Protein Information

Name interleukin 4
Synonyms B cell differentiation factor gamma; B cell growth factor; B cell stimulatory factor 1; BCDF gamma; BCDFg; BCDFgamma; BCGF; BSF 1…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
19422874 De Jong WH, Arts JH, De Klerk A, Schijf MA, Ezendam J, Kuper CF, Van Loveren H: Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure. Toxicology. 2009 Jul 10;261(3):103-11. Epub 2009 May 5.

After inhalation exposure the respiratory sensitizers induced more interleukin-4 (IL-4) and interleukin (IL-10) compared to the contact sensitizers, whereas the contact sensitizers, except formaldehyde, induced relatively more interferon-gamma (IFN-gamma) production.
32(0,1,1,2) Details
19042193 Tarkowski M, Kur B, Polakowska E, Jablonska E: Comparative studies of lymph node cell subpopulations and cytokine expression in murine model for testing the potentials of chemicals to induce respiratory sensitization. Int J Occup Med Environ Health. 2008;21(3):253-62.

MATERIALS AND METHODS: On day 1 and 7, Balb/c mice received toluene-2,4-diisocyanate (TDI), trimellitic anhydride (TMA), 1-chloro-2,4-dinitrobenzene (DNCB), glutaraldehyde (GA), formaldehyde (FA), benzalkonium chloride (ChB) or vehicle.
On day 15, auricular lymph nodes (LN) were excised and used for analyzes of T-, B-cells, expression of CD44 and for the estimation of IL-4 and IFN-gamma production after in vitro stimulation with concanavalin A (ConA) and also for IL-4 and IFN-gamma mRNA expression analyses using Real-Time PCR.
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17979570 Schiltz PM, Lee GJ, Zhang JG, Hoa N, Wepsic HT, Dillman RO, Jadus MR: Human allogeneic and murine xenogeneic dendritic cells are cytotoxic to human tumor cells via two distinct pathways. Cancer Biother Radiopharm. 2007 Oct;22(5):672-83.


Human monocyte-derived dendritic cells (DCs), stimulated with granulocyte-macrophage colony-stimulating factor and interleukin-4 for 1 week, major histocompatibility complex killed human tumor cells in 24-hour cytotoxicity assays.
1(0,0,0,1) Details
19827972 Qiao Y, Li B, Yang G, Yao H, Yang J, Liu D, Yan Y, Sigsgaard T, Yang X: Irritant and adjuvant effects of gaseous formaldehyde on the ovalbumin-induced hyperresponsiveness and inflammation in a rat model. Inhal Toxicol. 2009 Oct 14.

Results: The airway reactivity, lung histological changes, pulmonary interleukin-4 secretion, and eosinophil infiltration in the OVA and FA exposed rats were significantly higher after gaseous FA exposures of 417 and 2500 ppb.
1(0,0,0,1) Details
19904815 Saito A, Tanaka H, Usuda H, Shibata T, Higashi S, Yamashita H, Inagaki N, Nagai H: Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in mice. Environ Toxicol. 2009 Nov 10.

In addition, FA exposure markedly increased the expression of interleukin-4 (IL-4), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and transient receptor potential vanilloid-1 (TRPV-1) mRNAs in the ears and IL-4 and NT-3 mRNAs in the cervical lymph nodes.
1(0,0,0,1) Details
19542471 Percopo CM, Qiu Z, Phipps S, Foster PS, Domachowske JB, Rosenberg HF: Pulmonary eosinophils and their role in immunopathologic responses to formalin-inactivated pneumonia virus of mice. J Immunol. 2009 Jul 1;183(1):604-12.


However, levels of both IL-4 and CCL3 (macrophage inflammatory protein-1alpha) in bronchoalveolar lavage fluid were markedly diminished in PVM Ag-vaccinated, PVM-infected eosinophil-deficient mice when compared with wild-type controls.
1(0,0,0,1) Details
17515642 Tsunetsugu-Yokota Y, Ato M, Takahashi Y, Hashimoto S, Kaji T, Kuraoka M, Yamamoto K, Mitsuki YY, Yamamoto T, Oshima M, Ohnishi K, Takemori T: Formalin-treated UV-inactivated SARS coronavirus vaccine retains its immunogenicity and promotes Th2-type immune responses. Jpn J Infect Dis. 2007 May;60(2-3):106-12.


Interestingly, the UV-F-V vaccine induced fewer IgG (2a) subtype antibodies and higher interleukin-4 production in vaccinated mice than did UV-V.
1(0,0,0,1) Details
17570926 Gisch K, Gehrke N, Bros M, Priesmeyer C, Knop J, Reske-Kunz AB, Sudowe S: Formalin-fixed Staphylococcus aureus particles prevent allergic sensitization in a murine model of type I allergy. Int Arch Allergy Immunol. 2007;144(3):183-96. Epub 2007 Jun 15.


RESULTS: Simultaneous application of OVA and Staphylococcus particles very efficiently inhibited production of specific IgE and IgG1 as well as secretion of IL-4 and IL-5 by splenocytes, while enhancing IgG2a formation and production of IFN-gamma, indicating a shift from a Th2 response towards a Th1-biased response.
1(0,0,0,1) Details