| Name | p50 |
|---|---|
| Synonyms | ARHGEF 7; PAK3; p85; p50; ARHGEF7; BETA PIX; COOL 1; COOL1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19151744 | Liu HY, Wang ZM, Bai Y, Wang M, Li Y, Wei S, Zhou QH, Chen J: Different BAG-1 isoforms have distinct functions in modulating chemotherapeutic-induced apoptosis in breast cancer cells. Acta Pharmacol Sin. 2009 Feb;30(2):235-41. Epub 2009 Jan 19. Furthermore, the cycloheximide chase assay indicated that the degradation of Bcl-2 protein was extended in the BAG-1 p50 and p46 transfected MCF-7 cells. |
35(0,1,1,5) | Details |
| 18719026 | Buzzelli MD, Nagarajan M, Radtka JF, Shumate ML, Navaratnarajah M, Lang CH, Cooney RN: Nuclear factor-kappaB mediates the inhibitory effects of tumor necrosis factor-alpha on growth hormone-inducible gene expression in liver. Endocrinology. 2008 Dec;149(12):6378-88. Epub 2008 Aug 21. Cycloheximide did not antagonize the inhibitory effects of TNF on GH-inducible IGF-I expression. Cotransfection of CWSV-1 cells with expression vectors for p65 alone or p50 and p65 together inhibited GH-inducible Spi 2.1 and IGF-I promoter activity. |
1(0,0,0,1) | Details |
| 15782119 | Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S: Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. Oncogene. 2005 Jun 2;24(24):3976-86. Previous investigations have demonstrated that both proliferation and survival of H-RS cells require constitutive NF-kappaB activity, which is comprised of the p50 and RelA subunits. In addition, treatment with a protein synthesis inhibitor cycloheximide rapidly downregulated inhibitor of NF-kappaB (IkappaB) kinase activity in H-RS cells. |
1(0,0,0,1) | Details |
| 16637064 | Choi W, Proctor L, Xia Q, Feng Y, Gerner EW, Chiao PJ, Hamilton SR, Zhang W: Inactivation of IkappaB contributes to transcriptional activation of / N (1)-acetyltransferase. Mol Carcinog. 2006 Sep;45(9):685-93. CHX quickly eliminated the IkappaB protein in the cells and increased the levels of the two subunits of NFkappaB, p65 and p50, in the nucleus. |
1(0,0,0,1) | Details |
| 18941459 | Diallo JS, Betton B, Parent N, Peant B, Lessard L, Le Page C, Bertrand R, Mes-Masson AM, Saad F: Enhanced killing of androgen-independent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors. Br J Cancer. 2008 Nov 18;99(10):1613-22. Epub 2008 Oct 21. Although blocking transcription using actinomycin D does not modulate PC3 cell sensitivity to IP6, inhibition of protein translation using cycloheximide has a significant protective effect. |
0(0,0,0,0) | Details |