| Name | chemokine |
|---|---|
| Synonyms | CXCL12; Chemokine; Chemokine ligand 12; PBSF; Pre B cell growth stimulating factor; SCYB12; SDF 1 alpha; SDF 1 beta… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19439980 | Triggiani M, Granata F, Petraroli A, Loffredo S, Frattini A, Staiano RI, Monaco G, Marone G: Inhibition of secretory phospholipase A2-induced cytokine production in human lung macrophages by budesonide. Int Arch Allergy Immunol. 2009;150(2):144-55. Epub 2009 May 11. Suppression of cytokine/chemokine production by budesonide was associated with inhibition of sPLA (2)-induced ERK 1/2 and p38 activation. |
2(0,0,0,2) | Details |
| 20178462 | Simons D, Grieb G, Hristov M, Pallua N, Weber C, Bernhagen J, Steffens G: Hypoxia-induced endothelial secretion of macrophage migration inhibitory factor and role in endothelial progenitor cell recruitment. J Cell Mol Med. 2010 Feb 22. MIF is expressed and secreted from endothelial cells (ECs) following atherogenic stimulation, exhibits chemokine-like properties, and promotes the recruitment of leukocytes to atherogenic endothelium. Early hypoxia-triggered MIF secretion was not inhibited by cycloheximide and echinomycin, inhibitors of general and HIF-1alpha-induced protein synthesis, respectively. |
2(0,0,0,2) | Details |
| 15792835 | Gabrilovac J, Breljak D, Cupic B, Ambriovic-Ristov A: Regulation of aminopeptidase N (EC 3.4.11.2; APN; CD13) by interferon-gamma on the HL-60 cell line. Life Sci. 2005 Apr 22;76(23):2681-97. The delayed up-regulation of CD13/APN (observed after 72 and/or 96 hrs), required de novo protein synthesis as it could be abrogated by cycloheximide, an inhibitor of protein synthesis. Membrane-bound peptidases play important roles in the regulation of local concentrations of various signalling peptides such as the growth factors, hormones, chemokines and cytokines. |
1(0,0,0,1) | Details |
| 19447459 | Mikulak J, Gianolini M, Versmisse P, Pancino G, Lusso P, Verani A: Biological and physical characterization of the X4 HIV-1 suppressive factor secreted by LPS-stimulated human macrophages. Virology. 2009 Jul 20;390(1):37-44. Epub 2009 May 17. Here, we used X4 HIV-1 strains as specific probes to investigate the biological and physical characteristics of MDAF without the confounding effect of CCR5-binding chemokines. MDAF is sensitive to heat and proteinase K treatment, and it appears to be preformed within MDM, in that it is rapidly released upon LPS stimulation and its production is insensitive to cycloheximide, an inhibitor of protein neosynthesis. |
1(0,0,0,1) | Details |
| 17900782 | Kumagai K, Kiyosawa N, Ito K, Yamoto T, Teranishi M, Nakayama H, Manabe S: Influence of Kupffer cell inactivation on cycloheximide-induced hepatic injury. Toxicology. 2007 Nov 30;241(3):106-18. Epub 2007 Aug 25. On the other hand, the hepatic mRNA levels of chemokines and adhesion molecules such as Ccl20, LOX-1, and E-selectin were significantly increased only in the GdCl (3)/CHX group. |
1(0,0,0,1) | Details |
| 16705092 | Kim JS, Kim JG, Moon MY, Jeon CY, Won HY, Kim HJ, Jeon YJ, Seo JY, Kim JI, Kim J, Lee JY, Kim PH, Park JB: Transforming growth factor-beta1 regulates macrophage migration via RhoA. Blood. 2006 Sep 15;108(6):1821-9. Epub 2006 May 16. Cycloheximide, actinomycin D, and antibodies against MIP-1alpha and monocyte chemoattractant protein-1 (MCP-1) abolished the stimulation of cell migration by TGF-beta1. These findings suggest that migration of these cells is regulated directly and indirectly via the expression of chemokines such as MIP-1alpha and MCP-1 mediated by RhoA in response to TGF-beta1. |
1(0,0,0,1) | Details |
| 17208589 | Ito I, Laporte JD, Fiset PO, Asai K, Yamauchi Y, Martin JG, Hamid Q: Downregulation of a disintegrin and metalloproteinase 33 by IFN-gamma in human airway smooth muscle cells. J Allergy Clin Immunol. 2007 Jan;119(1):89-97. Epub 2006 Oct 23. Further studies using cycloheximide and actinomycin-D suggested that the downregulation was at the transcriptional level. OBJECTIVE: To investigate whether ADAM33 is more highly expressed in ASM cells of patients with asthma than in those of normal subjects, and whether there is any inflammatory mediator (asthma-related cytokine/chemokine) that could modulate the expression of ADAM33 in ASM cells. |
