Protein Information

Name IL 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
17870246 Menetski J, Mistry S, Lu M, Mudgett JS, Ransohoff RM, Demartino JA, Macintyre DE, Abbadie C: Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses. Neuroscience. 2007 Nov 9;149(3):706-14. Epub 2007 Aug 14.


Consequently, proinflammatory cytokine mRNA expression (IL-1beta, IL-6, and TNFalpha) levels were greater in skin, dorsal root ganglia (DRG), and spinal cord, whereas the anti-inflammatory cytokine (IL-10) level was lower in skin and DRG in CCL2 overexpressing mice than in control mice.
1(0,0,0,1) Details
18844117 Mu R, Xu DM, Li ZG: [Mast cells and fibroblast-like synoviocytes co-culture increases interleukin-6 secretion in rheumatoid arthritis]. Zhonghua Yi Xue Za Zhi. 2008 Apr 29;88(17):1202-5.

ELISA was used to detect the interleukin (IL)-6, an important proinflammatory cytokine. 4% formaldehyde was used to fix the FLS and LAD-2 cells and then detect the IL-6 levels in the supernatant.
10(0,0,1,5) Details
18642386 Wagner EJ, Krugner-Higby L, Heath TD: Liposome dependent delivery of S-adenosyl methionine to cells by liposomes: a potential treatment for liver disease. J Pharm Sci. 2009 Feb;98(2):573-82.

SD4 in anionic DSPG liposomes stimulated murine IL-6 production in RAW 264 cells at concentrations 25- to 30-fold lower than free drug.
Formaldehyde was determined to have potency similar to that of free SAMe chloride in CV1-P cells, suggesting that the growth inhibitory effects of SAMe may partly arise from the formation of formaldehyde.
2(0,0,0,2) Details
17969629 Dehlink E, Domig KJ, Loibichler C, Kampl E, Eiwegger T, Georgopoulos A, Kneifel W, Urbanek R, Szepfalusi Z: Heat- and formalin-inactivated probiotic bacteria induce comparable cytokine patterns in intestinal epithelial cell-leucocyte cocultures. J Food Prot. 2007 Oct;70(10):2417-21.


To further investigate the influence of inactivation treatment on cytokine production, three probiotic strains were evaluated-live, heat-inactivated, and formalin-inactivated strains-for their impact on interleukin (IL) 6, IL-8, and IL-10 production in Caco-2-leucocyte cocultures.
2(0,0,0,2) Details
18939936 Curt S, Subirade M, Rouabhia M: Production and in vitro evaluation of soy protein-based biofilms as a support for human keratinocyte and fibroblast culture. Tissue Eng Part A. 2009 Jun;15(6):1223-32.

This was supported by the high level of messenger RNA expression of interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha by the keratinocytes and of IL-6 and IL-8 by the fibroblasts.
SPI biofilms were prepared from SPI chemically treated with formaldehyde at various concentrations (0%, 1%, 2%, and 3%) as cross-linking agents.
1(0,0,0,1) Details