| Name | PRNP |
|---|---|
| Synonyms | ASCR; PRIP; PRP; PRNP; Prion related protein; CD230; CD230 antigen; CJD… |
| Name | formaldehyde |
|---|---|
| CAS | formaldehyde |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17455801 | Sikora J, Srbova A, Koukolik F, Matej R: Retrospective sequence analysis of the human PRNP gene from the formaldehyde-fixed paraffin-embedded tissues: report of two cases of Creutzfeldt-Jakob disease. Folia Microbiol. 2006;51(6):619-25. |
9(0,0,1,4) | Details |
| 17823401 | Nicholson EM, Kunkle RA, Hamir AN, Lebepe-Mazur S, Orcutt D: Detection of the disease-associated isoform of the prion protein in formalin-fixed tissues by Western blot. J Vet Diagn Invest. 2007 Sep;19(5):548-52. |
2(0,0,0,2) | Details |
| 18221736 | Vidal E, Tortosa R, Marquez M, Serafin A, Hidalgo J, Pumarola M: Infection of metallothionein 1+2 knockout mice with Rocky Mountain Laboratory scrapie. Brain Res. 2008 Feb 27;1196:140-50. Epub 2008 Jan 24. Since the prion protein also binds and oxidative stress is one of the events presumably triggered by PrPsc deposition, it seems plausible that MTs have a relevant role in the outcome of these neurodegenerative processes. Brains were fixed following intracardiac perfusion with 4% formaldehyde, paraffin embedded, and processed for histological, histochemical and immunohistochemical evaluation. |
1(0,0,0,1) | Details |
| 18045387 | Gale P: The prion/lipid hypothesis--further evidence to support the molecular basis for transmissible spongiform encephalopathy risk assessment. J Appl Microbiol. 2007 Dec;103(6):2033-45. Recent studies have shown that oligomeric particles comprising 14-28 prion protein (PrP) molecules are much more infectious than larger fibrils (prion rods) or indeed smaller oligomers (trimers) and PrP monomers. Here, results from deactivation studies (with alkali, heat, hexane or formaldehyde) are interpreted in terms of the infectious nucleation seed comprising 14-28 PrP molecules held together by interactions with amphipathic phospholipid (PL) or more probably sphingolipid (SL) from the host. |
1(0,0,0,1) | Details |