1(0,0,0,1) | Details |
| 19220581 | Wu Q, Shao H, Darwin ED, Li J, Li J, Yang B, Webster KA, Yu H: Extracellular calcium increases CXCR4 expression on bone marrow-derived cells and enhances pro-angiogenesis therapy. J Cell Mol Med. 2009 Sep;13(9B):3764-73. Epub 2009 Feb 9. CXCR4 is an important receptor that regulates homing of leucocytes and endothelial progenitors in response to the chemokine stromal cell-derived factor-1 (SDF-1). The effects were blocked by influx inhibitors, anti-CaR antibody and the protein synthesis inhibitor cycloheximide, but not by the CXCR4 antagonist AMD3100. |
1(0,0,0,1) | Details |
| 16951370 | Rahman MS, Yamasaki A, Yang J, Shan L, Halayko AJ, Gounni AS: IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways. J Immunol. 2006 Sep 15;177(6):4064-71. In this study, we investigated the molecular mechanisms involved in IL-17A-mediated CC chemokine (eotaxin-1/CCL11) production from human airway smooth muscle (ASM) cells. Moreover, IL-17A significantly induced eotaxin-1/CCL11 release and mRNA expression, an effect that was abrogated with cycloheximide and actinomycin D treatment. |
1(0,0,0,1) | Details |
| 16084752 | Blanchard C, Durual S, Estienne M, Emami S, Vasseur S, Cuber JC: Eotaxin-3/CCL26 gene expression in intestinal epithelial cells is up-regulated by interleukin-4 and interleukin-13 via the signal transducer and activator of transcription 6. Int J Biochem Cell Biol. 2005 Dec;37(12):2559-73. Epub 2005 Jul 21. Eotaxin-3/CCL-26 belongs to a family of CC chemokines, which are potent chemoattractants for eosinophils. |
1(0,0,0,1) | Details |
| 16264039 | Tsuji K, Yamamoto S, Ou W, Nishi N, Kobayashi I, Zaitsu M, Muro E, Sadakane Y, Ichimaru T, Hamasaki Y: dsRNA enhances eotaxin-3 production through interleukin-4 receptor upregulation in airway epithelial cells. Eur Respir J. 2005 Nov;26(5):795-803. Poly (IC)-induced upregulation of IL-4Ralpha was inhibited by treatment with cycloheximide or dexamethasone. The production of chemokines from the cells was investigated. |
1(0,0,0,1) | Details |
| 18337562 | Murooka TT, Rahbar R, Platanias LC, Fish EN: CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood. 2008 May 15;111(10):4892-901. Epub 2008 Mar 12. The multistep, coordinated process of T-cell chemotaxis requires chemokines, and their chemokine receptors, to invoke signaling events to direct cell migration. Cycloheximide, but not actinomycin D, significantly reduced chemotaxis, suggesting a possible role for mRNA translation in T-cell migration. |
1(0,0,0,1) | Details |
| 16790802 | Bennouna S, Sukhumavasi W, Denkers EY: Toxoplasma gondii inhibits toll-like receptor 4 ligand-induced mobilization of intracellular tumor necrosis factor alpha to the surface of mouse peritoneal neutrophils. Infect Immun. 2006 Jul;74(7):4274-81. Neutrophils are well-known to rapidly respond to infection through chemotactic infiltration at sites of inflammation, followed by rapid release of microbicidal molecules, chemokines, and proinflammatory cytokines. In contrast to intermediate inhibitory effects in nontreated neutrophils, T. gondii induced a complete blockade in LPS-induced surface TNF-alpha expression in the presence of the protein synthesis inhibitor cycloheximide. |
1(0,0,0,1) | Details |
| 19476648 | Yang RH, Strong JA, Zhang JM: NF-kappaB mediated enhancement of currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons. Mol Pain. 2009 May 28;5:26. The increase in K currents was completely blocked by co-incubation with protein synthesis inhibitor cycloheximide (CHX) or NF-kappaB inhibitors pyrrolidine dithiocarbamate (PDTC) or quinazoline (6-Amino-4-(4-phenoxypheny lethylamino;QNZ). |
