| Name | CXCR4 |
|---|---|
| Synonyms | C X C chemokine receptor type 4; LAP 3; LAP3; Seven transmembrane helix receptor; NPYR; CD184; CD184 antigen; CXC R4… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16777169 | Choudhary SK, Walker RM, Powell DM, Planelles V, Walsh C, Camerini D: CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection. Virology. 2006 Sep 1;352(2):268-84. Epub 2006 Jun 14. Furthermore, treatment of thymocytes with cycloheximide abrogated HIV-1-induced apoptosis, implying a requirement for de novo protein synthesis. |
0(0,0,0,0) | Details |
| 18252865 | Happel C, Steele AD, Finley MJ, Kutzler MA, Rogers TJ: DAMGO-induced expression of chemokines and chemokine receptors: the role of TGF-beta1. J Leukoc Biol. 2008 Apr;83(4):956-63. Epub 2008 Feb 5. Similarly, pretreatment with cycloheximide prevented CCL5 or CXCR4 mRNA expression, consistent with the observation that DAMGO induction of chemokine and chemokine receptor expression requires newly synthesized TGF-beta1 protein. |
33(0,1,1,3) | Details |
| 19220581 | Wu Q, Shao H, Darwin ED, Li J, Li J, Yang B, Webster KA, Yu H: Extracellular calcium increases CXCR4 expression on bone marrow-derived cells and enhances pro-angiogenesis therapy. J Cell Mol Med. 2009 Sep;13(9B):3764-73. Epub 2009 Feb 9. The effects were blocked by influx inhibitors, anti-CaR antibody and the protein synthesis inhibitor cycloheximide, but not by the CXCR4 antagonist AMD3100. |
7(0,0,0,7) | Details |
| 20178462 | Simons D, Grieb G, Hristov M, Pallua N, Weber C, Bernhagen J, Steffens G: Hypoxia-induced endothelial secretion of macrophage migration inhibitory factor and role in endothelial progenitor cell recruitment. J Cell Mol Med. 2010 Feb 22. Abstract Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine that was recently identified as a non-cognate ligand of the chemokine receptors CXCR2 and CXCR4. Early hypoxia-triggered MIF secretion was not inhibited by cycloheximide and echinomycin, inhibitors of general and HIF-1alpha-induced protein synthesis, respectively. |
4(0,0,0,4) | Details |