Protein Information

Name pyruvate dehydrogenase (protein family or complex)
Synonyms Pyruvate dehydrogenase; Pyruvate dehydrogenases

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
10535932 Regnstrom K, Sauge-Merle S, Chen K, Burgess BK: In Azotobacter vinelandii, the E1 subunit of the pyruvate dehydrogenase complex binds fpr promoter region DNA and ferredoxin I. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12389-93.

Here, we report the identification of the A. vinelandii protein that binds specifically to the paraquat activatable fpr promoter region as the E1 subunit of the pyruvate dehydrogenase complex (PDHE1), a central enzyme in aerobic respiration.
32(0,1,1,2) Details
17573932 Park BS, Kwon YM, Pyla R, Boyle JA, Jung YS: E1 component of pyruvate dehydrogenase complex does not regulate the expression of NADPH-ferredoxin reductase in Azotobacter vinelandii. FEMS Microbiol Lett. 2007 Aug;273(2):244-52. Epub 2007 Jun 16.

In Azotobacter vinelandii, the E1 component of pyruvate dehydrogenase complex (PDHE1) is proposed to be a key regulatory protein in an oxidative stress management system that responds to superoxide.
This mutant exhibited wild-type exponential growth and a normal response to oxidative stress induced by paraquat.
1(0,0,0,1) Details