Protein Information

Name lysozyme
Synonyms LYZ; LZM; Lysozyme; Lysozyme C; Lysozyme C precursor; Lysozymes; Lysozyme Cs; Lysozyme C precursors

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
18158558 Fowler CB, Cunningham RE, Waybright TJ, Blonder J, Veenstra TD, O'Leary TJ, Mason JT: Elevated hydrostatic pressure promotes protein recovery from formalin-fixed, paraffin-embedded tissue surrogates. Lab Invest. 2008 Feb;88(2):185-95. Epub 2007 Dec 24.

Mass spectrometry analysis of the recovered lysozyme yielded 70% sequence coverage, correctly identified all formaldehyde-reactive amino acids, and demonstrated hydrolysis at all of the expected trypsin cleavage sites.
37(0,1,2,2) Details
17455084 Kunder S, Calzada-Wack J, Holzlwimmer G, Muller J, Kloss C, Howat W, Schmidt J, Hofler H, Warren M, Quintanilla-Martinez L: A comprehensive antibody panel for immunohistochemical analysis of formalin-fixed, paraffin-embedded hematopoietic neoplasms of mice: analysis of mouse specific and human antibodies cross-reactive with murine tissue. Toxicol Pathol. 2007;35(3):366-75.


Only 23 (B220, BCL-2, BCL-6, CD117, CD138 (2x), CD3 (2x), CD43, CD45, CD5, CD79 alpha cy, cyclin D1, Ki-67 (2x), Mac-3, Mac-2, lysozyme, mast cell tryptase, MPO, Pax-5, TdT, and TER-119) were regarded as valuable for diagnostic evaluation.
1(0,0,0,1) Details
17530029 Fowler CB, Cunningham RE, O'Leary TJ, Mason JT: 'Tissue surrogates' as a model for archival formalin-fixed paraffin-embedded tissues. Lab Invest. 2007 Aug;87(8):836-46. Epub 2007 May 28.

However, advances in FFPE tissue-based proteomics have been hampered by inefficient methods to extract proteins from archival tissue and by an incomplete knowledge of formaldehyde-induced modifications in proteins.
Cytoplasmic proteins, such as lysozyme or ribonuclease A, at concentrations approaching the protein content in whole cells, are fixed with 10% formalin to form gelatin-like plugs.
2(0,0,0,2) Details
19339046 Verheul RJ, Amidi M, van Steenbergen MJ, van Riet E, Jiskoot W, Hennink WE: Influence of the degree of acetylation on the enzymatic degradation and in vitro biological properties of trimethylated chitosans. Biomaterials. 2009 Jun;30(18):3129-35. Epub 2009 Mar 31.

First, chitosan was partially re-acetylated using acetic anhydride followed by quantitative dimethylation using formaldehyde and sodium borohydrate.
The extent of lysozyme-catalyzed degradation of TMC, and that of its precursors chitosan and dimethyl chitosan, was highly dependent on the DA and polymers with the highest DA showed the largest decrease in molecular weight.
1(0,0,0,1) Details
19193830 Papp M, Altorjay I, Lakos G, Tumpek J, Sipka S, Dinya T, Palatka K, Veres G, Udvardy M, Lakatos PL: Evaluation of the combined application of ethanol-fixed and formaldehyde-fixed neutrophil substrates for identifying atypical perinuclear antineutrophil cytoplasmic antibodies in inflammatory bowel disease. Clin Vaccine Immunol. 2009 Apr;16(4):464-70. Epub 2009 Feb 4.

Antibodies against myeloperoxidase, proteinase-3, and other specific granule proteins (elastase, lactoferrin, cathepsin G, lysozyme, and bactericidal permeability-increasing protein) were measured by an enzyme-linked immunosorbent assay.
1(0,0,0,1) Details
17980620 Sitja-Bobadilla A, Palenzuela O, Alvarez-Pellitero P: Immune response of turbot, Psetta maxima (L.) (Pisces: Teleostei), to formalin-killed scuticociliates (Ciliophora) and adjuvanted formulations. Fish Shellfish Immunol. 2008 Jan;24(1):1-10. Epub 2007 Jun 22.


Amongst innate immune factors, serum lysozyme increased progressively in all inoculated groups.
1(0,0,0,1) Details
18469104 Paredes-Sabja D, Setlow B, Setlow P, Sarker MR: Characterization of Clostridium perfringens spores that lack SpoVA proteins and dipicolinic acid. J Bacteriol. 2008 Jul;190(13):4648-59. Epub 2008 May 9.

However, lysozyme treatment rescued these decoated spores.
Although the levels of DNA-protective alpha/beta-type, small, acid-soluble spore proteins in spoVA spores were similar to those in wild-type spores, spoVA spores exhibited markedly lower resistance to moist heat, formaldehyde, HCl, hydrogen peroxide, nitrous acid, and UV radiation than wild-type spores did.
1(0,0,0,1) Details