| Name | PARP |
|---|---|
| Synonyms | COL11A2; PARP; Collagen alpha 2(XI) chain; Collagen alpha 2(XI) chain precursor; Collagen type XI alpha 2; Collagen type XI alpha 2 isoform 1; DFNA13; DFNB53… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17961153 | Sotelo-Silveira J, Crispino M, Puppo A, Sotelo JR, Koenig E: Myelinated axons contain beta-actin mRNA and ZBP-1 in periaxoplasmic ribosomal plaques and depend on cyclic AMP and F-actin integrity for in vitro translation. J Neurochem. 2008 Jan;104(2):545-57. Epub 2007 Oct 24. Periaxoplasmic ribosomal plaques (PARPs) are periodic structural formations containing ribosomes, which are likely cortical sites of translation along myelinated fibers. beta-actin mRNA, and its trans-acting binding factor, zipcode-binding protein-1, were co-distributed within PARP domains of axoplasmic whole-mounts isolated from goldfish Mauthner, rabbit and rat nerve fibers. A metabolically active isolated Mauthner fiber system, which required cAMP to activate translation, was developed in order to probe cycloheximide-sensitivity, and the importance of the actin cytoskeleton. cAMP greatly stimulated protein synthesis in axoplasm after a period of pre-incubation, while being inhibited strongly by cycloheximide, or by cytochalasin D. |
3(0,0,0,3) | Details |
| 17283163 | Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ: Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Cancer Res. 2007 Feb 1;67(3):1262-9. FAS inhibitor-induced ER stress is activated prior to the detection of caspase 3 and PARP cleavage, primary indicators of cell death, whereas orlistat-induced cell death is rescued by coincubation with the global translation inhibitor cycloheximide. |
31(0,1,1,1) | Details |
| 17962448 | Goodkin ML, Epstein S, Asbell PA, Blaho JA: Nuclear translocation of NF-kappaB precedes apoptotic poly (ADP- polymerase cleavage during productive HSV-1 replication in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2007 Nov;48(11):4980-8. However, wt HSV-1-infected cells produced detectable levels of cleaved poly (ADP- (PARP). |
3(0,0,0,3) | Details |
| 20032379 | Eriksson D, Lofroth PO, Johansson L, Riklund K, Stigbrand T: Apoptotic signalling in HeLa Hep2 cells following 5 Gy of -60 gamma radiation. Anticancer Res. 2009 Nov;29(11):4361-6. Cleavage of poly (ADP- polymerase (PARP) was analysed on Western blots. HeLa Hep2 cells were irradiated with or without preincubation with inhibitors of protein synthesis (cycloheximide, CHX) and caspases, followed by TUNEL staining and caspase assay plate evaluation. |
2(0,0,0,2) | Details |
| 16087277 | Zupanska A, Dziembowska M, Ellert-Miklaszewska A, Gaweda-Walerych K, Kaminska B: Cyclosporine a induces growth arrest or programmed cell death of human glioma cells. Neurochem Int. 2005 Nov;47(6):430-41. Moreover, CsA-induced cell death was accompanied by activation of executory caspases followed by PARP cleavage. |
1(0,0,0,1) | Details |
| 16910777 | Dasgupta J, Subbaram S, Connor KM, Rodriguez AM, Tirosh O, Beckman JS, Jourd'Heuil D, Melendez JA: Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2. Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1295-305. The increase in H (2) O (2) was associated with decreased sensitivity to TNF-alpha-mediated apoptosis, as measured by monitoring the loss of mitochondrial membrane potential (MMP), caspase activation, poly-ADP polymerase (PARP) cleavage, and accumulation of hypodiploid DNA content. |
1(0,0,0,1) | Details |
| 15863130 | Hougardy BM, van der Zee AG, van den Heuvel FA, Timmer T, de Vries EG, de Jong S: Sensitivity to Fas-mediated apoptosis in high-risk HPV-positive human cervical cancer cells: relationship with Fas, caspase-8, and Bid. Gynecol Oncol. 2005 May;97(2):353-64. Analysis of the Fas apoptotic pathway showed that anti-Fas treatment induced caspase-8 activation and concomitantly Bid cleavage, caspase-9 and caspase-3 activation, PARP cleavage and apoptosis in HeLa and CaSki. |
1(0,0,0,1) | Details |
| 16526045 | Hareramadas B, Rai U: Cellular mechanism of -induced thymic involution in wall lizard: caspase-dependent action. J Exp Zool A Comp Exp Biol. 2006 May 1;305(5):396-409. In the presence of TEC, a positive reaction for caspase-3, -7 and -9 and enzyme substrate, poly (ADP- polymerase (PARP) in response to E2 suggests the caspase-dependent thymocyte apoptosis in the wall lizard Hemidactylus flaviviridis. |
1(0,0,0,1) | Details |
| 16133866 | Drexler HC, Euler M: Synergistic apoptosis induction by proteasome and histone deacetylase inhibitors is dependent on protein synthesis. Apoptosis. 2005 Aug;10(4):743-58. Apoptosis induction was associated with caspase 8, 3 and 9 activation, Bid processing, destruction of the mitochondrial membrane potential, cleavage of PARP and lamin B and extensive DNA fragmentation. The most striking anti-apoptotic effect though was obtained by the translational inhibitor cycloheximide, which abolished caspase 8 processing, blocked Bid cleavage and maintained the mitochondrial transmembrane potential. |
1(0,0,0,1) | Details |
| 16004999 | Hareramadas B, Rai U: Mechanism of androgen-induced thymic atrophy in the wall lizard, Hemidactylus flaviviridis: an in vitro study. Gen Comp Endocrinol. 2005 Oct;144(1):10-9. DHT-induced thymocyte apoptosis was found to be caspase-dependent since it activated the initiator (caspase-9) and effector caspases (caspases-3 and -7) as well as cleaved the enzyme substrate poly (ADP- polymerase (PARP). |
1(0,0,0,1) | Details |
| 16647178 | Chen TJ, Jeng JY, Lin CW, Wu CY, Chen YC: inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells. Toxicology. 2006 Jun 1;223(1-2):113-26. Epub 2006 Mar 22. Induction of HO-1 protein expression was detected in QUE- but not RUT- or QUI-treated C6 cells, and this was prevented by cycloheximide and actinomycin D. |
0(0,0,0,0) | Details |
| 15639338 | Hofmanova J, Vaculova A, Kozubik A: Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis. Cancer Lett. 2005 Jan 31;218(1):33-41. The higher amount of floating cells, subG0/G1 population and apoptotic cells detected in pre-treated cells was potentiated by cycloheximide. |
0(0,0,0,0) | Details |
| 15876423 | Chow JM, Shen SC, Huan SK, Lin HY, Chen YC: but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol. 2005 Jun 15;69(12):1839-51. Results of Western blotting show that QE but not its glycoside rutin (RUT) and quicitrin-induced HO-1 protein expression in a time- and dose-dependent manner, and HO-1 protein induced by QE was blocked by an addition of cycloheximide or actinomycin D. |
0(0,0,0,0) | Details |