Protein Information

Name ABH2
Synonyms 2OG Fe(II) oxy DC1; ABH 2; ABH2; ALKBH 2; ALKBH2; Alkylated repair protein alkB homolog 2; Oxy DC1; hABH2…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
19173583 Yi C, Yang CG, He C: A Non-Heme Iron-Mediated Chemical Demethylation in DNA and RNA. Acc Chem Res. 2009 Jan 27.

A DNA repair protein in Escherichia coli, AlkB, corrects some of the unwanted methylations of DNA bases by a unique oxidative demethylation in which the methyl carbon is liberated as formaldehyde.
Two proteins in humans that are homologous to AlkB, ABH2 and ABH3, repair the same spectrum of lesions; another human homologue of AlkB, FTO, is linked to obesity.
4(0,0,0,4) Details
19852088 Yi C, Yang CG, He C: A non-heme iron-mediated chemical demethylation in DNA and RNA. Acc Chem Res. 2009 Apr 21;42(4):530-41.

A DNA repair protein in Escherichia coli, AlkB, corrects some of the unwanted methylations of DNA bases by a unique oxidative demethylation in which the methyl carbon is liberated as formaldehyde.
Two proteins in humans that are homologous to AlkB, ABH2 and ABH3, repair the same spectrum of lesions; another human homologue of AlkB, FTO, is linked to obesity.
4(0,0,0,4) Details