| Name | ATPase |
|---|---|
| Synonyms | ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16121032 | Tattersall AL, Browning JA, Wilkins RJ: Modulation of H+ transport mechanisms by interleukin-1 in isolated bovine articular chondrocytes. Cell Physiol Biochem. 2005;16(1-3):43-50. In keeping with this observation, the protein synthesis inhibitor cycloheximide abolished the stimulatory effect of IL-1 on ATPase-mediated extrusion. |
35(0,1,1,5) | Details |
| 17585910 | Ito S, Ihara T, Tamura H, Tanaka S, Ikeda T, Kajihara H, Dissanayake C, Abdel-Motaal FF, El-Sayed MA: alpha-Tomatine, the major saponin in tomato, induces programmed cell death mediated by reactive species in the fungal pathogen Fusarium oxysporum. FEBS Lett. 2007 Jul 10;581(17):3217-22. Epub 2007 Jun 15. In the present study, mechanisms involved in alpha-tomatine-induced cell death of fungi were examined using a filamentous pathogenic fungus Fusarium oxysporum. alpha-Tomatine-induced cell death of F. oxysporum (TICDF) occurred only under aerobic conditions and was blocked by the mitochondrial F (0) F (1)-ATPase inhibitor oligomycin, the caspase inhibitor D-VAD-fmk, and protein synthesis inhibitor cycloheximide. |
31(0,1,1,1) | Details |
| 16602240 | Karitskaia IA, Aksenov ND, Vinogradova TA, Marakhova II: [Il-2-regulated expression of Na+,K (+)-ATPase in activated human lymphocytes]. Tsitologiia. 2005;47(1):28-37. A translation inhibitor cycloheximide was found to prevent the late increase in alfa1-subunit expression. |
4(0,0,0,4) | Details |
| 19396617 | Carraro-Lacroix LR, Girardi AC, Malnic G: Long-term regulation of vacuolar H (+)-ATPase by angiotensin II in proximal tubule cells. Pflugers Arch. 2009 Sep;458(5):969-79. Epub 2009 Apr 26. |
4(0,0,0,4) | Details |
| 15695513 | Vagin O, Turdikulova S, Yakubov I, Sachs G: Use of the H,K-ATPase beta subunit to identify multiple sorting pathways for plasma membrane delivery in polarized cells. J Biol Chem. 2005 Apr 15;280(15):14741-54. Epub 2005 Feb 4. |
4(0,0,0,4) | Details |
| 16475832 | Shukla S, Rai V, Banerjee D, Prasad R: Characterization of Cdr1p, a major multidrug efflux protein of Candida albicans: purified protein is amenable to intrinsic fluorescence analysis. Biochemistry. 2006 Feb 21;45(7):2425-35. We had earlier characterized Cdr1p by its overexpression as a GFP-tagged fusion protein that elicits oligomycin-sensitive ATPase activity and is linked to drug extrusion. |
3(0,0,0,3) | Details |
| 18842589 | Sauna ZE, Bohn SS, Rutledge R, Dougherty MP, Cronin S, May L, Xia D, Ambudkar SV, Golin J: Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport. J Biol Chem. 2008 Dec 12;283(50):35010-22. Epub 2008 Oct 8. We describe a novel mutation (S558Y) in transmembrane helix 2 of Pdr5 identified in a screen for suppressors that eliminated Pdr5-mediated cycloheximide hyper-resistance. Wild-type and mutant Pdr5s show ATPase activity with comparable K (m)((ATP)) values. |
2(0,0,0,2) | Details |
| 17703090 | Kundu S, Roy S, De J, Biswas A, Pramanik M, Ray AK: Maintenance of homeostasis for thyroid hormone in the adult rat brain: possible involvement of a nuclear-mediated phenomenon. Neuroendocrinology. 2007;86(2):94-103. Epub 2007 Aug 16. During our investigation to understand the mechanism further, we injected the protein synthesis blockers actinomycin D and cycloheximide along with propylthiouracil to adult male rats during the days of onset (day 2) and termination (day 20) of the homeostatic mechanism. We evaluated synaptosomal T (3) level and neuronal Na (+)-K (+)-ATPase and acetylcholinesterase activities along with deiodinase II activity and cyclic level in the cerebral cortex. |
2(0,0,0,2) | Details |
