Protein Information

Name TP53
Synonyms Antigen NY CO 13; Cellular tumor antigen p53; LFS 1; LFS1; P53; Phosphoprotein p53; TP53; TRP53…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
19197000 Huang J, Pang J, Watanabe T, Ng HK, Ohgaki H: Whole genome amplification for array comparative genomic hybridization using DNA extracted from formalin-fixed, paraffin-embedded histological sections. J Mol Diagn. 2009 Mar;11(2):109-16. Epub 2009 Feb 5.


Using formalin-fixed, paraffin-embedded histological sections of tumors carrying known TP53 mutations, LOH 1p, LOH 10q, LOH 19q, and EGFR amplification, we first optimized the protocol so that these genetic alterations were detected after WGA.
1(0,0,0,1) Details
17939878 Chandrakanthan V, Chami O, Stojanov T, O'Neill C: Variable expressivity of the tumour suppressor protein TRP53 in cryopreserved human blastocysts. Reprod Biol Endocrinol. 2007 Oct 17;5:39.

Immediately upon thawing they were fixed in formaldehyde and subjected to immunostaining for TRP53.
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19020536 Agell L, Hernandez S, de Muga S, Lorente JA, Juanpere N, Esgueva R, Serrano S, Gelabert A, Lloreta J: KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations. Mod Pathol. 2008 Dec;21(12):1470-8. Epub 2008 Sep 19.

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18630122 Rassi H, Houshmand M, Hashemi M, Majidzadeh K, Akbari MH, Panahi MS: Application of multiplex PCR with histopathologic features for detection of familial breast cancer in formalin-fixed, paraffin-embedded histologic specimens. Tsitol Genet. 2008 Mar-Apr;42(2):55-62.


Immunohistochemical method was used to detect estrogen receptor (ER) and progesterona receptor (PR) and TP53.
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19796081 Lumachi F, Marino F, Varotto S, Basso U: Oligonucleotide probe array for p53 gene alteration analysis in DNA from formalin-fixed paraffin-embedded breast cancer tissues. Ann N Y Acad Sci. 2009 Sep;1175:89-92.


Mutations in the TP53 tumor-suppressor (p53) gene represent the most common molecular changes in various malignancies, including breast cancer (BC).
1(0,0,0,1) Details