Protein Information

Name peptide methionine sulfoxide reductases
Synonyms Cytosolic methionine S sulfoxide reductase (Methionine sulfoxide reductase A3); MSRA; Methionine sulfoxide reductase A1; Methionine sulfoxide reductase A2; PMSR; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase; Protein methionine S oxide reductase…

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
15516509 Romero HM, Berlett BS, Jensen PJ, Pell EJ, Tien M: Investigations into the role of the plastidial peptide methionine sulfoxide reductase in response to oxidative stress in Arabidopsis. Plant Physiol. 2004 Nov;136(3):3784-94. Epub 2004 Oct 29.

4(0,0,0,4) Details
11867705 Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T: High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2748-53. Epub 2002 Feb 26.

The MSRA transgenic animals are more resistant to paraquat-induced oxidative stress, and the onset of senescence-induced decline in the general activity level and reproductive capacity is delayed markedly.
10(0,0,1,5) Details
15843963 In O, Berberich T, Romdhane S, Feierabend J: Changes in gene expression during dehardening of cold-hardened winter rye (Secale cereale L.) leaves and potential role of a peptide methionine sulfoxide reductase in cold-acclimation. Planta. 2005 Apr;220(6):941-50. Epub 2004 Nov 10.

However, the ScPMSR mRNA was also induced by prolonged exposure (48 h) to high light at 22 degrees C, or by treatment with 2 muM paraquat.
4(0,0,0,4) Details
11157941 Merkamm M, Guyonvarch A: Cloning of the sodA gene from Corynebacterium melassecola and role of superoxide dismutase in cellular viability. J Bacteriol. 2001 Feb;183(4):1284-95.

A second open reading frame, coding for a putative 217-amino-acid protein with high homology to peptide methionine sulfoxide reductases from various origins, has been identified immediately upstream of sodA in the opposite transcription orientation.
The growth rate of the SOD-deficient integrant was only slightly affected in BHI rich medium as well as in BMCG chemically defined medium, but was strongly affected by the presence of the redox-cycling agent paraquat.
1(0,0,0,1) Details
19487311 Salmon AB, Perez VI, Bokov A, Jernigan A, Kim G, Zhao H, Levine RL, Richardson A: Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span. FASEB J. 2009 Oct;23(10):3601-8. Epub 2009 Jun 1.

Methionine sulfoxide reductase A (MsrA) repairs oxidized methionine residues within proteins and may also function as a general antioxidant.
We show here that MsrA (-/-) mice are more susceptible to oxidative stress induced by paraquat.
1(0,0,0,1) Details