| 18295760 | Peres-Sampaio CE, de Almeida-Amaral EE, Giarola NL, Meyer-Fernandes JR: Leishmania amazonensis: effects of heat shock on ecto-ATPase activity. Exp Parasitol. 2008 May;119(1):135-43. Epub 2008 Jan 24. The Mg-dependent ATPase activity of cells grown at 22 and 28 degrees C was 41.0+/-5.2 nmol Pi/h x 10 (7) cells and 184.2+/-21.0 nmol Pi/h x 10 (7) cells, respectively. Interestingly, cycloheximide, an inhibitor of protein synthesis, suppressed the heat-shock effect on ecto-ATPase activity of cells grown at 22 degrees C were exposed at 37 degrees C for 2h. |
2(0,0,0,2) | Details |
| 19716839 | Charlson AT, Zeliadt NA, Wattenberg EV: Extracellular signal regulated kinase 5 mediates signals triggered by the novel tumor promoter palytoxin. Toxicol Appl Pharmacol. 2009 Dec 1;241(2):143-53. Epub 2009 Aug 28. Cycloheximide, okadaic acid, and orthovanadate did not mimic the effect of palytoxin on ERK5. The major cell surface receptor for palytoxin is the Na+,K+-ATPase. |
2(0,0,0,2) | Details |
| 19851033 | El-Beialy W, Galal N, Deyama Y, Yoshimura Y, Suzuki K, Tei K, Totsuka Y: Effects of on PMCA 2 and 4 in human fibroblast-like synovial cells and mouse macrophage-like cells. Endocr J. 2010;57(1):93-7. Epub 2009 Oct 23. We investigated the possible roles of on plasma membrane Ca (2+)-ATPase (PMCA) in human fibroblast-like synovial cells (HFLS) and mouse macrophage-like cells (RAW 264.7). However, treatments for 1 hour in the presence or absence of cycloheximide demonstrated non-significant effects. |
2(0,0,0,2) | Details |
| 18344484 | Zuo J, Vergara S, Kohno S, Holliday LS: Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase. J Exp Biol. 2008 Apr;211(Pt 7):1102-8. Screening null yeast or null yeast transformed with wild-type or mutant B subunits with sub-lethal doses of various drugs revealed that yeast containing the mutant B subunits were more sensitive to cycloheximide and wortmannin than those transformed with wild-type B subunits. |
2(0,0,0,2) | Details |
| 19401877 | Hatou S, Yamada M, Mochizuki H, Shiraishi A, Joko T, Nishida T: The effects of dexamethasone on the Na,K-ATPase activity and pump function of corneal endothelial cells. Curr Eye Res. 2009 May;34(5):347-54. PURPOSE: The Na (+)- and K (+)-dependent ATPase (Na,K-ATPase) expressed in the basolateral membrane of corneal endothelial cells plays an important role in the pump function of the corneal endothelium. These effects of dexamethasone were blocked by cycloheximide, a protein synthesis inhibitor. |
2(0,0,0,2) | Details |
| 17550899 | Bish RA, Myers MP: Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain. J Biol Chem. 2007 Aug 10;282(32):23184-93. Epub 2007 Jun 5. The WRNIP1 ubiquitin-binding function, along with its previously established ATPase activity, suggests that WRNIP1 plays a role in the metabolism of ubiquitinated proteins. Supporting this model, deletion of MGS1, the yeast homolog of WRNIP1, slows the rate of ubiquitin turnover, rendering yeast resistant to cycloheximide. |
1(0,0,0,1) | Details |
| 15701621 | Ma TY, Boivin MA, Ye D, Pedram A, Said HM: Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol. 2005 Mar;288(3):G422-30. Moreover, inhibitors of MLCK, Mg (2+)-myosin ATPase, and metabolic energy prevented the TNF-alpha increase in Caco-2 TJ permeability, suggesting that the increase in MLCK activity was required for the TNF-alpha-induced opening of the Caco-2 TJ barrier. The TNF-alpha increase in MLCK protein expression paralleled the increase in Caco-2 TJ permeability, and the inhibition of the TNF-alpha-induced MLCK expression (by cycloheximide) prevented the increase in Caco-2 TJ permeability, suggesting that MLCK expression may be required for the increase in Caco-2 TJ permeability. |
1(0,0,0,1) | Details |
| 20149622 | Perez A, Centeno VA, Tolosa de Talamoni NG: Molecular mechanisms involved in the enhancement of mitochondrial malate dehydrogenase activity by in chick intestine. J Nutr Biochem. 2010 Feb 8. Consequently, ATP production would be increased, facilitating the Ca (2+) exit from the enterocytes via the Ca (2+)-ATPase and Na (+)/Ca (2+) exchanger, which participate in the intestinal Ca (2+) absorption. In some experiments, animals were injected with cycloheximide. |
