Protein Information

Name Lipoxygenase (protein family or complex)
Synonyms arachidonate lipoxygenase; arachidonate lipoxygenases; lipoxygenase; lipoxygenases

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
9261142 Oorni K, Pentikainen MO, Annila A, Kovanen PT: Oxidation of low density lipoprotein particles decreases their ability to bind to human aortic proteoglycans. J Biol Chem. 1997 Aug 22;272(34):21303-11.

We therefore treated LDL with various substances: copper sulfate, 2,2'-azobis (2-amidinopropane) hydrochloride (AAPH), soybean lipoxygenase, and mouse peritoneal macrophages, and determined the extent to which the oxidatively modified LDL bound to human aortic proteoglycans in an affinity column.
32(0,1,1,2) Details
11352990 Chang MY, Potter-Perigo S, Wight TN, Chait A: Oxidized LDL bind to nonproteoglycan components of smooth muscle extracellular matrices. J Lipid Res. 2001 May;42(5):824-33.

LDL was modified with 2,2-azo-bis (2-amidinopropane)-2HCl, hypochlorite, soybean lipoxygenase, and phospholipase or copper sulfate.
31(0,1,1,1) Details
1546066 Derian CK, Lewis DF: Activation of 15-lipoxygenase by low density lipoprotein in vascular endothelial cells. Prostaglandins Leukot Essent Fatty Acids. 1992 Jan;45(1):49-57.

7(0,0,0,7) Details
11590223 Edelstein C, Nakajima K, Pfaffinger D, Scanu AM: Oxidative events cause degradation of apoB-100 but not of apo [a] and facilitate enzymatic cleavage of both proteins. J Lipid Res. 2001 Oct;42(10):1664-70.


In this study, we examined the in vitro susceptibility of LDL and Lp [a], obtained from the same donor, to oxidation by either Cu (2)+ or the combined Crotalus adamanteus phospholipase A2 and soybean lipoxygenase system, monitoring the course of the reaction by the generation of conjugated dienes and fatty acids.
1(0,0,0,1) Details
8400082 Keane WF, O'Donnell MP, Kasiske BL, Kim Y: Oxidative modification of low-density lipoproteins by mesangial cells. J Am Soc Nephrol. 1993 Aug;4(2):187-94.


Native LDL subjected to chemical oxidation by copper sulfate also inhibited mesangial cell proliferation.
0(0,0,0,0) Details