1(0,0,0,1) | Details |
| 16125142 | Sugiyama T, Yoshimoto T, Hirono Y, Suzuki N, Sakurada M, Tsuchiya K, Minami I, Iwashima F, Sakai H, Tateno T, Sato R, Hirata Y: increases osteopontin gene expression in rat endothelial cells. Biochem Biophys Res Commun. 2005 Oct 14;336(1):163-7. The -induced osteopontin mRNA expression was completely blocked by a transcription inhibitor, actinomycin D, and a protein synthesis inhibitor, cycloheximide. |
0(0,0,0,0) | Details |
| 17182689 | Mangino G, Percario ZA, Fiorucci G, Vaccari G, Manrique S, Romeo G, Federico M, Geyer M, Affabris E: In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the release of beta interferon. J Virol. 2007 Mar;81(6):2777-91. Epub 2006 Dec 20. Previously, we reported that Nef treatment of primary human monocyte-derived macrophages (MDMs) induces a cycloheximide-independent activation of NF-kappaB and the synthesis and secretion of a set of chemokines/cytokines that activate STAT1 and STAT3. |
81(1,1,1,1) | Details |
| 17389578 | Morrison PT, Thomas LH, Sharland M, Friedland JS: RSV-infected airway epithelial cells cause biphasic up-regulation of CCR1 expression on human monocytes. J Leukoc Biol. 2007 Jun;81(6):1487-95. Epub 2007 Mar 27. Respiratory syncytial virus (RSV) infection can cause extensive airway inflammation, which is orchestrated by chemokines and their receptors. Intracellular staining revealed little internal sequestration of CCR1 protein, and CCR1 up-regulation was inhibited by actinomycin D and cycloheximide, indicating that both waves of RSV-CM-induced surface CCR1 expression were dependent on de novo transcription and protein synthesis. |
2(0,0,0,2) | Details |
| 18252865 | Happel C, Steele AD, Finley MJ, Kutzler MA, Rogers TJ: DAMGO-induced expression of chemokines and chemokine receptors: the role of TGF-beta1. J Leukoc Biol. 2008 Apr;83(4):956-63. Epub 2008 Feb 5. Similarly, pretreatment with cycloheximide prevented CCL5 or CXCR4 mRNA expression, consistent with the observation that DAMGO induction of chemokine and chemokine receptor expression requires newly synthesized TGF-beta1 protein. |
34(0,1,1,4) | Details |
| 15869948 | Strachan GD, Kopp AS, Koike MA, Morgan KL, Jordan-Sciutto KL: Chemokine- and neurotrophic factor-induced changes in E2F1 localization and phosphorylation of the retinoblastoma susceptibility gene product (pRb) occur by distinct mechanisms in murine cortical cultures. Exp Neurol. 2005 Jun;193(2):455-68. |
7(0,0,0,7) | Details |
| 15877607 | Kim HY, Kim HK, Kim JR, Kim HS: Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14- in mouse peritoneal macrophages. Immunol Cell Biol. 2005 Jun;83(3):286-93. |
2(0,0,0,2) | Details |
| 19302817 | N'Diaye M, Le Ferrec E, Kronenberg F, Dieplinger H, Le Vee M, Fardel O: TNFalpha- and NF-kappaB-dependent induction of the chemokine CCL1 in human macrophages exposed to the atherogenic lipoprotein (a). Life Sci. 2009 Mar 27;84(13-14):451-7. Epub 2009 Feb 2. KEY FINDINGS: Using the AhR antagonist alpha-napthtoflavone, the translational inhibitor cycloheximide and anti-tumor necrosis factor alpha (TNFalpha) neutralizing antibodies, we demonstrated that Lp (a)-mediated mRNA induction of CCL1 occurs in an AhR-independent manner and requires de novo protein synthesis of TNFalpha. |
2(0,0,0,2) | Details |
| 15619605 | Gravel SP, Servant MJ: Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions. J Biol Chem. 2005 Mar 4;280(9):7477-86. Epub 2004 Dec 24. The transcripts of proatherosclerotic genes Ccl5 (encoding for the chemokine RANTES (regulated upon activation, normal T cell expressed and secreted)) and Cxcl10 (encoding for the chemokine IP-10 (interferon-gamma-inducible protein 10)) were induced in an IRF-3-dependent manner after HCMV infection of smooth muscle cells. |
2(0,0,0,2) | Details |
| 16118408 | Stefanovic L, Brenner DA, Stefanovic B: Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med. 2005 Sep;230(8):573-86. |
2(0,0,0,2) | Details |
