| Name | adenylyl cyclase |
|---|---|
| Synonyms | ADCY 7; ATP pyrophosphate lyase; Adenylyl cyclase; ADCY7; ADCY7 protein; ATP pyrophosphate lyase 7; Adenylate cyclase 7; Adenylate cyclase type 7… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17064391 | Sosroseno W, Musa M, Ravichandran M, Fikri Ibrahim M, Bird PS, Seymour GJ: The role of cyclic-AMP on arginase activity by a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2006 Dec;21(6):347-52. The effects of SQ22536 (an adenylyl cyclase inhibitor), ODQ (a guanylyl cyclase inhibitor), dibutyryl cAMP (a cAMP analog), 8-bromo cyclic (a analog), forskolin (an adenylyl cylase activator), and cycloheximide (a protein synthesis inhibitor) on arginase activity in A. actinomycetemcomitans LPS-stimulated RAW264.7 cells were also determined. |
31(0,1,1,1) | Details |
| 16120652 | Osawa Y, Lee HT, Hirshman CA, Xu D, Emala CW: Lipopolysaccharide-induced sensitization of adenylyl cyclase activity in murine macrophages. Am J Physiol Cell Physiol. 2006 Jan;290(1):C143-51. Epub 2005 Aug 24. LPS caused a significant dose (5-10,000 ng/ml)- and time (1-8 h)-dependent increase in forskolin-stimulated AC activity that was abrogated by pretreatment with SN50 (an NF-kappaB inhibitor), actinomycin D, or cycloheximide, indicating that the effect is mediated via NF-kappaB-dependent transcription and new protein synthesis. |
2(0,0,0,2) | Details |
| 15677378 | Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA: Downregulation of the type 2 receptor after -induced internalization: involvement of a lysosomal degradation pathway. Am J Physiol Cell Physiol. 2005 Jun;288(6):C1390-401. Epub 2005 Jan 26. Cycloheximide reduced the intensity of this patch, showing that newly synthesized V2R-GFP contributed significantly to its appearance. V2R-GFP showed characteristics similar to those of wild-type V2R, including high affinity for VP and adenylyl cyclase stimulation. |
1(0,0,0,1) | Details |
| 15912208 | Lehmann TP, Biernacka-Lukanty JM, Saraco N, Langlois D, Li JY, Trzeciak WH: Temporal pattern of the induction of SF-1 gene expression by the signal transduction pathway involving 3',5'-cyclic adenosine monophosphate. Acta Biochim Pol. 2005;52(2):485-91. Epub 2005 May 15. We evaluated the temporal pattern of the effects of corticotropin (ACTH) and the adenylyl cyclase activator forskolin on the level of SF-1 mRNA, and compared the time course of induction of SF-1 with that of CYP11A1. The effect of forskolin was augmented by cycloheximide, suggesting that an inhibitory protein, whose synthesis was inhibited by cycloheximide, could be involved in negative regulation of SF-1 expression. |
1(0,0,0,1) | Details |
| 17438304 | Sonalker PA, Jackson EK: via beta-adrenoceptors, regulates bumetanide-sensitive cotransporter type 1 expression in thick ascending limb cells. Hypertension. 2007 Jun;49(6):1351-7. Epub 2007 Apr 16. Treatment with either alone or in the presence of actinomycin D or cycloheximide, had no effect on cotransporter mRNA levels. To further elucidate the mechanism, thick ascending limb cells were treated with in the presence of phentolamine (alpha-adrenoceptor blocker), (beta-adrenoceptor blocker), SQ22536 (adenylyl cyclase inhibitor), PD098059 (mitogen-activated protein kinase pathway inhibitor), H-89 (protein kinase A inhibitor), or staurosporine (protein kinase C inhibitor). |
1(0,0,0,1) | Details |
| 16353668 | Lehmann TP, Biernacka-Lukanty JM, Trzeciak WH, Li JY: Steroidogenic factor 1 gene transcription is inhibited by transforming growth factor beta. Endocr Res. 2005;31(2):71-9. A Northern blot analysis with the use of a radiolabeled cDNA probe, and immunodetection with antibodies directed against SF-1, demonstrated that the Sf-1 transcript and the SF-1 protein levels were lowered by TGF-beta in Y-1 adrenocortical cells, both in untreated and adenylyl cyclase activator, forskolin-treated cells. Inhibition of Sf-1 expression by TGF-beta was abolished by cycloheximide, suggesting that the growth factor inhibitory effect requires ongoing protein synthesis. |
1(0,0,0,1) | Details |
| 16644694 | Koehler JA, Drucker DJ: Activation of glucagon-like peptide-1 receptor signaling does not modify the growth or apoptosis of human pancreatic cancer cells. Diabetes. 2006 May;55(5):1369-79. Although cholera toxin (an activator of Galphas) and forskolin (an activator of adenylyl cyclase) increased levels of intracellular cAMP in all cell lines, the GLP-1R agonist exendin-4 (Ex-4) increased cAMP only in CFPAC-1 cells. Ex-4 did not modulate the proliferation of these cell lines in vitro and did not inhibit apoptosis after exposure of cells to cytotoxic agents such as cycloheximide, indomethacin, LY294002, or cyclopamine. |
1(0,0,0,1) | Details |
| 17218408 | Sasseville M, Cote N, Vigneault C, Guillemette C, Richard FJ: 3'5'-cyclic adenosine monophosphate-dependent up-regulation of phosphodiesterase type 3A in porcine cumulus cells. Endocrinology. 2007 Apr;148(4):1858-67. Epub 2007 Jan 11. The PMSG-dependent increase in Pde3 activity and Pde3a mRNA were mimicked by the adenylyl cyclase activator forskolin or The cilostamide-sensitive increase in PDE activity was inhibited by a protein synthesis inhibitor, cycloheximide. |
1(0,0,0,1) | Details |
| 16493643 | Han DW, Patel N, Douglas Watson R: Regulation of protein synthesis in Y-organs of the blue crab (Callinectes sapidus): involvement of cyclic AMP. J Exp Zool A Comp Exp Biol. 2006 Apr 1;305(4):328-34. Addition of both forskolin (an adenylyl cyclase activator) and 3-isobutyl-1-methylxanthine (a phosphodiesterase inhibitor) likewise suppressed incorporation of [(35) S] into Y-organ proteins. Cycloheximide (a protein synthesis inhibitor) suppressed incorporation of [(35) S] into Y-organ proteins and secretion of ecdysteroids. |
1(0,0,0,1) | Details |
| 17029796 | Madhyastha HK, Radha KS, Sugiki M, Omura S, Maruyama M: C-phycocyanin transcriptionally regulates uPA mRNA through cAMP mediated PKA pathway in human fibroblast WI-38 cells. Biochim Biophys Acta. 2006 Nov;1760(11):1624-30. Epub 2006 Aug 24. We also provide evidence that c-pc stimulates uPA gene through cAMP dependent pathway as adenylyl cyclase (AC) inhibitor, dideoxyadenosine (DDA) significantly inhibited the uPA mRNA expression and co-treatment with adenylyl cyclase analogue, dBcAMP recovered the effect of c-pc on gene activity. Co-treatment of c-pc with 200 microg/ml cycloheximide (CHX), translation inhibitor, resulted in over accumulation of uPA mRNA. |
1(0,0,0,1) | Details |