Protein Information

Name IgE
Synonyms IGHE; Ig epsilon chain C region; IgE; immunoglobulin heavy constant epsilon; Ig epsilon chain C regions; IgEs; immunoglobulin heavy constant epsilons

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
20080759 Kashiwada M, Levy DM, McKeag L, Murray K, Schroder AJ, Canfield SM, Traver G, Rothman PB: IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):821-6. Epub 2009 Dec 22.

Expression of NFIL3 in NFIL3-deficient B cells restores the impairment of IgE production, and overexpression of NFIL3 in the presence of cycloheximide induces GLepsilon transcripts.
86(1,1,1,6) Details
17609340 MacGlashan DW Jr: Endocytosis, recycling, and degradation of unoccupied FcepsilonRI in human basophils. J Leukoc Biol. 2007 Oct;82(4):1003-10. Epub 2007 Jul 3.

After the initial 18-h down-regulation, the receptor could be found partially restored to the cell surface if IgE were added back to the culture +/- cycloheximide.
34(0,1,1,4) Details