1(0,0,0,1) | Details |
| 16885392 | Castillo C, Ceballos G, Rodriguez D, Villanueva C, Medina R, Lopez J, Mendez E, Castillo EF: Effects of on contractility associated with intracellular release in rat aorta. Am J Physiol Cell Physiol. 2006 Dec;291(6):C1388-94. Epub 2006 Aug 2. Neither cycloheximide (1 microM; inhibitor of protein synthesis) nor tamoxifen (1 microM; blocker of estrogenic receptors) modified the effects of In addition, (100 microM) inhibited the contractile responses to cyclopiazonic acid (1 microM; selective Ca (2+)-ATPase inhibitor) associated with capacitative Ca (2+) influx through non-L-type Ca (2+) channels. |
1(0,0,0,1) | Details |
| 20138054 | Vandock KP, Drummond CA, Smith SL, Fioravanti CF: Midgut and fatbody mitochondrial transhydrogenase activities during larval-pupal development of the tobacco hornworm, Manduca sexta. J Insect Physiol. 2010 Feb 9. The -forming activity occurs as a nonenergy- or energy-linked activity with energy for the latter derived from either electron transport-dependent or utilization, or ATP hydrolysis by Mg (++)-dependent ATPase. Moreover, that the increases in all transhydrogenase activities resulted from de novo enzyme synthesis were indicated by the cycloheximide-dependent reductions in these activities. |
1(0,0,0,1) | Details |
| 19180575 | Ni L, Saeki M, Xu L, Nakahara H, Saijo M, Tanaka K, Kamisaki Y: RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage. J Cell Biochem. 2009 Apr 1;106(5):920-8. We have previously reported that Monad, a novel WD40 repeat protein, potentiates apoptosis induced by tumor necrosis factor-alpha and cycloheximide. Here we report that Reptin, a highly conserved AAA + ATPase that is part of various chromatin-remodeling complexes, is also involved in the association of RPAP3 by immunoprecipitation and confocal microscopic analysis. |
1(0,0,0,1) | Details |
| 18977303 | Pozza A, Perez-Victoria JM, Di Pietro A: Overexpression of homogeneous and active ABCG2 in insect cells. Protein Expr Purif. 2009 Feb;63(2):75-83. Epub 2008 Oct 21. Evidences suggest that this is due to the accumulation of an immature ABCG2 species, since: (i) the upper species, with higher apparent molecular weight, was favored by treatments reducing the rate of protein synthesis; (ii) the lower species was accumulated in presence of an endoplasmic reticulum stress inducer, and could be converted into the upper species during electrophoresis with 9 M urea; (iii) each species was differently solubilized by detergents: the upper species was partially solubilized by non-ionic and zwitterionic detergents, whereas the lower one required stronger surfactants; (iv) membrane ATPase activity from infected insect cells was essentially associated to the upper species. |
1(0,0,0,1) | Details |
| 19706404 | Zhang J, Rubio V, Lieberman MW, Shi ZZ: OLA1, an Obg-like ATPase, suppresses antioxidant response via nontranscriptional mechanisms. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15356-61. Epub 2009 Aug 24. Moreover, when de novo protein synthesis was blocked by cycloheximide in OLA1-knockdown cells, they continued to demonstrate increased resistance to both tBH and diamide. |
1(0,0,0,1) | Details |
| 18436532 | Kohlmann S, Schafer A, Wolf DH: Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation. J Biol Chem. 2008 Jun 13;283(24):16374-83. Epub 2008 Apr 24. Hul5 activity promotes the interaction of this truncated CTL*myc with the AAA-ATPase Cdc48, which is known to pull proteins out of the ER membrane. |
1(0,0,0,1) | Details |
