| Name | heme oxygenase 1 |
|---|---|
| Synonyms | HMOX 1; HMOX1; HMOX1 protein; HO; HO 1; HO1; Heme oxygenase (Decycling) 1; Heme oxygenase (Decyclizing) 1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17532486 | Lin HY, Shen SC, Lin CW, Yang LY, Chen YC: Baicalein inhibition of peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression. Biochim Biophys Acta. 2007 Jul;1773(7):1073-86. Epub 2007 Apr 22. In the present study, baicalein (BE) but not its glycoside, baicalin (BI), induced heme oxygenase-1 (HO-1) gene expression at both the mRNA and protein levels, and the BE-induced HO-1 protein was blocked by adding cycloheximide (CHX) or actinomycin D (Act D). |
5(0,0,0,5) | Details |
| 19800419 | Hwangbo C, Lee HS, Park J, Choe J, Lee JH: The anti-inflammatory effect of tussilagone, from Tussilago farfara, is mediated by the induction of heme oxygenase-1 in murine macrophages. Int Immunopharmacol. 2009 Dec;9(13-14):1578-84. Epub 2009 Oct 1. TSL-mediated HO-1 protein induction was not inhibited by treatment with actinomycin D, a transcriptional inhibitor, but by cycloheximide, a translational inhibitor. |
5(0,0,0,5) | Details |
| 18819247 | Bosio E, Seveso M, Dedja A, Luca G, Calvitti M, Calafiore R, Rigotti P, Busetto R, Ancona E, Cozzi E: protoporpyhrin reduces caspase-3,-7 enzyme activity in neonatal porcine islets, but does not inhibit cell death induced by TNF-alpha. Cell Transplant. 2008;17(6):587-98. In this light, heme-oxygenase 1 (HO-1) upregulation has been studied in both allo- and xenotransplantation models. In in vitro assessments of NPICC apoptosis, NPICC showed a high sensitivity to apoptotic stimulation using a combination of TNF-alpha and cycloheximide. |
3(0,0,0,3) | Details |
| 16806762 | Lee MS, Lee J, Kwon DY, Kim MS: Ondamtanggamibang protects neurons from oxidative stress with induction of heme oxygenase-1. J Ethnopharmacol. 2006 Nov 24;108(2):294-8. Epub 2006 May 24. |
3(0,0,0,3) | Details |
| 17189831 | Warabi E, Takabe W, Minami T, Inoue K, Itoh K, Yamamoto M, Ishii T, Kodama T, Noguchi N: Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive / species. Free Radic Biol Med. 2007 Jan 15;42(2):260-9. Epub 2006 Oct 20. We have previously reported that antioxidant response element (ARE)-regulated genes, such as heme oxygenase 1 (HO-1), sequestosome 1 (SQSTM1), and NAD (P) H quinone oxidoreductase 1 (NQO1), are induced in human umbilical vein endothelial cells (HUVEC) upon exposure to laminar shear stress. Nrf2 was rapidly degraded in cells treated with cycloheximide under static conditions, but shear stress decreased the rate of Nrf2 degradation. |
3(0,0,0,3) | Details |
| 17885094 | Canas N, Valero T, Villarroya M, Montell E, Verges J, Garcia AG, Lopez MG: protects SH-SY5Y cells from oxidative stress by inducing heme oxygenase-1 via phosphatidylinositol 3-kinase/Akt. J Pharmacol Exp Ther. 2007 Dec;323(3):946-53. Epub 2007 Sep 20. The protective effects of CS were prevented by chelerythrine, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), cycloheximide, and Sn (IV)- |
3(0,0,0,3) | Details |
| 15876423 | Chow JM, Shen SC, Huan SK, Lin HY, Chen YC: but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol. 2005 Jun 15;69(12):1839-51. These data suggest that induction of HO-1 protein may participate in the protective mechanism of QE on oxidative stress (H (2) O (2))-induced apoptosis, and reduction of intracellular ROS production and mitochondria dysfunction with blocking apoptotic events were involved. Results of Western blotting show that QE but not its glycoside rutin (RUT) and quicitrin-induced HO-1 protein expression in a time- and dose-dependent manner, and HO-1 protein induced by QE was blocked by an addition of cycloheximide or actinomycin D. |
