| Name | complex is |
|---|---|
| Synonyms | 39kD; CI 39kD; Complex I; Complex I 39kD; NADH dehydrogenase (ubiquinone) Fe S protein 2 like; NADH ubiquinone oxidoreductase 39 kDa subunit mitochondrial; NADH ubiquinone oxidoreductase 39 kDa subunit; NDUFA 9… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18039652 | Cocheme HM, Murphy MP: Complex I is the major site of mitochondrial production by paraquat. J Biol Chem. 2008 Jan 25;283(4):1786-98. Epub 2007 Nov 26. |
162(2,2,2,2) | Details |
| 16141438 | Richardson JR, Quan Y, Sherer TB, Greenamyre JT, Miller GW: Paraquat neurotoxicity is distinct from that of MPTP and rotenone. Toxicol Sci. 2005 Nov;88(1):193-201. Epub 2005 Sep 1. Based on structural similarity to MPP+, it has been proposed that paraquat exerts selective dopaminergic toxicity through transport by the DAT and subsequent inhibition of mitochondrial complex I. |
113(1,2,2,3) | Details |
| 17127363 | Gomez C, Bandez MJ, Navarro A: Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front Biosci. 2007 Jan 1;12:1079-93. The determination of -cytochrome c reductase, -cytochrome c reductase and cytochrome oxidase activities in rat brain submitochondrial showed again the selective inhibition of Complex I by rotenone and pyridaben, whereas paraquat produced a non-selective inhibition affecting all the respiratory chain complexes. |
33(0,1,1,3) | Details |
| 18812510 | Choi WS, Kruse SE, Palmiter RD, Xia Z: Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15136-41. Epub 2008 Sep 23. These data suggest that dopaminergic neuron death induced by treatment with rotenone, MPP (+), or paraquat is independent of complex I inhibition. |
33(0,1,1,3) | Details |
| 19125564 | Zhu K, Li S, Wang F, Huang F: Anion-controlled ion-pair recognition of paraquat by a bis (m-phenylene)-32-crown-10 derivative heteroditopic host. J Org Chem. 2009 Feb 6;74(3):1322-8. The host-guest complex is a pseudorotaxane in the solid state when the two counterions of paraquat are trifluoroacetate anions while it is a taco complex when the two counterions are hexafluorophosphate or anions. |
31(0,1,1,1) | Details |
| 17880941 | Rojo AI, Cavada C, de Sagarra MR, Cuadrado A: Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats. Exp Neurol. 2007 Nov;208(1):120-6. Epub 2007 Aug 22. A new model based on daily inoculation of neurotoxins in the nasal cavity of C57BL/6 mice for 30 days was used to evaluate risk of three complex I inhibitors, 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP), rotenone and paraquat. |
31(0,1,1,1) | Details |
| 15371739 | Isaev NK, Stelmashook EV, Ruscher K, Andreeva NA, Zorov DB: reduces rotenone-induced cell death in cerebellar granule neurons. Neuroreport. 2004 Oct 5;15(14):2227-31. Chemical hypoxia (term defining the simulation by using respiratory inhibitors) chosen as in vitro ischemic model, was induced in primary cultures of rat cerebellar granule neurons by inhibitors of mitochondrial electron transport such as rotenone or paraquat (complex I), 3-nitropropionic acid (3-NPA, complex II), antimycin A (complex III), or azide (complex IV). |
31(0,1,1,1) | Details |
| 19348901 | Cocheme HM, Murphy MP: Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria. Methods Enzymol. 2009;456:395-417. Paraquat causes extensive mitochondrial oxidative damage, and in mammalian systems, complex I of the respiratory chain has been identified as the major site of production by paraquat. |
31(0,1,1,1) | Details |
| 11835632 | Vicente JA, Peixoto F, Lopes ML, Madeira VM: Differential sensitivities of plant and animal mitochondria to the herbicide paraquat. J Biochem Mol Toxicol. 2001;15(6):322-30. However, with potato tuber mitochondria, the Delta (psi) promoted by complex-I-dependent respiration is insensitive to this effect, indicating a protection against paraquat radical afforded by complex I redox activity, which was just the reverse of to the findings for rat liver mitochondria. |
6(0,0,1,1) | Details |
