| Name | H2AX |
|---|---|
| Synonyms | H2A.X; H2A/X; H2AFX; H2AX; H2AX histone; Histone H2A.x; gamma H2AX; H2AX histones… |
| Name | formaldehyde |
|---|---|
| CAS | formaldehyde |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19007111 | Berkovitch G, Doron D, Nudelman A, Malik Z, Rephaeli A: Novel multifunctional acyloxyalkyl ester prodrugs of display improved anticancer activity independent and dependent on photoactivation. J Med Chem. 2008 Dec 11;51(23):7356-69. The metabolically released formaldehyde from the prodrugs was the dominant factor affecting cell viability by a ROS-dependent mechanism and was responsible for rapid phosphorylation of H2AX, suppression of the cell survival protein c-myc, and transient elevation in the expression of p21. 1a, which differs from 2a by releasing butyric instead of pivalic acid, was a more potent inducer of heme and acetylated H4 expression and induced apoptosis through activation of caspase 9. 1a and 1b specifically increased the level of the photosensitizer 9, leading to enhancement of cell death by photodynamic therapy (PDT). |
81(1,1,1,1) | Details |
| 18030472 | Levovich I, Nudelman A, Berkovitch G, Swift LP, Cutts SM, Phillips DR, Rephaeli A: Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular and augmentation of reactive species. Cancer Chemother Pharmacol. 2008 Aug;62(3):471-82. Epub 2007 Nov 21. Formaldehyde-releasing prodrugs abrogated c-myc protein expression and elevated c-Jun and H2AX phosphorylation, partially reversed these changes. |
31(0,1,1,1) | Details |
| 19674975 | Nakano T, Katafuchi A, Matsubara M, Terato H, Tsuboi T, Masuda T, Tatsumoto T, Pack SP, Makino K, Croteau DL, Van Houten B, Iijima K, Tauchi H, Ide H: Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells. J Biol Chem. 2009 Oct 2;284(40):27065-76. Epub 2009 Aug 11. In contrast, HR constitutes the major pathway in tolerance of DPCs as judged from cell survival and RAD51 and gamma-H2AX nuclear foci formation. |
1(0,0,0,1) | Details |