Protein Information

Name statins
Synonyms STN; statin; statins

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
16232003 Landsman PB, Yu W, Liu X, Teutsch SM, Berger ML: Impact of 3-tier pharmacy benefit design and increased consumer cost-sharing on drug utilization. Am J Manag Care. 2005 Oct;11(10):621-8.


Switches to lower copayments for ACE inhibitors, statins, and triptans occurred more often for cases.
2(0,0,0,2) Details
15901796 Hirano M, Maeda K, Hayashi H, Kusuhara H, Sugiyama Y: Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther. 2005 Aug;314(2):876-82. Epub 2005 May 18.


The inhibitory effects of hydrophilic statins (pravastatin and rosuvastatin) on the uptake of TCA by BSEP were relatively lower than those of lipophilic statins.
1(0,0,0,1) Details
19175937 Knight LA, Kurbacher CM, Glaysher S, Fernando A, Reichelt R, Dexel S, Reinhold U, Cree IA: Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. BMC Cancer. 2009 Jan 28;9:38.


Previous data suggest that lipophilic statins such as fluvastatin and N-bisphosphonates such as zoledronic acid, both inhibitors of the mevalonate metabolic pathway, have anti-cancer effects in vitro and in patients.
1(0,0,0,1) Details