Protein Information

Name citrate synthase
Synonyms CS; Citrate synthase; Citrate synthase mitochondrial; Citrate synthases; Citrate synthase mitochondrials

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
18984854 Johnson DT, Harris RA, French S, Aponte A, Balaban RS: Proteomic changes associated with diabetes in the BB-DP rat. Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E422-32. Epub 2008 Nov 4.

Several new hypotheses were generated by these data, including mechanisms of net cytosolic protein oxidation, formaldehyde generation by the methionine cycle, and inhibition of carbon substrate oxidation via reduction in citrate synthase and short-chain acyl-CoA dehydrogenase.
81(1,1,1,1) Details
17400748 Jahn U, Huber H, Eisenreich W, Hugler M, Fuchs G: Insights into the autotrophic CO2 fixation pathway of the archaeon Ignicoccus hospitalis: comprehensive analysis of the central carbon metabolism. J Bacteriol. 2007 Jun;189(11):4108-19. Epub 2007 Mar 30.

Pentosephosphates are formed from hexosephosphates via the suggested ribulose-monophosphate pathway, whereby formaldehyde is released from C-1 of hexose.
An incomplete citric acid cycle is operating: citrate is synthesized from oxaloacetate and acetyl-CoA by a (re)-specific citrate synthase, whereas a 2-oxoglutarate-oxidizing enzyme is lacking.
1(0,0,0,1) Details