| 16052351 | Akimova OA, Pchejetski D, Hamet P, Orlov SN: Modest intracellular acidification suppresses death signaling in ouabain-treated cells. Pflugers Arch. 2006 Jan;451(4):569-78. Epub 2005 Jul 29. Recently, we observed that ouabain kills epithelial and endothelial cells via its interaction with Na (+), K (+) -ATPase, but independently of inhibition of Na (+), K (+) -ATPase-mediated ion fluxes and inversion of the [Na (+)](i)/[K (+)](i) ratio. The death of ouabain-treated cells was independent of inhibition of RNA and protein synthesis with actinomycin D and cycloheximide. |
1(0,0,0,1) | Details |
| 16495213 | Carraro-Lacroix LR, Ramirez MA, Zorn TM, Reboucas NA, Malnic G: Increased NHE1 expression is associated with serum deprivation-induced differentiation in immortalized rat proximal tubule cells. Am J Physiol Renal Physiol. 2006 Jul;291(1):F129-39. Epub 2006 Feb 21. Using pHi measurements with the fluorescent probe BCECF, we demonstrated that the IRPTC express both Na+/H+ exchanger and H+-ATPase, but only NHE1 is modulated by serum deprivation. The altered activity of NHE1 was consistent with an increase of both transcription and translation of the antiporter, as the utilization of actinomycin D and cycloheximide significantly inhibited the upregulation of NHE1 induced by serum withdrawal. |
1(0,0,0,1) | Details |
| 18055878 | Murray IA, Perdew GH: stimulates the induction of human insulin-like growth factor binding protein-1 through aryl hydrocarbon receptor activation. J Pharmacol Exp Ther. 2008 Mar;324(3):1102-10. Epub 2007 Nov 30. 5-Methoxy-2-{(4-methoxy-3,5-dimethyl-pyridin-2-yl) methylsulfinyl}-3H-benzo a benzoimidazole-derived gastric H (+)/K (+)-ATPase proton pump inhibitor (PPI) extensively prescribed for the treatment of gastroesophageal acid reflux disease, can stimulate the expression of CYP1A1 via activation of the human aryl hydrocarbon receptor (hAhR) in an apparent nonligand-binding manner. Cotreatment with cycloheximide further suggests a direct transcriptional role for hAhR at the hIGFBP-1 promoter. |
1(0,0,0,1) | Details |
| 16548285 | Castillo C, Castillo EF, Lopez J, Lopez RM: inhibits the contractile responses to associated with the release of intracellular in rat aorta]. Gac Med Mex. 2006 Jan-Feb;142(1):1-8. These changes were not affected by cycloheximide (10 (-5) M; a protein synthesis inhibitor of), flutamide (10 (-5) M; an androgenic receptor antagonist), or by adding aminoglutethimide (10 (-5) M; an aromatase inhibitor). On the other hand, inhibited the contractile responses to cyclopiazonic acid (10 (-6) M; a selective Ca2+ -ATPase inhibitor) or ryanodine (10 (-5 M; an activator of sarcoplasmic reticulum Ca2+ -release channels) associated with capacitative Ca2+ influx through non-L-type Ca2+ channels. |
1(0,0,0,1) | Details |
| 19164805 | Rutledge AC, Qiu W, Zhang R, Kohen-Avramoglu R, Nemat-Gorgani N, Adeli K: Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminus. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):579-85. Epub 2009 Jan 22. Here we demonstrate key roles of BiP, an ER luminal chaperone, and p97, a cytosolic ATPase anchored to the ER membrane, in the targeting of apoB for proteasomal degradation. |
1(0,0,0,1) | Details |
| 17301147 | Murray KE, Nibert ML: inhibits mammalian orthoreovirus growth by reversibly blocking the synthesis of double-stranded RNA. J Virol. 2007 May;81(9):4572-84. Epub 2007 Feb 14. In addition, the coordinated use of GuHCl and cycloheximide allowed us to demonstrate that MRV dsRNA synthesis can occur in the absence of ongoing protein synthesis, although to only a limited extent. |
0(0,0,0,0) | Details |
| 20351147 | Tormakangas L, Markkula E, Lounatmaa K, Puolakkainen M: Chlamydia pneumoniae infection in polarized epithelial cell lines. Infect Immun. 2010 Mar 29. The effect of cycloheximide on the growth of C. pneumoniae in the polarized cells was negligible. |
0(0,0,0,0) | Details |