2(0,0,0,2) | Details |
| 17606337 | Elbekai RH, El-Kadi AO: Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and Toxicol Lett. 2007 Aug;172(3):106-19. Epub 2007 May 24. A significant decrease in TCDD-mediated induction of Cyp1a1 activity was associated with an increase in HO-1 mRNA levels and a concomitant decrease in cellular heme content after all metal treatments. The metal-mediated induction of Cyp1a1 mRNA was further potentiated by the protein synthesis inhibitor, cycloheximide and the 26S proteasome inhibitor, MG-132, but completely inhibited by the RNA transcription inhibitor, actinomycin-D, implying a transcriptional regulation of the Cyp1a1 gene by the heavy metals. |
1(0,0,0,1) | Details |
| 16647178 | Chen TJ, Jeng JY, Lin CW, Wu CY, Chen YC: inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells. Toxicology. 2006 Jun 1;223(1-2):113-26. Epub 2006 Mar 22. Adding the HO-1 inhibitors, SnPP, CoPP, and ZnPP, reversed the protective effect of QUE against H (2) O (2)- and chemical anoxia-induced cell death according to the MTT assay and morphological observations. Induction of HO-1 protein expression was detected in QUE- but not RUT- or QUI-treated C6 cells, and this was prevented by cycloheximide and actinomycin D. |
2(0,0,0,2) | Details |
| 16093525 | Korashy HM, El-Kadi AO: Regulatory mechanisms modulating the expression of cytochrome P450 1A1 gene by heavy metals. Toxicol Sci. 2005 Nov;88(1):39-51. Epub 2005 Aug 10. A significant decrease in TCDD-mediated induction of Cyp1a1 activity associated with an increase in HO-1 mRNA and a decrease in cellular heme content was observed after all metals treatment. The protein synthesis inhibitor, cycloheximide, and 26S proteasome inhibitor, carbobenzoxy-L-leucyl-L-leucyl-leucinal (MG-132), super-induced the metal-mediated induction of Cyp1a1 mRNA. |
1(0,0,0,1) | Details |
| 18562925 | Mersmann J, Tran N, Zacharowski PA, Grotemeyer D, Zacharowski K: is cardioprotective in a murine model of myocardial I/R. Shock. 2008 Jul;30(1):64-8. In vitro, cells from the rat cardiomyoblast cell line H9c2 (2-1) are protected against oxidative stress by incubation with which can be abrogated by dexamethasone or cycloheximide. The antioxidant enzyme heme oxygenase 1 is up-regulated in these cells after treatment. |
1(0,0,0,1) | Details |
| 16822952 | Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW, Parfenova H: HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. Am J Physiol Cell Physiol. 2006 Nov;291(5):C897-908. Epub 2006 Jul 5. In CMVEC from mice and newborn pigs, 15 ng/ml TNF-alpha alone, or with 10 microg/ml cycloheximide (CHX) caused apoptosis detected by nuclear translocation of p65 NF-kappaB, caspase-3 activation, DNA fragmentation, cell-cell contact destabilization, and cell detachment. |
0(0,0,0,0) | Details |
| 20155807 | Yamamoto N, Izumi Y, Matsuo T, Wakita S, Kume T, Takada-Takatori Y, Sawada H, Akaike A: Elevation of heme oxygenase-1 by proteasome inhibition affords dopaminergic neuroprotection. J Neurosci Res. 2010 Feb 12. In addition, a cycloheximide chase assay demonstrated that the degradation of Flag-HO-1 protein was slowed by MG-132. |
92(1,1,1,12) | Details |
