| Name | Rho kinase |
|---|---|
| Synonyms | NY REN 35 antigen; P160ROCK; ROCK 1; ROCK1; ROK alpha; ROKa; ROKalpha; Rho associated coiled coil containing protein kinase 1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18036192 | Maruta T, Yanagita T, Matsuo K, Uezono Y, Satoh S, Nemoto T, Yoshikawa N, Kobayashi H, Takasaki M, Wada A: Lysophosphatidic acid-LPA1 receptor-Rho-Rho kinase-induced up-regulation of Nav1.7 sodium channel mRNA and protein in chromaffin cells: enhancement of 22Na+ influx, 45Ca2+ influx and catecholamine secretion. J Neurochem. 2008 Apr;105(2):401-12. Epub 2007 Nov 25. LPA treatment (> or = 24 h) increased cell surface [3H] saxitoxin binding by approximately 28%, without altering the K (d) value; the increase was prevented by cycloheximide, actinomycin D, or Ki16425, dioctylglycerol 8:0 (two inhibitors of LPA (1) and LPA3 receptors), or botulinum toxin C3 (Rho inhibitor), Y27632 (Rho kinase inhibitor), consistent with LPA (1) receptor expression in chromaffin cells. |
33(0,1,1,3) | Details |
| 20207835 | Gonzalez-Montelongo MC, Marin R, Gomez T, Marrero-Alonso J, Diaz M: Androgens Induce Nongenomic Stimulation of Colonic Contractile Activity through Induction of Sensitization and Phosphorylation of LC20 and CPI-17. Mol Endocrinol. 2010 Mar 5. The results using flutamide, finasteride, cycloheximide, and actinomycin D indicate that androgen-induced potentiation is dependent on androgen receptors, requires reduction of to DHT, and occurs independently of transcriptional and translational events. Paralleling these findings, inhibition of Rho-associated Rho kinase (ROK) and/or protein kinase C (PKC) with, respectively, Y27632 and chelerythrine, prevented LC20 phosphorylation and abolished sensitization. |
1(0,0,0,1) | Details |
| 16946014 | Gonzalez-Montelongo MC, Marin R, Gomez T, Diaz M: Androgens differentially potentiate mouse intestinal smooth muscle by nongenomic activation of polyamine synthesis and Rho kinase activation. Endocrinology. 2006 Dec;147(12):5715-29. Epub 2006 Aug 31. Androgen-induced potentiation was prevented by preincubation with AR antagonists flutamide or cyproterone acetate but was unaffected by pretreatment with cycloheximide plus actinomycin D, indicating that potentiation was mediated by ARs via a novel nongenomic mechanism. |
2(0,0,0,2) | Details |
| 15735708 | Rodrigue CM, Porteu F, Navarro N, Bruyneel E, Bracke M, Romeo PH, Gespach C, Garel MC: The cancer chemopreventive agent induces tensin, a cell-matrix adhesion protein with signaling and antitumor activities. Oncogene. 2005 May 5;24(20):3274-84. Pharmacological blockade of PI3-kinase and Rho GTPases/Rho-kinase resulted in selective depletion of focal adhesions, disorganization of tensin localization and disruption of stress fibers. |
1(0,0,0,1) | Details |
| 17050539 | Tew SR, Hardingham TE: Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization. J Biol Chem. 2006 Dec 22;281(51):39471-9. Epub 2006 Oct 18. Here we show that endogenous SOX9 mRNA can be rapidly up-regulated in subcultured human articular chondrocytes if grown in alginate, in monolayer with cytochalasin D, or with specific inhibition of the RhoA effector kinases ROCK1 and -2, which all prevent actin stress fiber formation. Disruption of actin stress fibers using any of these redifferentiation stimuli also supported the superinduction of SOX9 by cycloheximide. |
1(0,0,0,1) | Details |
| 15946238 | Zhu MJ, Kim CD, Kwon YB, Kye KC, Chen YY, Lee WH, Lee S, Lim JS, Seo YJ, Suhr KB, Park JK, Lee JH: Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts. Exp Dermatol. 2005 Jul;14(7):509-14. Pretreatment with cycloheximide did not prevent the CTGF induction by SPC, indicating that SPC stimulates CTGF mRNA expression without the increased synthesis of a regulatory protein. |
0(0,0,0,0) | Details |