| Name | acylpeptide hydrolase |
|---|---|
| Synonyms | AARE; DNF15S2; ACPH; APEH; APH; Acyl peptide hydrolase; Acylamino acid releasing enzyme; Acylaminoacyl peptidase… |
| Name | dichlorvos |
|---|---|
| CAS | 2,2-dichloroethenyl dimethyl phosphate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19379766 | Olmos C, Sandoval R, Rozas C, Navarro S, Wyneken U, Zeise M, Morales B, Pancetti F: Effect of short-term exposure to dichlorvos on synaptic plasticity of rat hippocampal slices: involvement of acylpeptide hydrolase and alpha (7) nicotinic receptors. Toxicol Appl Pharmacol. 2009 Jul 1;238(1):37-46. Epub 2009 Apr 18. A few years ago it was reported that dichlorvos inhibits the enzyme acylpeptide hydrolase at lower doses than those necessary to inhibit acetylcholinesterase to the same extent. |
275(3,4,4,5) | Details |
| 10953051 | Richards PG, Johnson MK, Ray DE: Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs. Mol Pharmacol. 2000 Sep;58(3):577-83. Acylpeptide hydrolase was found to be potently inhibited by the organophosphorus compounds chlorpyrifosmethyl oxon, dichlorvos, and diisopropylfluorophosphate (20-min IC (50) values of 18.3 +/- 2.0, 118.7 +/- 9.7, and 22.5 +/- 1.2 nM, respectively). |
199(2,3,3,9) | Details |
| 18049927 | Pancetti F, Olmos C, Dagnino-Subiabre A, Rozas C, Morales B: Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. J Toxicol Environ Health B Crit Rev. 2007 Dec;10(8):623-30. This enzyme is more sensitive than AChE to some organophosphates (OP), including dichlorvos, which is the parent compound for metrifonate, a therapeutic agent used in the treatment of cognitive impairment associated to Alzheimer's disease. |
4(0,0,0,4) | Details |
| 15888665 | Quistad GB, Klintenberg R, Casida JE: Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants. Toxicol Sci. 2005 Aug;86(2):291-9. Epub 2005 May 11. The most potent in vitro inhibitors for human erythrocyte and mouse brain APH are DFP (IC (50) 11-17 nM), chlorpyrifos oxon (IC (50) 21-71 nM), dichlorvos (IC (50) 230-560 nM), naled (IC (50) 370-870 nM), and their analogs with modified alkyl substituents. (3) H-diisopropyl fluorophosphate is a potent inhibitor of mouse blood and brain APH in vivo (ED (50) 0.09-0.2 mg/kg and 0.02-0.03 mg/l for ip and vapor exposure, respectively). |
2(0,0,0,2) | Details |