| Name | bradykinin |
|---|---|
| Synonyms | Alpha 2 thiol proteinase inhibitor; BDK; Bradykinin; KNG; KNG 1; KNG1; Kininogen; Kininogen 1 precursor… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16696851 | Tang HB, Inoue A, Iwasa M, Hide I, Nakata Y: Substance P release evoked by or from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin. J Neurochem. 2006 Jun;97(5):1412-8. Bradykinin-evoked SP release from cultured adult rat DRG neurons was attenuated by either the mitogen-activated protein kinase kinase (MEK) inhibitor (U0126) or cycloheximide. |
37(0,1,1,7) | Details |
| 17178924 | Moreau ME, Bawolak MT, Morissette G, Adam A, Marceau F: Role of nuclear factor-kappaB and protein kinase C signaling in the expression of the kinin B1 receptor in human vascular smooth muscle cells. Mol Pharmacol. 2007 Mar;71(3):949-56. Epub 2006 Dec 18. Various stimulatory compounds that increase receptor mRNA stability only (human and bovine sera, cycloheximide) or that stimulate NF-kappaB nuclear translocation and both mRNA concentration and stability [interleukin (IL)-1beta, phorbol 12- 13- (PMA)] all increased the density of binding sites for the tritiated B1 receptor agonist [3H] -des-Arg9-bradykinin (without change in receptor affinity) in cell-based assays. |
32(0,1,1,2) | Details |
| 20006666 | Filipovich-Rimon T, Fleisher-Berkovich S: Protein synthesis dependent effects of kinins on astrocyte prostaglandin synthesis. Peptides. 2010 Apr;31(4):651-6. Epub 2009 Dec 16. However, little is known about the possible role of kinins, and especially bradykinin in brain inflammation. These kinin effects on PGE (2) synthesis were completely abrogated by actinomycin-D and cycloheximide, suggesting de novo synthesis of proteins. |
5(0,0,0,5) | Details |
| 18948121 | Lim SK, Park MJ, Jung HK, Park AY, Kim DI, Kim JC, Bae CS, Kim KY, Yoon KC, Han HJ, Park SH: Bradykinin stimulates uptake via both B1R and B2R activation in a human retinal pigment epithelial cells. Life Sci. 2008 Dec 5;83(23-24):761-70. Epub 2008 Sep 30. |
3(0,0,0,3) | Details |
| 17085545 | Pelorosso FG, Halperin AV, Palma AM, Nowak W, Errasti AE, Rothlin RP: Neutral endopeptidase up-regulation in isolated human umbilical artery: involvement in desensitization of bradykinin-induced vasoconstrictor effects. J Pharmacol Exp Ther. 2007 Feb;320(2):713-20. Epub 2006 Nov 3. Moreover, NEP activity, measured by hydrolysis of its synthetic substrate (Z----p-nitroanilide), showed a 2.4-fold increase in 5-h incubated versus 2-h incubated tissues, which was completely reversed by cycloheximide (CHX) treatment. |
1(0,0,0,1) | Details |
| 16670123 | Ehrenfeld P, Millan C, Matus CE, Figueroa JE, Burgos RA, Nualart F, Bhoola KD, Figueroa CD: Activation of kinin B1 receptors induces chemotaxis of human neutrophils. . J Leukoc Biol. 2006 Jul;80(1):117-24. Epub 2006 May 2. A reduction in the chemotactic response was observed after priming of cells in the presence of 0.5 mM cycloheximide and 10 mug/ml brefeldin A, suggesting that some protein biosynthesis is required. |
0(0,0,0,0) | Details |