| Name | neuropathy target esterase |
|---|---|
| Synonyms | NTE; SWS; Neuropathy target esterase; Neurotoxic esterase; PNPLA 6; patatin like phospholipase domain containing 6; Neuropathy target esterases… |
| Name | dichlorvos |
|---|---|
| CAS | 2,2-dichloroethenyl dimethyl phosphate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8065512 | Mehl A, Schanke TM, Johnsen BA, Fonnum F: The effect of trichlorfon and other organophosphates on prenatal brain development in the guinea pig. Neurochem Res. 1994 May;19(5):569-74. The organophosphates trichlorfon, dichlorvos, dimethoate, soman, triortho-cresyl (TOCP), and the diethoxy-analogue of trichlorfon (O,O-diethyl 2,2,2-trichloro-1-hydroxyethylphosphonate, ethyl-trichlorfon), were administered to guinea pigs between day 42 and 46 of gestation. |
0(0,0,0,0) | Details |
| 10509429 | Abdelsalam EB: potential of six organophosphorus compounds in adult hens. Vet Hum Toxicol. 1999 Oct;41(5):290-2. The potential of trichlorfon, diazinon, phosmet, dichlorvos, phosphamidon and coumaphos was evaluated for their ability to inhibit brain neurotoxic esterase (NTE) activity in adult hens. |
81(1,1,1,1) | Details |
| 7302988 | Caroldi S, Lotti M: Delayed neurotoxicity caused by a single massive dose of dichlorvos to adult hens. Toxicol Lett. 1981 Oct;9(2):157-9. A moderate neuropathic response was obtained in hens 2 weeks after being given a single massive s.c. dose of dichlorvos (100 mg/kg of active ingredient in a commercial 50% formulation). 1 day after dosing inhibition of neurotoxic esterase in peripheral nerve was 79-90%, in spinal cord 70-81% and in brain 89-92%. |
81(1,1,1,1) | Details |
| 7344417 | Johnson MK: Delayed neurotoxicity - do trichlorphon and/or dichlorvos cause delayed neuropathy in man or in test animals?. Acta Pharmacol Toxicol. 1981;49 Suppl 5:87-98. In vitro the inhibitory power of dichlorvos against neurotoxic esterase of hen brain is 0.02 x the power against acetylcholinesterase. |
33(0,1,1,3) | Details |
| 7713347 | Ehrich M, Jortner BS, Padilla S: Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors. Fundam Appl Toxicol. 1995 Jan;24(1):94-101. Inhibition of neuropathy target esterase (NTE, neurotoxic esterase) and acetylcholinesterase (AChE) activities was compared in brain and spinal cords of adult While Leghorn hens and adult male Long Evan rats 4-48 hr after administration of triortho-tolyl (TOTP po, 50-500 mg/kg to hens; 300-1000 mg/kg to rats), phenyl saligenin (PSP im 0.1-2.5 mg/kg to hens; 5-24 mg/kg to rats), mipafox (3-30 mg/kg ip to hens and rats), diisopropyl phosphorofluoridate (DFP sc, 0.25-1.0 mg/kg to hens; 1-3 mg/kg to rats), dichlorvos (5-60 mg/kg ip to hens; 600-2000 mg/kg to rats), and carbaryl (300-560 mg/kg ip to hens; 30-170 mg/kg to rats). |
32(0,1,1,2) | Details |
| 11705460 | Choudhary S, Gill KD: Protective effect of nimodipine on dichlorvos-induced delayed neurotoxicity in rat brain (1). Biochem Pharmacol. 2001 Nov 1;62(9):1265-72. The delayed potential of dichlorvos was assessed in terms of neuropathy target esterase (NTE) inhibition in the brain and the subsequent development of motor incoordination at 21 days post-exposure. |
31(0,1,1,1) | Details |
| 9586870 | Sarin S, Gill KD: Biochemical and behavioral deficits in adult rat following chronic dichlorvos exposure. Pharmacol Biochem Behav. 1998 Apr;59(4):1081-6. Dichlorvos administration significantly decreased the activities of neuropathy target esterase and other carboxylesterase viz., paraoxon resistant and mipafox and paraoxon resistant esterases. |
6(0,0,1,1) | Details |
| 9268605 | Ehrich M, Correll L, Veronesi B: Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. Fundam Appl Toxicol. 1997 Jul;38(1):55-63. Inhibition of AChE was greater than inhibition of NTE, without overlap of the concentration-response curves, for OPs which are more likely to cause acute, rather than delayed, effects in vivo (e.g., chlorpyrifos-oxon, dichlorvos, and trichlorfon). |
2(0,0,0,2) | Details |
| 3952739 | Schwab BW, Richardson RJ: Lymphocyte and brain neurotoxic esterase: dose and time dependence of inhibition in the hen examined with three organophosphorus esters. Toxicol Appl Pharmacol. 1986 Mar 30;83(1):1-9. Diethyl (paraoxon), tri-2-cresyl (TOCP), methyl 2,5-dichloro-4-bromophenyl phenylphosphonothionate (leptophos), and di-n-butyl-2,2-dichlorovinyl (di-n-butyl dichlorvos, DBDCV) were used to examine the relationship between lymphocyte and brain NTE inhibition in hens. |
