Protein Information

Name beta adrenoceptors (protein family or complex)
Synonyms Beta adrenoceptor; Beta adrenoceptor; Beta adrenergic receptor; Beta adrenergic receptors; Beta adrenoceptor; Beta adrenoceptors; Beta adrenoceptors

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16238455 Li HF, Tian ZF, Qiu XQ, Wu JX, Zhang P, Jia ZJ: A study of mechanisms involved in vasodilatation induced by resveratrol in isolated porcine coronary artery. Physiol Res. 2006;55(4):365-72. Epub 2005 Oct 17.

However, the relaxation induced by resveratrol was unaffected by the estrogen receptor antagonist tamoxifen, the inhibitor of prostanoid synthesis indomethacin, the antagonist of beta-adrenoceptors propranolol or the protein synthesis inhibitor, cycloheximide.
81(1,1,1,1) Details
17438304 Sonalker PA, Jackson EK: Norepinephrine, via beta-adrenoceptors, regulates bumetanide-sensitive cotransporter type 1 expression in thick ascending limb cells. Hypertension. 2007 Jun;49(6):1351-7. Epub 2007 Apr 16.

Treatment with norepinephrine, either alone or in the presence of actinomycin D or cycloheximide, had no effect on cotransporter mRNA levels.
3(0,0,0,3) Details
16920085 Ohkuma S, Katsura M, Shibasaki M, Tsujimura A, Hirouchi M: Expression of beta-adrenergic receptor up-regulation is mediated by two different processes. Brain Res. 2006 Sep 27;1112(1):114-25. Epub 2006 Aug 22.

Although cycloheximide (CHX) decreased the bindings with or without nadolol, the extent of increase of the bindings induced by nadolol was not affected by CHX.
2(0,0,0,2) Details
19470703 Kanyo R, Price DM, Chik CL, Ho AK: Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription. Endocrinology. 2009 Sep;150(9):4221-30. Epub 2009 May 21.


Here we report Sik1 expression was induced by norepinephrine (NE) in rat pinealocytes primarily through activation of beta-adrenergic receptors, with a minor contribution from activation of alpha-adrenergic receptors.
2(0,0,0,2) Details
15585586 Ricci MR, Lee MJ, Russell CD, Wang Y, Sullivan S, Schneider SH, Brolin RE, Fried SK: Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms. Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E798-804. Epub 2004 Dec 7.

In vivo and in vitro studies indicate that beta-adrenergic receptor agonists decrease leptin release from fat cells in as little as 30 min.
Inhibition of protein synthesis with cycloheximide did not block the effect of Iso on leptin release from human adipose tissue, suggesting that the Iso effect is independent of leptin synthesis.
1(0,0,0,1) Details
18311187 Campos-Toimil M, Keravis T, Orallo F, Takeda K, Lugnier C: Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca (2+) responses in endothelial cells. Br J Pharmacol. 2008 May;154(1):82-92. Epub 2008 Mar 3.

All these effects were suppressed by cycloheximide.
Thus, isozyme-specific PDE4 inhibitors might be useful as therapeutic agents in diseases where [Ca (2+)](i) handling is altered, such as atherosclerosis, hypertension and tolerance to beta-adrenoceptor agonists.
1(0,0,0,1) Details