Protein Information

Name glutathione reductase
Synonyms GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases…

Compound Information

Name dichlorvos
CAS 2,2-dichloroethenyl dimethyl phosphate

Reference List

PubMed Abstract RScore(About this table)
14568351 Pena-Llopis S, Ferrando MD, Pena JB: Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteine. Aquat Toxicol. 2003 Dec 10;65(4):337-60.

Fish pre-treated with NAC (1 mmol kg (-1), i.p.) and exposed to 1.5 mg l (-1) (the 96-h LC85) of dichlorvos for 96 h in a static-renewal system achieved an increase of the GSH content, GSH/GSSG ratio, hepatic glutathione reductase (GR), glutathione S-transferase (GST), glutamate:cysteine ligase (GCL), and gamma-glutamyl transferase (gammaGT) activities, which ameliorated the glutathione loss and oxidation, and enzyme inactivation, caused by the OP pesticide.
31(0,1,1,1) Details
18539328 Celik I, Suzek H: Effects of subacute exposure of dichlorvos at sublethal dosages on erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. Ecotoxicol Environ Saf. 2009 Mar;72(3):905-8. Epub 2008 Jun 9.

In this study, the effects of dichlorvos (DIC) at sublethal concentration on malondialdehyde (MDA) content and antioxidant defense system (ADS) such as reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), and glutathione-S-transferase (GST) in various tissues of rats exposed to 0.0225 and 0.0450 millimole (mmol) DIC in drinking water were administered orally to rats ad libitum for 28 days continuously.
6(0,0,1,1) Details
13677510 Pena-Llopis S, Ferrando MD, Pena JB: Increased recovery of brain acetylcholinesterase activity in dichlorvos-intoxicated European eels Anguilla anguilla by bath treatment with N-acetylcysteine. Dis Aquat Organ. 2003 Aug 4;55(3):237-45.

Acetylcholinesterase (AChE) and glutathione reductase (GR) activities in the brain, which were biomarkers of neurotoxicity and oxidative stress, respectively, were also highly inhibited.
1(0,0,0,1) Details