| Name | extracellular signal regulated kinase 1 |
|---|---|
| Synonyms | ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16687388 | Niso-Santano M, Moran JM, Garcia-Rubio L, Gomez-Martin A, Gonzalez-Polo RA, Soler G, Fuentes JM: Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death. Toxicol Sci. 2006 Aug;92(2):507-15. Epub 2006 May 9. Furthermore, early paraquat-mediated increases in ERK1/2 activation were sensitive to the mitogen-activated protein kinase kinase 1 (MEK1) inhibitor PD 98059 (2'-amino-3'-methoxyflavone), whereas JNK1/2 responses were blocked by the JNK1/2 inhibitor SP 600125 (anthra [1-9-cd] pyrazol-6 (2H)-one). |
205(1,5,5,5) | Details |
| 17662968 | Miller RL, Sun GY, Sun AY: Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent oxidase. Brain Res. 2007 Sep 5;1167:129-39. Epub 2007 Jul 10. The inhibitors for protein kinase C delta (PKCdelta) or extracellular signal-regulated kinases (ERK1/2) could partially attenuate paraquat-induced ROS production and cell death. |
37(0,1,2,2) | Details |
| 19786089 | Sun LY, Steinbaugh MJ, Masternak MM, Bartke A, Miller RA: Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes. Free Radic Biol Med. 2009 Dec 15;47(12):1753-61. Epub 2009 Sep 26. This study shows that phosphorylation of the stress-activated protein kinases ERK1/2 induced by peroxide, cadmium, or paraquat is attenuated in cells from these mice. |
33(0,1,1,3) | Details |
| 19386805 | Xia XJ, Wang YJ, Zhou YH, Tao Y, Mao WH, Shi K, Asami T, Chen Z, Yu JQ: Reactive species are involved in brassinosteroid-induced stress tolerance in cucumber. Plant Physiol. 2009 Jun;150(2):801-14. Epub 2009 Apr 22. BR treatment induced expression of both regulatory genes, such as RBOH, MAPK1, and MAPK3, and genes involved in defense and antioxidant responses. |
1(0,0,0,1) | Details |
| 16919916 | Mitra S, Abraham E: Participation of in neutrophil activation and cytokine production. Biochim Biophys Acta. 2006 Aug;1762(8):732-41. Epub 2006 Jul 8. To examine the role of in neutrophil activation, we exposed resting neutrophils and neutrophils stimulated with LPS to paraquat, an agent that specifically increases intracellular concentrations. |
0(0,0,0,0) | Details |