclin-dependent kinase (CDK)-like proteins, including two PSTAIRE CDK-like proteins, p34 and p32, which are synthesised after fertilisation.
2(0,0,0,2) Details
10717301 Waters NC, Woodard CL, Prigge ST: Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparum. Mol Biochem Parasitol. 2000 Mar 15;107(1):45-55.

2(0,0,0,2) Details
12147712 Mad'arova J, Lukesova M, Hlobilkova A, Strnad M, Vojtesek B, Lenobel R, Hajduch M, Murray PG, Perera S, Kolar Z: Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines. Mol Pathol. 2002 Aug;55(4):227-34.


METHODS: The effects of olomoucine and bohemine were studied on the following parameters: (1) cell proliferation, by measurement of DNA content; (2) viability, by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) and/or XTT (2,3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide) test; and (3) the expression of p53, pRB, Bcl-2, Bax, p16, p21, p27, cyclins A, B, D1, E, p34 (cdc2), and the androgen receptor (AR), by western blot analysis.
1(0,0,0,1) Details
11251098 Corellou F, Brownlee C, Detivaud L, Kloareg B, Bouget FY: Cell cycle in the fucus zygote parallels a somatic cell cycle but displays a unique translational regulation of cyclin-dependent kinases. Plant Cell. 2001 Mar;13(3):585-98.


The cell cycle of Fucus zygotes presented the other main features of a somatic cell cycle, such as a functional spindle assembly checkpoint that targets CDKs and the regulation of the early synthesis of two PSTAIRE CDKs, p32 and p34, and the associated histone H1 kinase activity as well as the regulation of CDKs by tyrosine phosphorylation.
1(0,0,0,1) Details
9553063 Grant KM, Hassan P, Anderson JS, Mottram JC: The crk3 gene of Leishmania mexicana encodes a stage-regulated cdc2-related histone H1 kinase that associates with p12. J Biol Chem. 1998 Apr 24;273(17):10153-9.


SBCRK and histidine-tagged CRK3 activities were inhibited by the purine analogue olomoucine with an IC50 of 28 and 42 microM, respectively, 5-6-fold higher than human p34 (cdc2)/cyclinB.
1(0,0,0,1) Details