| 19653226 | Yeh CT, Chiu HF, Yen GC: Protective effect of on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells. Mol Nutr Food Res. 2009 Sep;53(9):1166-76. Actinomycin D (an RNA synthesis inhibitor) and cycloheximide (a protein synthesis inhibitor) inhibited -responsive HO-1 mRNA expression, indicating that is a requirement for transcription and de novo protein synthesis. |
87(1,1,1,7) | Details |
| 15546873 | Liu XM, Peyton KJ, Ensenat D, Wang H, Schafer AI, Alam J, Durante W: Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. J Biol Chem. 2005 Jan 14;280(2):872-7. Epub 2004 Nov 16. The induction of HO-1 by ER stress was blocked by actinomycin D or cycloheximide and was independent of any changes in HO-1 mRNA stability. |
87(1,1,1,7) | Details |
| 15965068 | Hou CC, Hung SL, Kao SH, Chen TH, Lee HM: induces heme-oxygenase expression in glomerular mesangial cells. Ann N Y Acad Sci. 2005 May;1042:235-45. -induced HO-1 protein expression was inhibited by actinomycin D and cycloheximide, suggesting that de novo transcription and translation are required in this process. |
87(1,1,1,7) | Details |
| 16814338 | Chen YC, Chow JM, Lin CW, Wu CY, Shen SC: Baicalein inhibition of oxidative-stress-induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6. Toxicol Appl Pharmacol. 2006 Oct 15;216(2):263-73. Epub 2006 May 19. In the absence of H (2) O (2), BE induces ERKs protein phosphorylation, and HO-1 protein expression induced by BE was blocked by the addition of cycloheximide, actinomycin D, and the ERK inhibitor PD98059. |
84(1,1,1,4) | Details |
| 16378625 | Wu CC, Hsu MC, Hsieh CW, Lin JB, Lai PH, Wung BS: Upregulation of heme oxygenase-1 by via the phosphatidylinositol 3-kinase/Akt and ERK pathways. Life Sci. 2006 May 15;78(25):2889-97. Epub 2005 Dec 27. Furthermore, -mediated HO-1 induction was abrogated in the presence of actinomycin D and cycloheximide, indicating that this upregulation of HO-1 occurred at the transcriptional level. |
39(0,1,1,9) | Details |
| 16480751 | Wu CC, Hsieh CW, Lai PH, Lin JB, Liu YC, Wung BS: Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein. Toxicol Appl Pharmacol. 2006 Aug 1;214(3):244-52. Epub 2006 Feb 15. Moreover, acrolein-mediated HO-1 induction is abrogated in the presence of actinomycin D and cycloheximide. |
39(0,1,1,9) | Details |
| 15870071 | Vargas MR, Pehar M, Cassina P, Martinez-Palma L, Thompson JA, Beckman JS, Barbeito L: Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. J Biol Chem. 2005 Jul 8;280(27):25571-9. Epub 2005 May 3. FGF-1 induced the expression of HO-1 in cultured rat spinal cord astrocytes, which was dependent on FGF receptor activation and prevented by cycloheximide. |
34(0,1,1,4) | Details |
| 17042977 | Li YX, Li G, Dong WP, Lu DR, Tan JM: Protection of human islets from induction of apoptosis and improved islet function with HO-1 gene transduction. Chin Med J. 2006 Oct 5;119(19):1639-45. Flow cytometry was used to detect apoptotic cells in the HO-1 group and in the control group after induction by recombinant human tumor necrosis factor-alpha (rTNFalpha) and cycloheximide (CHX) for 48 hours. |
16(0,0,1,11) | Details |
| 15544924 | Grosser N, Hemmerle A, Berndt G, Erdmann K, Hinkelmann U, Schurger S, Wijayanti N, Immenschuh S, Schroder H: The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells. Free Radic Biol Med. 2004 Dec 15;37(12):2064-71. HO-1 mRNA induction was abrogated in the presence of actinomycin D and cycloheximide. |
13(0,0,1,8) | Details |
