Protein Information

Name GABA receptor (protein family or complex)
Synonyms GABA receptor; GABA receptors; GABA(A) receptor; GABA(A) receptors; Gamma aminobutyric acid receptor; Gamma aminobutyric acid receptors

Compound Information

Name imidacloprid
CAS

Reference List

PubMed Abstract RScore(About this table)
11872245 Deglise P, Grunewald B, Gauthier M: The insecticide imidacloprid is a partial agonist of the nicotinic receptor of honeybee Kenyon cells. Neurosci Lett. 2002 Mar 15;321(1-2):13-6.

Our results identify the honeybee nAChR as a target of imidacloprid and an imidacloprid-induced inhibition of the insect GABA receptor.
82(1,1,1,2) Details
12425057 Ishaaya I, Kontsedalov S, Mazirov D, Horowitz AR: Biorational agents--mechanism and importance in IPM and IRM programs for controlling agricultural pests. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2001;66(2a):363-74.

In addition, efforts have been made to develop compounds acting selectively on groups of insects by inhibiting or enhancing biochemical sites such as respiration (diafenthiuron), the nicotinyl acetylcholine receptors (imidacloprid and acetamiprid), the GABA receptors (avermectins), the salivary glands of sucking pests (pymetrozine) and others.
33(0,1,1,3) Details
16172884 Raymond-Delpech V, Matsuda K, Sattelle BM, Rauh JJ, Sattelle DB: Ion channels: molecular targets of neuroactive insecticides. Invert Neurosci. 2005 Nov;5(3-4):119-33. Epub 2005 Oct 24.

The examples discussed include, sodium channels (pyrethroids, p,p'-dichlorodiphenyl-trichloroethane (DDT), dihydropyrazoles and oxadiazines); nicotinic acetylcholine receptors (cartap, spinosad, imidacloprid and related nitromethylenes/nitroguanidines); gamma-aminobutyric acid (GABA) receptors (cyclodienes, gamma-BHC and fipronil) and L-glutamate receptors (avermectins).
31(0,1,1,1) Details
12370061 Narahashi T: Nerve membrane ion channels as the target site of insecticides. Mini Rev Med Chem. 2002 Aug;2(4):419-32.

However, the major target receptors are limited to sodium channels, GABA receptors, and nicotinic acetylcholine receptors.
Imidacloprid modulates nicotinic receptors in a complex manner.
2(0,0,0,2) Details
16044331 Barbara GS, Zube C, Rybak J, Gauthier M, Grunewald B: Acetylcholine, GABA and glutamate induce ionic currents in cultured antennal lobe neurons of the honeybee, Apis mellifera. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005 Sep;191(9):823-36. Epub 2005 Sep 13.

Epibatidine and imidacloprid are partial agonists.
Our data indicate the existence of an ionotropic GABA receptor which is permeable to chloride ions and sensitive to picrotoxin (PTX) and the insecticide fipronil.
1(0,0,0,1) Details