| Name | Hsp70 |
|---|---|
| Synonyms | APG 2; APG2; HS24/P52; HSP70RY; HSPA 4; HSPA4; Heat shock 70 kDa protein 4; Heat shock 70 related protein APG 2… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15832948 | Concannon CG, FitzGerald U, Holmberg CI, Szegezdi E, Sistonen L, Samali A: CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization. Cell Stress Chaperones. 2005 Spring;10(1):59-65. Inhibition of translation and de novo protein synthesis by cycloheximide resulted in Hsp70 protein levels diminishing over time in control cells, whereas its level remained constant during CD95 signaling. |
37(0,1,1,7) | Details |
| 16572728 | Balakrishnan K, De Maio A: Heat shock protein 70 binds its own messenger ribonucleic acid as part of a gene expression self-limiting mechanism. Cell Stress Chaperones. 2006 Spring;11(1):44-50. Consequently, Hsp70 expression must be tightly regulated. |
6(0,0,0,6) | Details |
| 19116451 | Lee KJ, Ha ES, Kim MK, Lee SH, Suh JS, Lee SH, Park KH, Park JH, Kim DJ, Kang D, Kim BC, Jeoung D, Kim YK, Kim HD, Hahn JH: CD36 signaling inhibits the translation of heat shock protein 70 induced by oxidized low density lipoprotein through activation of peroxisome proliferators-activated receptor gamma. Exp Mol Med. 2008 Dec 31;40(6):658-68. In this study, we investigated the role of CD36, an OxLDL receptor, and peroxisome proliferator-activated receptor gamma (PPARgamma) in OxLDL-induced Hsp70 expression. Cycloheximide studies demonstrate that troglitazone attenuates Hsp70 translation but not Hsp70 protein stability. |
4(0,0,0,4) | Details |
| 19657853 | Dong GZ, Youn H, Park MT, Oh ET, Park KH, Song CW, Choi EK, Park HJ: Heat shock increases expression of NAD (P) H:quinone oxidoreductase (NQO1), mediator of beta-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein. Int J Hyperthermia. 2009;25(6):477-87. |
4(0,0,0,4) | Details |
| 19151744 | Liu HY, Wang ZM, Bai Y, Wang M, Li Y, Wei S, Zhou QH, Chen J: Different BAG-1 isoforms have distinct functions in modulating chemotherapeutic-induced apoptosis in breast cancer cells. Acta Pharmacol Sin. 2009 Feb;30(2):235-41. Epub 2009 Jan 19. In the detection of the expression of K-ras, Hsp70, cytochrome c, Raf-1, ER-alpha, and Bcl-2 in MCF-7 cells by Western blot, only Bcl-2 protein expression was significantly increased in MCF-7 cells transfected with BAG-1 p50 and p46, respectively. The mechanism by which BAG-1 affected the function of Bcl-2 was exploredby using the cycloheximide chase assay. |
1(0,0,0,1) | Details |
| 17118471 | Marin-Vinader L, van Genesen ST, Lubsen NH: mRNA made during heat shock enters the first round of translation. Biochim Biophys Acta. 2006 Nov-Dec;1759(11-12):535-42. Epub 2006 Oct 24. As NMD substrate we used the human psigammaE-crystallin gene, which contains a premature termination codon, and as control, its close relative, the human gammaD-crystallin gene, both placed under control of the Hsp70 promoter. |
1(0,0,0,1) | Details |
| 17172411 | Lee JH, Park JH, Jung Y, Kim JH, Jong HS, Kim TY, Bang YJ: Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells. Mol Cancer Ther. 2006 Dec;5(12):3085-95. Cotreatment with trichostatin A and cycloheximide restored TS mRNA expression, suggesting that TS mRNA is repressed through new protein synthesis. Mechanistically, TS protein was found to interact with heat shock protein (Hsp) complex, and trichostatin A treatment induced chaperonic Hsp90 acetylation and subsequently enhanced Hsp70 binding to TS, which led to the proteasomal degradation of TS protein. |
1(0,0,0,1) | Details |