2(0,0,0,2) | Details |
| 8779279 | Makhaeva GF, Filonenko IV, Malygin VV: [A comparative study of the interaction of dichlorovinyl esters with a neurotoxic esterase from the brain of hens and rats]. Zh Evol Biokhim Fiziol. 1995 Jul-Aug;31(4):396-403. |
2(0,0,0,2) | Details |
| 2619560 | Moretto A, Lotti M, Spencer PS: In vivo and in vitro regional differential sensitivity of neuropathy target esterase to di-n-butyl-2,2-dichlorovinyl Arch Toxicol. 1989;63(6):469-73. |
1(0,0,0,1) | Details |
| 3351976 | Robertson DG, Mattson AM, Bestervelt LL, Richardson RJ, Anderson RJ: Time course of electrophysiologic effects induced by di-n-butyl-2,2-dichlorovinyl (DBCV) in the adult hen. J Toxicol Environ Health. 1988;23(3):283-94. These data suggest that electrophysiologic deficits occur before clinical signs of organophosphorus-induced delayed neuropathy (OPIDN) and may be indicative of a link between neurotoxic esterase (NTE) inhibition and onset of overt clinical toxicity. |
1(0,0,0,1) | Details |
| 10706244 | Huggins DJ, Richardson RJ: Brainstem axolemmal protein phosphorylation in vitro in hens dosed with di-1-butyl-2,2-dichlorovinyl J Toxicol Environ Health A. 1999 Feb 26;56(4):263-82. Neuropathy target esterase (neurotoxic esterase, NTE), a protein thought to be involved in the production of organophosphorus compound-induced delayed neurotoxicity (OPIDN), has been postulated to be a component of endogenous neuronal protein phosphorylation systems. White Leghorn hens were dosed with the neuropathic compounds di-1-butyl-2,2-dichlorovinyl (dibutyl dichlorvos, DBDCV), tri-o-cresyl (TOCP), or acrylamide, and regions from brain were fractionated into axolemmal, synaptosomal, and microsomal preparations. |
1(0,0,0,1) | Details |
| 1412529 | Moretto A, Capodicasa E, Lotti M: Clinical expression of organophosphate-induced delayed polyneuropathy in rats. Toxicol Lett. 1992 Oct;63(1):97-102. Clinical effects correlate with inhibition of neuropathy target esterase (NTE) which is considered the target for this toxicity. |
1(0,0,0,1) | Details |
| 2444671 | Moretto A, Lotti M, Sabri MI, Spencer PS: Progressive deficit of retrograde axonal transport is associated with the pathogenesis of di-n-butyl dichlorvos axonopathy. J Neurochem. 1987 Nov;49(5):1515-22. The induction of central-peripheral distal axonopathy in hens singly dosed with some organophosphorus (OP) compounds, such as di-n-butyl-2,2-dichlorovinyl (DBDCVP), requires greater than 80% organophosphorylation and subsequent intramolecular rearrangement ("aging") of a protein [neuropathy target esterase (NTE)] in the axon. |
1(0,0,0,1) | Details |
| 12619790 | Sevim S, Aktekin M, Dogu O, Ozturk H, Ertas M: Late onset polyneuropathy due to organophosphate (DDVP) intoxication. Can J Neurol Sci. 2003 Feb;30(1):75-8. This syndrome is due to inhibition of neuropathy target esterase. |
1(0,0,0,1) | Details |
| 8381002 | Peraica M, Capodicasa E, Moretto A, Lotti M: Organophosphate polyneuropathy in chicks. Biochem Pharmacol. 1993 Jan 7;45(1):131-5. Young animals are resistant to organophosphate-induced delayed neuropathy (OPIDP), although biochemical changes on Neuropathy Target Esterase (NTE) caused by neuropathic organophosphorus esters (OP) are similar to those observed in the sensitive hen. |
1(0,0,0,1) | Details |
| 2018554 | Moretto A, Capodicasa E, Peraica M, Lotti M: Age sensitivity to organophosphate-induced delayed polyneuropathy. Biochem Pharmacol. 1991 May 15;41(10):1497-504. The putative target protein in the nervous system for initiation of OPIDP in the adult hen is an enzyme called Neuropathy Target Esterase (NTE), which is dissected by selective inhibitors among nervous tissue esterases hydrolysing phenyl (PV). |
1(0,0,0,1) | Details |
| 16042503 | Lotti M, Moretto A: Organophosphate-induced delayed polyneuropathy. . Toxicol Rev. 2005;24(1):37-49. Neuropathy target esterase (NTE) is thought to be the target of OPIDP initiation. In this article, we mainly discuss OP pesticide poisoning, particularly when caused by chlorpyrifos, dichlorvos, isofenphos, methamidophos, mipafox, trichlorfon, trichlornat, phosphamidon/mevinphos and by certain carbamates. |
1(0,0,0,1) | Details |