Protein Information

Name AlkB
Synonyms ABH; ALKBH; ALKBH 1; ALKBH1; AlkB; Alkylated DNA repair protein alkB; Alkylated DNA repair protein alkB homolog 1; hABH…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
19173583 Yi C, Yang CG, He C: A Non-Heme Iron-Mediated Chemical Demethylation in DNA and RNA. Acc Chem Res. 2009 Jan 27.

A DNA repair protein in Escherichia coli, AlkB, corrects some of the unwanted methylations of DNA bases by a unique oxidative demethylation in which the methyl carbon is liberated as formaldehyde.
37(0,1,1,7) Details
19852088 Yi C, Yang CG, He C: A non-heme iron-mediated chemical demethylation in DNA and RNA. Acc Chem Res. 2009 Apr 21;42(4):530-41.

A DNA repair protein in Escherichia coli, AlkB, corrects some of the unwanted methylations of DNA bases by a unique oxidative demethylation in which the methyl carbon is liberated as formaldehyde.
37(0,1,1,7) Details
18003660 Roy TW, Bhagwat AS: Kinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation. Nucleic Acids Res. 2007;35(21):e147. Epub 2007 Nov 14.

AlkB is a member of the non-heme iron (II) alpha-ketoglutarate-dependent dioxygenase superfamily, which removes the alkyl group through oxidation eliminating a methyl group as formaldehyde.
35(0,1,1,5) Details