| 15582587 | Bischoff DS, Zhu JH, Makhijani NS, Yamaguchi DT: KC chemokine expression by TGF-beta in C3H10T1/2 cells induced towards osteoblasts. Biochem Biophys Res Commun. 2005 Jan 14;326(2):364-70. Use of the translational inhibitor cycloheximide results in mRNA "superinduction" suggesting other factors are involved that normally function to down-regulate KC expression. |
2(0,0,0,2) | Details |
| 19699525 | Harashima A, Toraya T, Okochi A, Yamamoto M, Suzuki M, Otani T, Inoue T, Tsuji-Takayama K, Sugimoto A, Takeuchi M, Yamasaki F, Nakamura S, Kibata M: Interleukin-8 and RANTES are signature cytokines made by HOZOT, a new type of regulatory T cells. Mol Immunol. 2009 Oct;46(16):3310-9. Epub 2009 Aug 21. Interestingly, IL-8 mRNA was induced by cycloheximide treatment and RANTES showed reduced mRNA but increased protein expression by antibody stimulation. Among these cytokines, we focused on two chemokines, IL-8 and RANTES for further studies, and found that only HOZOT produced both of them at considerable levels whereas other T cell subsets, including Tregs and helper T cells, did not. |
2(0,0,0,2) | Details |
| 18816377 | Wang JG, Strong JA, Xie W, Yang RH, Coyle DE, Wick DM, Dorsey ED, Zhang JM: The chemokine CXCL1/growth related oncogene increases currents and neuronal excitability in small diameter sensory neurons. Mol Pain. 2008 Sep 24;4:38. These effects required long exposures, and were completely blocked by co-incubation with protein synthesis inhibitor cycloheximide. |
2(0,0,0,2) | Details |
| 19446037 | Safronova O, Pluemsampant S, Nakahama K, Morita I: Regulation of chemokine gene expression by hypoxia via cooperative activation of NF-kappaB and histone deacetylase. Int J Biochem Cell Biol. 2009 Nov;41(11):2270-80. Epub 2009 May 13. |
2(0,0,0,2) | Details |
| 19339694 | Salogni L, Musso T, Bosisio D, Mirolo M, Jala VR, Haribabu B, Locati M, Sozzani S: Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14. Blood. 2009 Jun 4;113(23):5848-56. Epub 2009 Apr 1. Conversely, activin A was not active on plasmacytoid dendritic cells (DCs) or mature myeloid DCs. iDC migration to activin A was phosphatidylinositol 3-kinase gamma-dependent, Bordetella pertussis toxin- and cycloheximide-sensitive, and was inhibited by M3, a viral-encoded chemokine-binding protein. These characteristics clearly differentiated the chemotactic activities of activin A from TGF-beta and classic chemokines. |
2(0,0,0,2) | Details |
| 17671691 | Kamohara H, Takahashi M, Ishiko T, Ogawa M, Baba H: Induction of interleukin-8 (CXCL-8) by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells: Impact of CXCL-8 as an autocrine growth factor. Int J Oncol. 2007 Sep;31(3):627-32. Interleukin-8 (CXCL-8) is a CXC chemokine, which plays an important role in neutrophil chemotaxis and activation. Actinomycin D suppressed and cycloheximide augmented CXCL-8 mRNA which was induced by TNF-alpha or not. |
1(0,0,0,1) | Details |
| 17606477 | MacManus CF, Pettigrew J, Seaton A, Wilson C, Maxwell PJ, Berlingeri S, Purcell C, McGurk M, Johnston PG, Waugh DJ: Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells. Mol Cancer Res. 2007 Jul;5(7):737-48. Epub 2007 Jul 2. Administration of recombinant human IL-8 induced a rapid, time-dependent increase in cyclin D1 expression in AIPC cells, a response attenuated by the translation inhibitor cycloheximide but not by the RNA synthesis inhibitor, actinomycin D. This study provides a molecular basis to support the correlation of IL-8 expression with that of cyclin D1 in human prostate cancer and suggests a mechanism by which this chemokine promotes cell proliferation. |
1(0,0,0,1) | Details |
| 19799897 | Fritz DK, Kerr C, Botelho F, Stampfli M, Richards CD: Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1. Exp Cell Res. 2009 Dec 10;315(20):3486-99. Epub 2009 Sep 30. Previous work has shown that OSM induces eosinophil accumulation in mouse lungs in vivo and stimulates the eosinophil-selective chemokine eotaxin-1 synergistically with IL-4 in vitro. |
1(0,0,0,1) | Details |