| 18253895 | Yang W, Tiffany-Castiglioni E: Paraquat-induced apoptosis in human neuroblastoma SH-SY5Y cells: involvement of p53 and mitochondria. J Toxicol Environ Health A. 2008;71(4):289-99. By 24 h, paraquat decreased mitochondrial complex I activity and mitochondrial transmembrane potential and induced the release of cytochrome c from mitochondria. |
6(0,0,1,1) | Details |
| 19767442 | Drechsel DA, Patel M: Differential contribution of the mitochondrial respiratory chain complexes to reactive species production by redox cycling agents implicated in parkinsonism. Toxicol Sci. 2009 Dec;112(2):427-34. Epub 2009 Sep 18. Bipyridyl herbicides, such as paraquat (PQ), diquat (DQ), and benzyl viologen (BV), are redox cycling agents known to exert cellular damage through the production of reactive oxygen species (ROS). Interestingly, at micromolar (< or = 300 microM) concentrations, PQ-induced H2O2 production was unaffected by complex I inhibition via rotenone, whereas DQ-induced H2O2 production was equally attenuated by inhibition of complex I or III. |
2(0,0,0,2) | Details |
| 20346072 | Yang W, Hekimi S: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell. 2010 Mar 19. We have identified nuo-6 (qm200), a mutation in a conserved subunit of mitochondrial complex I (NUDFB4). We have compared the phenotypes of nuo-6 (qm200) to those of nuo-6 (RNAi) and found them to be distinct in crucial ways, including patterns of growth and fertility, behavioral rates, consumption, ATP levels, autophagy, and resistance to paraquat, as well as expression of superoxide dismutases, mitochondrial heat shock proteins, and other gene expression markers. |
2(0,0,0,2) | Details |
| 17320357 | Park JS, Li YF, Bai Y: Yeast NDI1 improves oxidative phosphorylation capacity and increases protection against oxidative stress and cell death in cells carrying a Leber's hereditary optic neuropathy mutation. Biochim Biophys Acta. 2007 May;1772(5):533-42. Epub 2007 Jan 26. G11778A in the subunit ND4 gene of NADH dehydrogenase complex is the most common primary mutation found in Leber's hereditary optic neuropathy (LHON) patients. Finally, transformants were also shown to be desensitized to induction to apoptosis and also exhibit greater resistance to paraquat-induced cell death. |
2(0,0,0,2) | Details |
| 20089602 | Van Osch FS, Piliguian M, Hill KA: Spontaneous mutation frequency is elevated in skin of harlequin (hq)/Big Blue (R) mice. Mutagenesis. 2010 Jan 20. Acute PQ exposure had only subtle effects in WT mice and reduced mitochondrial complex I activity and elevated antioxidant enzyme activity in hq disease mice may lead to PQ resistance. The frequency and pattern of cII mutations in skin from adult hq disease and wild-type (WT) mice 15 days after a single intraperitoneal (i.p.) injection of paraquat (PQ; 10 mg/kg) or vehicle control (VC) were determined to assess spontaneous mutagenesis and sensitivity to an exogenous ROS-inducing mutagen. |
1(0,0,0,1) | Details |
| 16979221 | Leiser SF, Salmon AB, Miller RA: Correlated resistance to deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice. Mech Ageing Dev. 2006 Nov;127(11):821-9. Epub 2006 Sep 18. Snell dwarf fibroblasts are here reported to differ from control cell lines in two other respects: they are relatively resistant to the metabolic inhibition induced by low concentrations, and also resistant to the effects of the mitochondrial poison rotenone, a blocker of Complex I of the electron transport chain. Furthermore, analysis of cell lines derived from a group of genetically heterogeneous mice established that cell lines resistant to peroxide-induced cytotoxicity were also relatively resistant to death induced by paraquat, cadmium, and ultraviolet light. |
1(0,0,0,1) | Details |
| 19072795 | Gasa TB, Spruell JM, Dichtel WR, Sorensen TJ, Philp D, Stoddart JF, Kuzmic P: Complexation between methyl viologen (paraquat) bis (hexafluorophosphate) and dibenzo [24] crown-8 revisited. Chemistry. 2009;15(1):106-16. The monocationic 1:1 host-guest complex is the most abundant species under typical (0.5-20 mM) experimental conditions. |
1(0,0,0,1) | Details |
