| Name | MX2 |
|---|---|
| Synonyms | Interferon regulated resistance GTP binding protein MxB; Interferon induced GTP binding protein Mx2; MX2; MXB; Myxovirus resistance protein 2; myxovirus (influenza virus) resistance 2 (mouse); p78 related protein; second interferon induced protein p78… |
| Name | formaldehyde |
|---|---|
| CAS | formaldehyde |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17822280 | Cutts SM, Nudelman A, Pillay V, Spencer DM, Levovich I, Rephaeli A, Phillips DR: Formaldehyde-releasing prodrugs in combination with adriamycin can overcome cellular drug resistance. Oncol Res. 2005;15(4):199-213. However, in growth inhibition experiments, prodrug combinations were able to overcome Adriamycin resistance to varying degrees, and the combination of Adriamycin with selected prodrugs that release two moles of formaldehyde totally overcame resistance in HL60/MX2 cells. |
37(0,1,2,2) | Details |
| 17696516 | Kalet BT, McBryde MB, Espinosa JM, Koch TH: Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism. J Med Chem. 2007 Sep 6;50(18):4493-500. Epub 2007 Aug 16. The mechanism of doxorubicin is compared with that of doxazolidine, a doxorubicin-formaldehyde conjugate. The IC (50) for doxazolidine growth inhibition of HL-60/MX2 cells, a topoisomerase II deficient derivative of HL-60 cells, is 1420-fold lower than the IC (50) for doxorubicin, and doxazolidine induces apoptosis 15-fold better. |
1(0,0,0,1) | Details |