| 17265482 | Kirino Y, Takeno M, Murakami S, Kobayashi M, Kobayashi H, Miura K, Ideguchi H, Ohno S, Ueda A, Ishigatsubo Y: Tumor necrosis factor alpha acceleration of inflammatory responses by down-regulating heme oxygenase 1 in human peripheral monocytes. Arthritis Rheum. 2007 Feb;56(2):464-75. Actinomycin D and cycloheximide were used to monitor the stability of mRNA and protein. |
10(0,0,0,10) | Details |
| 17003650 | Li Y, Li G, Dong W, Chen J, Lu D, Tan J: Transplantation of rat islets transduced with human heme oxygenase-1 gene using adenovirus vector. Pancreas. 2006 Oct;33(3):280-6. Flow cytometry was used to detect apoptotic cells after induction by recombinant human tumor necrosis factor-alpha (rTNF-alpha) and cycloheximide (CHX) for 48 hours. |
10(0,0,0,10) | Details |
| 16109301 | Abate A, Yang G, Wong RJ, Schroder H, Stevenson DK, Dennery PA: decreases hemin-mediated heme oxygenase-1 induction. Free Radic Biol Med. 2005 Sep 15;39(6):711-8. Epub 2005 Feb 26. |
9(0,0,0,9) | Details |
| 19245827 | Yan J, Yang S, Zhang J, Zhai C, Zhu T: BMP6 attenuates oxidant injury in HK-2 cells via Smad-dependent HO-1 induction. Free Radic Biol Med. 2009 May 1;46(9):1275-82. Epub 2009 Feb 23. |
8(0,0,0,8) | Details |
| 19578789 | Kamimoto M, Mizuno S, Nakamura T: Reciprocal regulation of IL-6 and IL-10 balance by HGF via recruitment of heme oxygenase-1 in macrophages for attenuation of liver injury in a mouse model of endotoxemia. Int J Mol Med. 2009 Aug;24(2):161-70. In the culture of macrophages (Raw264.7), HGF enhanced the LPS-mediated HO-1 induction, and this effect was abolished by cycloheximide, but not by actinomycin-D, thus suggesting that a post-transcriptional pathway is involved in HGF-mediated up-regulation of HO-1. |
6(0,0,0,6) | Details |
| 16704410 | Harrison EM, McNally SJ, Devey L, Garden OJ, Ross JA, Wigmore SJ: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells. FEBS J. 2006 Jun;273(11):2345-56. The induction of heme oxygenase-1 in renal adenocarcinoma cells was blocked by actinomycin D and cycloheximide and was abolished by the phosphatidylinositol 3-kinase inhibitor, LY294002, but not by the inactive analog LY303511. |
6(0,0,0,6) | Details |
| 18440740 | Song HJ, Shin CY, Oh TY, Sohn UD: The protective effect of eupatilin on indomethacin-induced cell damage in cultured feline ileal smooth muscle cells: involvement of HO-1 and ERK. J Ethnopharmacol. 2008 Jun 19;118(1):94-101. Epub 2008 Mar 22. Pretreatment of ISMC with cycloheximide, an inhibitor of protein synthesis, attenuated the cytoprotective effect of eupatilin, suggesting that eupatilin induces proteins that are responsible for the cytoprotection. Heme oxygenase-1 (HO-1), which is known as a cytoprotective enzyme due to its anti-inflammatory actions, is a candidate protein since ZnPP, an HO-1 inhibitor, repressed the protective effect of eupatilin on indomethacin-induced cell damage in a concentration-dependent manner. |
4(0,0,0,4) | Details |
| 17122584 | Li QF, Wang XR, Yang YW, Su DS: Up-regulation of hypoxia inducible factor 1alpha by isoflurane in Hep3B cells. Anesthesiology. 2006 Dec;105(6):1211-9. Cycloheximide, an inhibitor for protein synthesis, completely abrogated the induction of HIF-1alpha protein by isoflurane. BACKGROUND: The volatile anesthetic isoflurane induces hypoxia inducible factor (HIF)-1-responsive genes heme oxygenase 1, inducible synthase, and vascular endothelial growth factor (VEGF) expression. |
4(0,0,0,4) | Details |