| 16239214 | Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues CM, Alfonso A, Steer C, Liu L, Przedborski S, Wolozin B: Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem. 2005 Dec 30;280(52):42655-68. Epub 2005 Oct 19. C. elegans lines with these genetic changes were more vulnerable than nontransgenic nematodes to mitochondrial complex I inhibitors, including rotenone, fenperoximate, pyridaben, or stigmatellin. In contrast, the genetic manipulations did not increase sensitivity to paraquat, azide, divalent metal ions (Fe (II) or Cu (II)), or etoposide compared with the nontransgenic nematodes. |
1(0,0,0,1) | Details |
| 15451049 | Bretaud S, Lee S, Guo S: Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicol Teratol. 2004 Nov-Dec;26(6):857-64. One valuable type of animal model for PD is established by treating animals with PD-inducing neurotoxins, including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, and paraquat. These neurotoxins are thought to inhibit mitochondrial complex I activity leading to oxidative stress, impaired energy metabolism, proteasomal dysfunction, and, eventually, neuronal loss. |
1(0,0,0,1) | Details |
| 19744517 | Hosamani R, Muralidhara: Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogaster. Neurotoxicology. 2009 Nov;30(6):977-85. Epub 2009 Sep 8. Environmental toxins like rotenone, a specific inhibitor of complex I is employed to increase oxidative stress mediated neuropathology and sporadic Parkinson's disease. Interestingly, BM also conferred significant resistance (43-54% protection) in a paraquat oxidative stress bioassay. |
1(0,0,0,1) | Details |
| 11843590 | Jeppesen JO, Becher J, Stoddart JF: Poised on the brink between a bistable complex and a compound. Org Lett. 2002 Feb 21;4(4):557-60. [reaction: see text] An enmeshed supramolecular complex, based on a semi-dumbbell-shaped component containing an asymmetrically substituted tetrathiafulvalene site and a 1,5-dioxynaphthalene site for encirclement by a cyclobis (paraquat-p-phenylene) ring component and with a "speed bump" in the form of an thiomethyl group situated between the two recognition sites, has been self-assembled. This complex is a mixture in solution of two slowly interconverting [2] pseudorotaxanes, one of which is on the verge of being a [2] rotaxane at room temperature. |
1(0,0,0,1) | Details |
| 19747824 | Copeland JM, Cho J, Lo T Jr, Hur JH, Bahadorani S, Arabyan T, Rabie J, Soh J, Walker DW: Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Curr Biol. 2009 Oct 13;19(19):1591-8. Epub 2009 Sep 10. In addition, extended longevity is not consistently correlated with reduced fertility or increased resistance to the free-radical generator paraquat. Targeted RNAi of two complex I genes in adult tissues or in neurons alone is sufficient to extend life span. |
1(0,0,0,1) | Details |
| 14605795 | Yousef N, Pistorius EK, Michel KP: Comparative analysis of idiA and isiA transcription under iron starvation and oxidative stress in Synechococcus elongatus PCC 7942 wild-type and selected mutants. Arch Microbiol. 2003 Dec;180(6):471-83. Epub 2003 Nov 7. Since the NDH I complex is involved in cyclic electron transport activity around PS I in cyanobacteria and both adaptation to iron starvation and adaptation to oxidative stress lead to an enhanced cyclic electron transport activity around PS I, this potential [Fe-S]-protein might participate in the overall adaptational response to iron starvation and/or oxidative stress in Synechococcus. |
1(0,0,0,1) | Details |
| 19232048 | Tarasenko VI, Garnik EY, Shmakov VN, Konstantinov YM: Induction of Arabidopsis gdh2 gene expression during changes in redox state of the mitochondrial respiratory chain. Biochemistry. 2009 Jan;74(1):47-53. Lack of activation of gene expression after treatment of a cell suspension with peroxide and the prooxidant paraquat and results of experiments with antioxidants suggest that gdh2 gene expression is not associated with increased content of reactive species generated during inhibition of the electron transport chain. |
0(0,0,0,0) | Details |
| 17018646 | Ramachandiran S, Hansen JM, Jones DP, Richardson JR, Miller GW: Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicol Sci. 2007 Jan;95(1):163-71. Epub 2006 Oct 3. |
0(0,0,0,0) | Details |