| Name | thrombin |
|---|---|
| Synonyms | Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16293985 | Sarker KP, Biswas KK, Yamaji K, Yamakuchi M, Hashiguchi T, Lee KY, Maruyama I: Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma (NB-1) cells by argatroban. Pathophysiol Haemost Thromb. 2005;34(1):41-7. In these cells, we further show that thrombin-induced VEGF secretion was blocked by cycloheximide and actinomycin D, indicating that de novo protein synthesis is essential for this process. |
88(1,1,1,8) | Details |
| 19878520 | Ohuchi N, Hayashi K, Iwamoto K, Koike K, Kizawa Y, Nukaga M, Kakegawa T, Murakami H: Thrombin-stimulated proliferation is mediated by endothelin-1 in cultured rat gingival fibroblasts. Fundam Clin Pharmacol. 2009 Oct 30. Thrombin (2.5 U/mL) induced an increase in immunoreactive ET-1 expression, which was inhibited by cycloheximide (10 mug/mL), and an increase in preproET-1 mRNA expression, as assessed by reverse transcription polymerase chain reaction. |
36(0,1,1,6) | Details |
| 17498698 | Ohnishi M, Katsuki H, Fujimoto S, Takagi M, Kume T, Akaike A: Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury. Exp Neurol. 2007 Jul;206(1):43-52. Epub 2007 Apr 14. Intracerebroventricular injection of argatroban or cycloheximide, both of which prevent thrombin cytotoxicity in vitro, exhibited a significant neuroprotective effect against ICH-induced injury. |
10(0,0,1,5) | Details |
| 18565131 | Arayatrakoollikit U, Pavasant P, Yongchaitrakul T: Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3'-kinase/mammalian target of rapamycin pathway in human periodontal ligament cells. J Periodontal Res. 2008 Oct;43(5):537-43. Epub 2008 Jun 28. The inductive effect was inhibited by cycloheximide, but not by indomethacin. |
9(0,0,0,9) | Details |
| 16330215 | Fujimoto S, Katsuki H, Kume T, Akaike A: Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures. Neurobiol Dis. 2006 Apr;22(1):130-42. Epub 2005 Dec 5. These effects were prevented by cycloheximide and actinomycin D but not by a caspase-3 inhibitor. |
5(0,0,0,5) | Details |
| 16606835 | Uzonyi B, Lotzer K, Jahn S, Kramer C, Hildner M, Bretschneider E, Radke D, Beer M, Vollandt R, Evans JF, Funk CD, Habenicht AJ: Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6326-31. Epub 2006 Apr 10. Transcripts peaked at approximately 60 min, were unaffected by a cysLT1-R antagonist, and were superinduced by cycloheximide. We also compared LTD4 effects with those induced by thrombin that binds to protease-activated receptor (PAR)-1. |
4(0,0,0,4) | Details |
| 18458045 | Camacho M, Rodriguez C, Salazar J, Martinez-Gonzalez J, Ribalta J, Escudero JR, Masana L, Vila L: induces PGI synthase expression in human endothelial cells. . J Lipid Res. 2008 Aug;49(8):1707-14. Epub 2008 May 5. We explored the effect of RA on AA metabolism in human umbilical vein endothelial cells (HUVECs). 13-cis-RA increased the release of prostaglandin I (2) (PGI (2)), both spontaneous and thrombin-induced, in terms of 6-oxo-PGF (1alpha) analyzed by enzyme-immunoassay. Actinomycin D and cycloheximide both inhibited RA-induced PGIS expression. |
1(0,0,0,1) | Details |
| 18311187 | Campos-Toimil M, Keravis T, Orallo F, Takeda K, Lugnier C: Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca (2+) responses in endothelial cells. Br J Pharmacol. 2008 May;154(1):82-92. Epub 2008 Mar 3. All these effects were suppressed by cycloheximide. KEY RESULTS: Long-term pre-treatment of HUVEC with rolipram or db-cAMP significantly increased ATP-, - and thrombin-induced [Ca (2+)](i) rises. |
1(0,0,0,1) | Details |
| 19580379 | Yang SN, Burch ML, Getachew R, Ballinger ML, Osman N, Little PJ: Growth factor-mediated hyper-elongation of glycosaminoglycan chains on biglycan requires transcription and translation. Arch Physiol Biochem. 2009 Jul;115(3):147-54. To determine if the response involves specific signalling pathways or the process of GAG hyper-elongation we have also investigated the effects of epidermal growth factor (EGF), transforming growth factor-beta (TGF-beta) and thrombin. We report that both actinomycin D and cycloheximide completely abolished the ability of PDGF to stimulate radiosulphate incorporation and GAG elongation into secreted proteoglycans, and to increase the size of xyloside GAGs. |
1(0,0,0,1) | Details |