Protein Information

Name neuropeptide Y
Synonyms NPY; Neuropeptide Y; Neuropeptide Y precursor; PYY 4; PYY4; Y Neuropeptide; Neuropeptide ies; Neuropeptide Y precursors…

Compound Information

Name benzalkonium chloride
CAS quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

Reference List

PubMed Abstract RScore(About this table)
7523149 Grundemar L, Krstenansky JL, Hakanson R: Neuropeptide Y and truncated neuropeptide Y analogs evoke histamine release from rat peritoneal mast cells. Eur J Pharmacol. 1994 Jun 2;258(1-2):163-6.

Pretreatment of mast cells with pertussis toxin or benzalkonium chloride markedly inhibited the histamine release evoked by neuropeptide Y, [Aoc2-27] neuropeptide Y and compound 48/80.
119(1,2,2,9) Details
7540143 Mousli M, Trifilieff A, Pelton JT, Gies JP, Landry Y: Structural requirements for neuropeptide Y in mast cell and G protein activation. Eur J Pharmacol. 1995 Mar 15;289(1):125-33.

The histamine releasing effects of neuropeptide Y related peptides were greatly inhibited by pretreatment of rat mast cells with pertussis toxin or benzalkonium chloride.
40(0,1,1,10) Details
7536161 Emadi-Khiav B, Mousli M, Bronner C, Landry Y: Human and rat cutaneous mast cells: involvement of a G protein in the response to peptidergic stimuli. Eur J Pharmacol. 1995 Jan 5;272(1):97-102.

The hydrolysis of sialic acid residues by neuraminidase and the inhibition of G proteins by benzalkonium chloride or pertussis toxin significantly inhibited the secretory response of cutaneous mast cells to neuropeptide Y-(18-36) and mastoparan.
33(0,1,1,3) Details
7526655 Mousli M, Landry Y: Role of positive charges of neuropeptide Y fragments in mast cell activation. Agents Actions. 1994 Jun;41 Spec No:C41-2.

The histamine secretion induced by NPY fragments was inhibited by the treatment of mast cells with benzalkonium chloride and pertussis toxin indicating the involvement of G proteins.
2(0,0,0,2) Details