Protein Information

Name protein as
Synonyms A1 activator; PSAP; Protein C; CSAct; Cerebroside sulfatase activator; Cerebroside sulfate activator; Co beta glucosidase; Component C…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
19007111 Berkovitch G, Doron D, Nudelman A, Malik Z, Rephaeli A: Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. J Med Chem. 2008 Dec 11;51(23):7356-69.

The metabolically released formaldehyde from the prodrugs was the dominant factor affecting cell viability by a ROS-dependent mechanism and was responsible for rapid phosphorylation of H2AX, suppression of the cell survival protein c-myc, and transient elevation in the expression of p21. 1a, which differs from 2a by releasing butyric instead of pivalic acid, was a more potent inducer of heme and acetylated H4 expression and induced apoptosis through activation of caspase 9. 1a and 1b specifically increased the level of the photosensitizer protoporphyrin 9, leading to enhancement of cell death by photodynamic therapy (PDT).
31(0,1,1,1) Details
18287644 Jockusch H, Eberhard D: Green fluorescent protein as a tracer in chimeric tissues: the power of vapor fixation. Methods Mol Biol. 2007;411:145-54.

The fluorescence of GFP and its derivatives is retained upon fixation, but most enzyme and antigenic activities of interest will be lost in the whole sample as a consequence of formaldehyde (FA) fixation.
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19513664 Bogenhagen DF: Biochemical isolation of mtDNA nucleoids from animal cells. Methods Mol Biol. 2009;554:3-14.

Contrary to the notion that mtDNA is largely free of bound proteins, these structures are nearly as rich in protein as nuclear chromatin.
The second method uses formaldehyde to crosslink proteins to mtDNA and exposes nucleoids to treatment with harsh detergents and high salt concentrations.
1(0,0,0,1) Details
18850632 Boersema PJ, Aye TT, van Veen TA, Heck AJ, Mohammed S: Triplex protein quantification based on stable isotope labeling by peptide dimethylation applied to cell and tissue lysates. Proteomics. 2008 Nov;8(22):4624-32.

Stable isotope labeling has been performed at both the protein as well as the peptide level using either metabolic or chemical labeling.
We use three different isotopomers of formaldehyde to enable the parallel analysis of three different samples.
1(0,0,0,1) Details