Protein Information

Name complex is
Synonyms 39kD; CI 39kD; Complex I; Complex I 39kD; NADH dehydrogenase (ubiquinone) Fe S protein 2 like; NADH ubiquinone oxidoreductase 39 kDa subunit mitochondrial; NADH ubiquinone oxidoreductase 39 kDa subunit; NDUFA 9…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
17429807 Karmaker S, Saha TK, Sakurai H: Investigation of a Cu (II)-poly (gamma-glutamic acid) complex in aqueous solution and its insulin-mimetic activity. Macromol Biosci. 2007 Apr 10;7(4):456-66.


Formation of the Cu (II)-gamma-PGA complex is confirmed by the observation of the blue shift of the absorption band in the visible region, anisotropic line shapes in the ESR spectrum at room temperature, and a computer simulation of the visible absorption spectrum of the complex.
2(0,0,0,2) Details
9545555 Adhikari S, Joshi R, Gopinathan C: Bilirubin as an anti precipitant against copper mediated denaturation of bovine serum albumin: formation of copper-bilirubin complex. Biochim Biophys Acta. 1998 Mar 12;1380(1):109-14.

The Cu-BR complex is stable at a pH ranging from 3.5 to 13.2, and also can scavenge radicals like CCl3OO., eaq- and OH..
Addition of excess copper sulfate to the solution of this complex causes a greenish black precipitate which can be re dissolved in HCl but insoluble in 99% ethanol.
2(0,0,0,2) Details
9409001 Toida T, Shima M, Azumaya S, Maruyama T, Toyoda H, Imanari T, Linhardt RJ: Detection of glycosaminoglycans as a copper (II) complex in high-performance liquid chromatography. J Chromatogr A. 1997 Nov 7;787(1-2):266-70.

Detection was achieved at 240 nm based on the formation of copper (II) complex in copper sulfate solution at low pH.
Detection of the copper (II)-heparin complex is sensitive, permitting the analysis of as little as 10 (-7) g.
1(0,0,0,1) Details
3094197 Wallace KB: Nonenzymatic oxygen activation and stimulation of lipid peroxidation by doxorubicin-copper. Toxicol Appl Pharmacol. 1986 Oct;86(1):69-79.


The data demonstrate that despite the implication of hydrogen peroxide and hydroxyl radicals in doxorubicin-copper stimulated lipid peroxidation, the immediate product of dioxygen reduction by the complex is superoxide-free radicals.
1(0,0,0,1) Details
12420162 Buurman ET, Jiang W, McCoy M, Averett DR, Thompson CM, Wobbe CR: Validation of Cdc68p as a novel antifungal target. . Arch Microbiol. 2002 Dec;178(6):428-36. Epub 2002 Sep 3.


Furthermore, CDC68 was proven to be present in Neurospora crassa and Aspergillus nidulans, thus suggesting that the CP complex is widespread among fungi and could serve as a broad range antifungal target.
1(0,0,0,1) Details
1194179 Karawya MS, Diab AM: Spectrophotometric assay of salsolidine hydrochloride. J Assoc Off Anal Chem. 1975 Nov;58(6):1169-70.

The proposed method is based on the reaction of salsolidine HCl with carbon disulfide and ammoniacal copper sulfate.
The resulting salsolidine-copper-dithiocarbamate complex is extracted with benzene and measured spectrophotometrically at 448 nm.
1(0,0,0,1) Details
406928 Rohde W, Cordell B, Webster R, Levinson W: Inhibition of amino acyl tRNA synthetase activity by copper complexes of two metal binding ligands. Biochim Biophys Acta. 1977 Jul 15;477(2):102-11.

The 1 : 1 ligand-metal complex is significantly more active than the 2 : 1 complex.
The free ligand alone and copper sulfate alone have little, if any, effect.
1(0,0,0,1) Details
8900940 Toida T, Linhardt RJ: Detection of glycosaminoglycans as a copper (II) complex in capillary electrophoresis. Electrophoresis. 1996 Feb;17(2):341-6.

Detection was achieved at 240 nm based on the formation of a copper (II) complex in copper sulfate solution at low pH.
Detection of the copper (II)-heparin complex is extremely sensitive, permitting the analysis of as little as 10 (-9) g.
1(0,0,0,1) Details
11099965 Piro OE, Piatti RC, Bolzan AE, Salvarezza RC, Arvia AJ: X-ray diffraction study of copper (I) thiourea complexes formed in sulfate-containing acid solutions. Acta Crystallogr B. 2000 Dec;56 (Pt 6):993-7.

The ratio between Cu (I) and thiourea (tu) in these complexes depends on the amount of thiourea and copper sulfate in the solution.
The Cu-thiourea complex is arranged as a Cu (I) tetranuclear ion, [Cu (4)(tu)(12)](4+), sited on a crystallographic inversion center.
1(0,0,0,1) Details