Protein Information

Name PPAR gamma
Synonyms HUMPPARG; PAX8/PPARG fusion gene; NR1C3; PPAR gamma; PPAR gamma2; PPARG; PPARG 1; PPARG 2…

Compound Information

Name abscisic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
20015036 Bassaganya-Riera J, Skoneczka J, Kingston DG, Krishnan A, Misyak SA, Guri AJ, Pereira A, Carter AB, Minorsky P, Tumarkin R, Hontecillas R: Mechanisms of action and medicinal applications of abscisic Acid. . Curr Med Chem. 2010;17(5):467-78.

A unique finding in mammalian systems, however, is that the peroxisome proliferator-activated receptor, PPAR gamma, is upregulated by ABA in both in vitro and in vivo studies.
3(0,0,0,3) Details
20236740 Guri AJ, Hontecillas R, Bassaganya-Riera J: Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration. Clin Nutr. 2010 Mar 15.

In vitro, ABA increased CTLA-4 expression through a PPAR gamma-dependent mechanism.
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20207056 Guri AJ, Hontecillas R, Bassaganya-Riera J: Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: Possible action of the cAMP/PKA/PPAR gamma axis. Clin Nutr. 2010 Mar 4.
115(1,2,2,5) Details
17618105 Guri AJ, Hontecillas R, Ferrer G, Casagran O, Wankhade U, Noble AM, Eizirik DL, Ortis F, Cnop M, Liu D, Si H, Bassaganya-Riera J: Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue. J Nutr Biochem. 2008 Apr;19(4):216-28. Epub 2007 Jul 6.

Abscisic acid (ABA) is a natural phytohormone and peroxisome proliferator-activated receptor gamma (PPARgamma) agonist that significantly improves insulin sensitivity in db/db mice.
40(0,1,2,5) Details
17000034 Guri AJ, Hontecillas R, Si H, Liu D, Bassaganya-Riera J: Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets. Clin Nutr. 2007 Feb;26(1):107-16. Epub 2006 Sep 26.

METHODS: We first examined whether ABA, similar to TZDs, activates PPARgamma in vitro.
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