Protein Information

Name TR1
Synonyms GRIM 12; TR1; TR; KM 102 derived reductase like factor; TRXR 1; TRXR1; TXNR; TXNRD 1…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
17110078 El-Sayed WM, Aboul-Fadl T, Roberts JC, Lamb JG, Franklin MR: Murine hepatoma (Hepa1c1c7) cells: a responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds. Toxicol In Vitro. 2007 Feb;21(1):157-64. Epub 2006 Oct 7.

Induction responses to the selenazolidines were also eliminated (most) or reduced (Txnrd1 by 2-methylSCA) by cycloheximide, with the exception of Ugt1a6.
34(0,1,1,4) Details
16136269 Danforth DN, Zhu Y: Conversion of Fas-resistant to Fas-sensitive MCF-7 breast cancer cells by the synergistic interaction of interferon-gamma and all-trans retinoic acid. Breast Cancer Res Treat. 2005 Nov;94(1):81-91.


FasR-induced cells were resistant to stimulation of apoptosis by anti-FasR antibody, however treatment with cycloheximide rendered these cells sensitive to antibody-induced apoptosis, suggesting endogenous blockade to signaling.
0(0,0,0,0) Details